A5100365831- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Diabetes Treatment and Management
- Intraocular Surgery and Lenses
- Parkinson's Disease Mechanisms and Treatments
- Medical Research and Treatments
- Ocular Surface and Contact Lens
- Nuclear Receptors and Signaling
- Glaucoma and retinal disorders
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ophthalmology and Visual Impairment Studies
- Plant biochemistry and biosynthesis
- Microbial Natural Products and Biosynthesis
- Dietary Effects on Health
- Acute Lymphoblastic Leukemia research
- Spine and Intervertebral Disc Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Salivary Gland Disorders and Functions
- Acute Ischemic Stroke Management
- Neuroscience and Neuropharmacology Research
- Retinopathy of Prematurity Studies
- Cellular transport and secretion
- Ferroptosis and cancer prognosis
- Retinoids in leukemia and cellular processes
Quzhou College of Technology
2025
Jiangxi University of Traditional Chinese Medicine
2025
Central South University
2025
Hunan Cancer Hospital
2025
Université Paris-Saclay
2023-2024
Shandong First Medical University
2020-2024
Qingdao University
2021-2024
Shandong Eye Hospital
2020-2024
Shanxi Medical University
2011-2024
Second Hospital of Shanxi Medical University
2011-2024
ABSTRACT Rationale Gentiana urnula Harry Sm is a frequently utilized traditional Chinese medicine (TCM) with applications in the treatment of range ailments including jaundice, gastrointestinal ulcers, and influenza. Despite its widespread uses, there lack comprehensive researches on chemical composition. Methods This study integrated SIRIUS, quantitative structure‐retention relationship (QSRR), liquid chromatography high‐resolution mass spectrometry (LC‐HRMS) to identify compounds Sm....
Epidemics and pandemics of cholera, a severe diarrheal disease, have occurred since the early 19th century waves epidemic disease continue today. Cholera epidemics are caused by individual, genetically monomorphic lineages Vibrio cholerae: ongoing seventh pandemic, which has spread globally 1961, is associated with lineage L2 biotype El Tor. Previous genomic studies epidemiology pandemic identified three successive sub-lineages within L2, designated 1 to 3, from Bay Bengal on multiple...
The incretins glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are growth factors. GLP-1 mimetics on the market as treatments for type 2 diabetes. Both GIP have shown neuroprotective properties in previous studies. In addition, mimetic exendin-4 has protective effects a clinical trial Parkinson's disease (PD) patients. Novel GLP-1/GIP dual-agonist peptides been developed to treat Here, we report of novel dual agonist (DA-JC1)...
Human pluripotent stem cells (hPSCs) hold great promise for the treatment of various human diseases. However, their therapeutic benefits and mechanisms treating corneal endothelial dysfunction remain undefined. Here, we developed a regimen consisting combination hPSC-derived precursors (CEPs) with nicotinamide (NAM) effective dysfunction. In rabbit nonhuman primate models, intracameral injection CEPs NAM achieved long-term recovery clarity thickness, similar outcome cultured (CECs). The...
Vinblastine has been used clinically as one of the most potent therapeutics for treatment several types cancer. However, traditional plant extraction method suffers from unreliable supply, low abundance, and extremely high cost. Here, we use synthetic biology approach to engineer Saccharomyces cerevisiae de novo biosynthesis vindoline catharanthine, which can be coupled chemically or biologically vinblastine. On basis a platform strain with sufficient supply precursors cofactors...
β-Elemene, an active ingredient found in medicinal plants like turmeric and zedoary, is a sesquiterpene compound with antitumor activity against various cancers. However, its current mode of production through plant extraction suffers from low efficiency limited natural resources. Recently, there has been increased interest establishing microbial cell factories to produce germacrene A, which can be converted β-elemene by one-step reaction vitro. In this study, we constructed engineered...
Purposes Domestic and international research has found that patients with advanced cancer prioritize increasing their quality of life above extending lives simple or intensive treatments. The current study investigates the pathways to improve patients’ sense well-being from family, social, individual levels, is say, it mediating roles comprehending social support as well psychological resilience in relationship between family subjective well-being, also provides references for future...
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonists have been shown to be neuroprotective in previous studies animal models of Alzheimer's or Parkinson's disease. Recently, novel dual-GLP-1/GIP that activate both receptors (DA) were developed treat diabetes. We tested the protective effects a potent DA against middle cerebral artery occlusion injury rats compared it with GLP-1 analog, Val(8)-GLP-1(glu-PAL). Animals evaluated for neurologic...
Rheumatoid arthritis (RA) is a commonly occurring autoimmune disease. Its defining pathological characteristic the excessive proliferation of fibroblast‑like synoviocytes (FLS), which similar to tumor cells and results in range clinical problems. As used antipyretic, analgesic anti‑inflammatory drug, aspirin first‑line treatment for RA. However, its mechanism action has not been well explained. The goal investigate biological effects on primary RA‑FLS underlying mechanisms. In this...
Abstract Purpose This study evaluated the clinical safety and efficacy of tanfanercept (HBM9036) ophthalmic solution as a novel treatment for dry eye disease (DED) in controlled adverse environment (CAE) conducted China. Methods In single-center, double-masked, randomized, placebo-controlled study, 100 patients received 0.25% tanfanercept, or placebo, twice daily eight weeks. A mobile international CAE ® DE Model was used patient selection with standardized challenge endpoint. Primary...
Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors worldwide, and its prognosis still not optimistic. Oxaliplatin a type platinum chemotherapeutic agent, but treatment effects on OSCC molecular mechanisms have been fully elucidated. Parthanatos, unique form death, plays an important role in variety physiological pathological processes. This study aims to investigate whether oxaliplatin inhibits by inducing parthanatos. Our results showed that inhibited...
(−)-Ambroxide is a key ingredient of the fauna natural perfume ambergris, which currently mainly supplied by semi-synthetic route using plant-extracted sclareol as raw material. Biosynthesis (−)-ambradiol direct precursor ambroxide holds promise for addressing energy and environmental concerns in this process. Due to lack producer ambradiol from glucose unrevealed metabolic pathway ambradiol, we divided whole into two modules built an artificial microbial consortium engineered...
To investigate changes in regional homogeneity (ReHo) and the functional connectivity of entorhinal cortex (EC) vascular mild cognitive impairment (VaMCI) to evaluate relationships between such neuropsychological measures VaMCI individuals. In all, 31 patients with 32 normal controls (NCs) underwent rs-fMRI. Differences whole-brain ReHo seed-based bilateral EC (EC-FC) were determined. Pearson's correlation was used regions significant group differences different measures. had significantly...