A5086775802- Advanced DC-DC Converters
- Endoplasmic Reticulum Stress and Disease
- Advanced Power Amplifier Design
- Multilevel Inverters and Converters
- Autophagy in Disease and Therapy
- Analog and Mixed-Signal Circuit Design
- Nerve injury and regeneration
- Silicon Carbide Semiconductor Technologies
- Barrier Structure and Function Studies
- Radio Frequency Integrated Circuit Design
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Sensor and Energy Harvesting Materials
- Wireless Power Transfer Systems
- Psoriasis: Treatment and Pathogenesis
- Pancreatic function and diabetes
- Asthma and respiratory diseases
- Wound Healing and Treatments
- Advanced Battery Technologies Research
- Electromagnetic Compatibility and Noise Suppression
- Manufacturing Process and Optimization
- Epigenetics and DNA Methylation
- Dermatologic Treatments and Research
- CCD and CMOS Imaging Sensors
- Dielectric materials and actuators
- Dermatology and Skin Diseases
Harbin Institute of Technology
2022-2025
Central Hospital of Zibo
2025
China Shenhua Energy (China)
2017-2025
Wuhan University of Technology
2024
Beijing Institute of Technology
2019-2023
Weifang Medical University
2022
Wenzhou Medical University
2013-2021
Institute of Acoustics
2021
Novartis (China)
2015-2021
Tongji University
2021
The blood–brain barrier (BBB) is composed of capillary endothelial cells, pericytes, and perivascular astrocytes, which regulate central nervous system homeostasis. Sonic hedgehog (SHH) released from astrocytes plays an important role in the maintenance BBB integrity. disruption microglial activation are common pathological features various neurologic diseases such as multiple sclerosis, Parkinson's disease, amyotrophic lateral Alzheimer's disease. Interleukin-1β (IL-1β), a major...
IL-17A is a key driver of human autoimmune diseases, particularly psoriasis.We sought to determine the role in psoriasis pathogenesis and identify robust measurable biomarker IL-17A-driven pathology.We studied 8 healthy subjects patients with before after administration secukinumab, fully anti-IL-17A mAb, used combination classical techniques novel skin microperfusion assay evaluate expression 170 proteins blood, nonlesional skin, lesional skin. For validation, we also tested stored sera...
Hypertrophic scars (HTS) and keloids are challenging problems. Their pathogenesis results from an overproduction of fibroblasts excessive deposition collagen. Studies suggest a possible anti-scarring effect basic fibroblast growth factor (bFGF) during wound healing, but the precise mechanisms bFGF still unclear. In view this, we investigated therapeutic effects on HTS animal model as well human scar (HSF) model. We show that promoted healing reduced area flattened non-pathological in rat...
Endoplasmic reticulum (ER) stress-induced apoptosis plays a major role in various diseases, including spinal cord injury (SCI). Nerve growth factor (NGF) show neuroprotective effect and improve the recovery of SCI, but relations ER NGF therapeutic SCI still unclear. Young adult female Sprague-Dawley rats's vertebral column was exposed laminectomy done at T9 vertebrae moderate contusion injuries were performed using vascular clip. stock solution diluted with 0.9% NaCl administered...
Lymphangioleiomyomatosis is a rare, progressive cystic lung disorder characterised by dysregulated activation of mammalian target rapamycin (mTOR) signalling. This was phase IIa, multicentre, open-label study the mTOR inhibitor everolimus (2.5 mg·day −1 escalated to 10 ) in 24 women with lymphangioleiomyomatosis. Primary endpoints were safety, pharmacokinetics and serum vascular endothelial growth factor-D (VEGF-D) levels; secondary measures function. Following 26 weeks treatment, forced...
Extensive research focused on finding effective strategies to prevent or improve recovery from myocardial ischaemia/reperfusion (I/R) injury. Basic fibroblast growth factor (bFGF) has been shown have therapeutic potential in some heart disorders, including ischaemic In this study, we demonstrate that bFGF administration can inhibit the endoplasmic reticulum (ER) stress and mitochondrial dysfunction induced a mouse model of I/R vitro, exerts protective effect by inhibiting ER response...
// Zhouguang Wang 1 , Yan Huang Yi Cheng Tan 1,2 Fenzan Wu Jiamin Hongxue Shi Hongyu Zhang Xichong Yu Hongchang Gao Li Lin Jun Cai 2 Jinsan Xiaokun Lu and Jian Xiao Chinese-American Research Institute for Diabetic Complications, School of Pharmaceutical Science, Key Laboratory Biotechnology Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China Department Pediatrics, Children's Hospital Institute, the University Louisville, Kentucky, USA Correspondence to: Xiao, email: Cai,...
Fibroblasts play a pivotal role in the process of cutaneous wound repair, whereas their migratory ability under diabetic conditions is markedly reduced.In this study, we investigated effect basic fibroblast growth factor (bFGF) on human dermal migration high-glucose environment.bFGF significantly increased by increasing percentage fibroblasts with high polarity index and reorganizing F-actin.A significant increase intracellular reactive oxygen species (ROS) was observed following bFGF...
Interleukin-34 (IL-34) is a newly discovered cytokine as an additional ligand for colony stimulating factor-1 receptor (CSF1R), and its functions are expected to overlap with factor-1/macrophage-colony factor. We have previously shown that the IL-34 primarily produced by neurons in central nervous system (CNS) induces proliferation neuroprotective properties of microglia which express CSF1R. However, CNS still elucidative. Here we show capillary endothelial cells also protected blood–brain...
A family of Class EF resonant inverters with constant ac voltage output and load-independent characteristics are proposed in this paper. Moreover, the design principle topologies their concluded. The low or current stress across switch can be achieved by second-order network. Further, common-ground E/F inverter its procedure introduced. Constant zero switching for a wide load range. To validate theoretical analysis, 1-MHz experimental prototype is built peak efficiency 93.4%.
Abstract Thermoplastic conductive composites are significant materials in modern electronic technologies due to their universal fabrication conditions, phenomenal electrical conductivity, and remarkable mechanical properties. However, the heavy phase separation occurs during thermo‐processing between inorganic fillers polymer matrixes. Conventional thermoplastic exhibit low undesirable properties, which significantly restrict applications. This work successfully arrives at solution for...
Abstract Running in hole (RIH) strings with different bottom assembly separately for perforation, stimulation and production is necessary casing well low permeability carbonate reservoir. Given the time-consuming potential formation damage caused by multi trip RIH, integrated completion technology urgently needed. The stability of packer key consideration implementation technology. In this paper, an string was proposed, corresponding three-dimensional solid model established based on real...
Abstract Purpose To estimate the maximum tolerated dose (MTD) and/or identify recommended Phase II (RP2D) for combined INC280 and buparlisib in patients with recurrent glioblastoma homozygous phosphatase tensin homolog (PTEN) deletion, mutation or protein loss. Methods This multicenter, open-label, Ib/II study included adult mesenchymal-epithelial transcription factor (c-Met) amplification. In Ib, received as capsules tablets combination buparlisib. II, only. Response was assessed centrally...
Abstract Conductive fillers‐embedded plastic polymer hybrid composites are crucial electronic materials in modern technologies owing to their tunable conductive properties, low density, and corrosion resistance. However, the application of traditional rigid inorganic is constrained by subpar electrical conductivity mechanical properties. Consequently, liquid metals (LMs) including gallium gallium‐based alloys, have recently emerged as preferred flexible fillers over fillers. This work...