A5032901555- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- Autophagy in Disease and Therapy
- RNA and protein synthesis mechanisms
- Microtubule and mitosis dynamics
- Acute Myeloid Leukemia Research
- Cancer, Hypoxia, and Metabolism
- Plant Molecular Biology Research
- Glycosylation and Glycoproteins Research
- Genomics and Phylogenetic Studies
- Renal and related cancers
- Peptidase Inhibition and Analysis
- Folate and B Vitamins Research
- Plant Parasitism and Resistance
- Plant Reproductive Biology
- Galectins and Cancer Biology
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
Peking University
2016-2025
Peking University First Hospital
2025
South China Agricultural University
2022-2024
First Affiliated Hospital of Fujian Medical University
2023
Fujian Medical University
2023
Huazhong University of Science and Technology
2023
Shaanxi Normal University
2020-2022
Gansu University of Traditional Chinese Medicine
2021-2022
Soochow University
2020
82th Hospital of Pla
2014-2015
Abstract Background Cancer stem cell (CSC)-related chemoresistance leads to poor outcome of the patients with colorectal cancer (CRC). In this study, we identified chemoresistance-relevant molecules and decipher involved mechanisms provide potential therapeutic target for CRC. We focused on Sec62, a novel significantly increased expression in chemoresistant CRC tissues, further investigated its role progression Methods Through analyzing differentially-expressed genes between chemosensitive...
Hepatocellular carcinoma (HCC) is a highly malignant tumor, and chronic infection with hepatitis B virus one of its major risk factors. To identify the proteins involved in HCC carcinogenesis, we used two-dimensional fluorescence DIGE to study differentially expressed tumor adjacent nontumor tissue samples. Samples from 12 virus-associated patients were analyzed. A total 61 spots significantly up-regulated (ratio ≥ 2, p ≤ 0.01) samples, whereas 158 down-regulated −2, 0.01). Seventy-one gene...
Article5 February 2016Open Access Source Data NAT10 regulates p53 activation through acetylating at K120 and ubiquitinating Mdm2 Xiaofeng Liu Key Laboratory of Carcinogenesis Translational Research (Ministry Education), Peking University Health Science Center, Beijing, China Department Cell Biology, School Basic Medical Sciences, Search for more papers by this author Yuqin Tan Chunfeng Zhang Genetics, Ying Oncology, Cancer Hospital & Institute, Liangliang Pengwei Ren Hongkui Deng Jianyuan...
Anabolism and catabolism are tightly regulated according to the cellular energy supply. Upon stress, ribosomal RNA (rRNA) biogenesis is inhibited, autophagy induced. However, mechanism linking rRNA unclear. Here, we demonstrate that nucleolar protein NAT10 plays a role in transition between autophagy. Under normal conditions, acetylated activate inhibit induction. Mechanistic studies binds acetylates regulator Che-1 at K228 suppress Che-1-mediated transcriptional activation of downstream...
Amino acids metabolism, especially aspartate is often altered in human cancers including hepatocellular carcinoma (HCC) and this metabolic remodeling required for supporting cancer cell malignant activities. Argininosuccinate synthase 1 (ASS1), as a crucial rate-limiting enzyme participates repressing tumor progression. However, the roles of long noncoding RNAs (lncRNAs) metabolism underlying mechanisms remain unclear. Here, we screen LINC01234 an metabolism-related lncRNA HCC. Clinically,...
Tumor cells display augmented capability to maintain endoplasmic reticulum (ER) homeostasis and hijack ER stress pathway for malignant phenotypes under microenvironmental stimuli. Metabolic reprogramming is a well-known hallmark tumor provide specific adaptive traits the alterations. However, it's unknown how orchestrate metabolic progression in response stress. Herein, we aimed explore pivotal roles of SEC63-mediated remodeling hepatocellular carcinoma (HCC) cell metastasis after stress.The...
N-acetyltransferase 10 (NAT10) is a histone acetyltransferase which involved in wide range of cellular processes. Recent evidences indicate that NAT10 the development human cancers. Previous study showed acetylates tumor suppressor p53 and regulates activation. As Tp53 gene frequently mutated hepatocellular carcinoma (HCC) associates with occurrence HCC, relationship between HCC was investigated this study. Immunohistochemistry (IHC) western blot analysis were performed to evaluate...
Abstract Background Hepatocellular carcinoma (HCC) is usually diagnosed at an advanced stage due to rapid progression. Glycolysis supports anabolic growth and metastasis promote HCC However, the molecular mechanisms linking glycolysis in are not completely defined. Methods The expression of PPP1R26 human tissues was evaluated by immunohistochemistry, clinical significance progression prognosis patients were analyzed. PPP1R26-binding proteins determined mass spectrometry analysis. function...
Macroautophagy/autophagy, a major catabolic pathway in eukaryotes, participates plant sexual reproduction including the processes of male gametogenesis and self-incompatibility response. Rapid pollen tube growth is another essential reproductive process that metabolically highly demanding to drive vigorous cell for delivery gametes fertilization angiosperms. Whether how autophagy operates maintain homeostasis tubes remains unknown. Here, we provide evidence elevated growing critically...
Abstract Chemotherapeutic efficacy is seriously impeded by chemoresistance in more than half of hepatocellular carcinoma (HCC) patients. However, the mechanisms involved chemotherapy-induced upregulation chemoresistant genes are not fully understood. Here, this study unravels a novel mechanism controlling nuclear acetyl-CoA production to activate transcription HCC. NAT10 upregulated HCC tissues and its correlated with poor prognosis also cells. Targeting increases cytotoxicity chemotherapy...
Transcription of ribosome RNA precursor (pre-rRNA) and pre-rRNA processing are coordinated by a subset U three proteins (UTPs) known as transcriptional UTPs (t-UTPs), which participate in transcription addition to participation 18 S rRNA processing. However, the mechanism t-UTPs function remains undetermined. In present study, we identified hALP, histone acetyl-transferase novel t-UTP. We first showed that hALP is nucleolar, associated with U3 snoRNA required for Moreover, depletion resulted...
Acute myeloid leukemia (AML) is the second most common form of in children. Aberrant DNA methylation patterns are a characteristic feature various tumors, including AML. Metallothionein III (MT3) tumor suppresser reported to show promoter hypermethylated cancers. However, expression and molecular function MT3 pediatric AML unclear. Eleven human cell lines 41 samples 20 NBM/ITP (Norma bone marrow/Idiopathic thrombocytopenic purpura) control were analyzed. Transcription levels evaluated by...
Background: Human N-acetyltransferase 10 (NAT10) plays pivotal roles in cellular biological processes, such as senescence, autophagy and cytokinesis. The expression of NAT10 is dysregulated colorectal cancer (CRC) associated with the prognosis patients. However, it remains unclear how regulated CRC. Methods: microRNA(miRNA) regulating was predicted by bioinformatics analysis further validated real-time quantitative PCR(RT-qPCR),Western blot dual luciferase reporter assays. miRNA CRC tissues...
To assess the predictive capability of CT radiomics features for early recurrence (ER) pancreatic ductal adenocarcinoma (PDAC). Postoperative PDAC patients were retrospectively selected, all whom had undergone preoperative imaging and surgery. Both with resectable or borderline-resectable cancer met eligibility criteria in this study. However, owing to differences treatment strategies such, research mainly focused on cancer. All subject follow-up assessments a minimum 9 months. A total 250...
Pediatric acute myeloid leukemia (AML) comprises up to 20% of all childhood leukemia. Recent research shows that aberrant DNA methylation patterning may play a role in leukemogenesis. The epigenetic silencing the EBF3 locus is very frequent glioblastoma. However, expression profiles and molecular function pediatric AML still unclear.Twelve human cell lines, 105 samples 30 normal bone marrow/idiopathic thrombocytopenic purpura (NBM/ITP) control were analyzed. Transcriptional level was...
Neuroblastoma (NB) is the most common extra-cranial solid tumor in childhood with overall 5 years' survival less than 40%.Polo-like kinase 1 (PLK1) a serine/threonine-protein expressed during mitosis and over multiple cancers, including neuroblastoma.We found that higher PLK1 expression related to poor outcome of NB patients.BI2536, small molecule inhibitor against PLK1, significantly reduced cell viability panel lines, IC50 100 nM.PLK1 inhibition by BI 2536 treatment induced cycle arrest at...