A5100382155- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Advanced Breast Cancer Therapies
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Spinal Cord Injury Research
- Neuroblastoma Research and Treatments
- Immune Response and Inflammation
- Virus-based gene therapy research
- Parasitic infections in humans and animals
- Acute Myeloid Leukemia Research
- Cancer, Hypoxia, and Metabolism
- Transcranial Magnetic Stimulation Studies
- Parasitic Infections and Diagnostics
- RNA Research and Splicing
- Chronic Lymphocytic Leukemia Research
- Reconstructive Surgery and Microvascular Techniques
- Ubiquitin and proteasome pathways
- Herpesvirus Infections and Treatments
- Mitochondrial Function and Pathology
- Vestibular and auditory disorders
- Neurological Disease Mechanisms and Treatments
- Immune Cell Function and Interaction
- Hearing, Cochlea, Tinnitus, Genetics
Soochow University
2017-2025
Kunming University of Science and Technology
2022-2024
Pacific Northwest National Laboratory
2024
Affiliated Hospital of Qingdao University
2022-2024
First People's Hospital of Yunnan Province
2022-2024
First Affiliated Hospital of GuangXi Medical University
2022-2024
Guangxi Medical University
2022-2024
Second Hospital of Shandong University
2024
Faculty of Public Health
2023
Anhui Medical University
2022-2023
Bone formation and homeostasis are greatly dependent on the osteogenic differentiation of human bone marrow stem cells (BMSCs). Therefore, revealing mechanisms underlying BMSCs will provide new candidate therapeutic targets for osteoporosis.
Aortic dissection (AD) presents a medical challenge for clinicians. Here, to determine the role of novel small non-coding piRNA-823 (piR-823) in AD, murine and human aorta from patients with AD were used. A high expression levels piR-823 found AD. Using performed loss- gain-of-function assays vitro vivo, we explore regulatory effect on vascular smooth muscle cells (VSMCs) obviously facilitates proliferation, migration, phenotypic transformation VSMCs or without nicotine treatment. directly...
Acute myeloid leukemia (AML) is a prevalent malignancy of the hematologic system. Despite advancements in therapeutic approaches, significant heterogeneity and resistance pose substantial challenges to treatment. Tumors driven by core transcription factors through super-enhancers can establish transcriptional regulatory circuits (CRCs) that modulate oncogene expression programs. Identifying CRC crucial for understanding disease-related regulation. This study sought predict model AML,...
Although cholesterol metabolism is a common pathway for the development of antitumor drugs, there are no specific targets and drugs clinical use. Here, based on our previous study sterol O-acyltransferase 1 (SOAT1) in hepatocelluar carcinoma, we sought to screen an effective targeted drug precise treatment carcinoma and, from perspective metabolism, clarify relationship between regulation tumorigenesis development.In this study, developed virtual screening integrated affinity technology...
Decreased autophagy is accompanied by the development of a myeloproliferative state or acute myeloid leukemia (AML). AML cells are often sensitive to autophagy‑inducing stimuli, prompting idea that targeting can be useful in cytotoxic therapy. NB4 overexpressing microtubule-associated protein 1 light chain 3-green fluorescent were screened with 69 inhibitors analyze activity. treated polo-like kinase (PLK1) RO3280 and BI2536 before analysis. Cleaved LC3 (LC3-II) phosphorylation mammalian...
Super enhancers (SEs) are genomic regions comprising multiple closely spaced enhancers, typically occupied by a high density of cell-type-specific master transcription factors (TFs) and frequently enriched in key oncogenes various tumors, including neuroblastoma (NB), one the most prevalent malignant solid tumors children originating from neural crest. Cyclin-dependent kinase 5 regulatory subunit-associated protein 3 (CDK5RAP3) is newly identified super-enhancer-driven gene regulated TFs NB;...
Neuroblastoma (NB) is the most common extra-cranial solid tumor in childhood with overall 5 years' survival less than 40%.Polo-like kinase 1 (PLK1) a serine/threonine-protein expressed during mitosis and over multiple cancers, including neuroblastoma.We found that higher PLK1 expression related to poor outcome of NB patients.BI2536, small molecule inhibitor against PLK1, significantly reduced cell viability panel lines, IC50 100 nM.PLK1 inhibition by BI 2536 treatment induced cycle arrest at...
JOURNAL/nrgr/04.03/01300535-202412000-00028/figure1/v/2024-05-29T122840Z/r/image-tiff Immune changes and inflammatory responses have been identified as central events in the pathological process of spinal cord injury. They can greatly affect nerve regeneration functional recovery. However, there is still limited understanding peripheral immune response In this study, we obtained microRNA expression profiles from blood patients with injury using high-throughput sequencing. We also mRNA...
AbstractWe investigated the preventive efficacy of exogenous methylcobalamin on sciatic nerve IGF-1 expression down-regulation and peripheral deficit under different conditions (hyperglycemia duration) experimental diabetes in rats. Hyperglycemia was induced with streptozotocin, stratified by insulin into mild severe conditions. Duration ranged from 2–12 weeks. A single dose intramuscularly administrated. Three groups rats were compared this study: (i) control group (NC, n = 30); (ii)...
Ulcerative colitis (UC) is a form of chronic inflammatory bowel disease nonspecific origin. This study used an RNA-Sequencing (RNA-Seq) approach to evaluate the transcriptomic landscape well-stratified treatment-naïve pediatric UC patient population by comparing them with healthy control children. The data were analyzed mechanisms driving UC-related intestinal inflammation and fibrosis.Intestinal mucosal samples from five patients controls RNA-Seq, results verified qPCR. A CRISPR/Cas9 was...
Baicalin, which is a key bioactive constituent obtained from Scutellaria baicalensis, has been utilized in traditional Chinese medicine for many centuries. Although it reported that Baicalin (BA) can inhibit the replication of Hepatitis B virus (HBV), exact mechanism behind this process remains unclear. Interferon-stimulated genes (ISGs) are crucial antiviral defense. We aim to investigate whether BA regulate expression ISGs, and thereby potentially modulate HBV.The study involved use...
Background Skin flap transplantation is one of the effective methods to treat diabetes-related foot ulceration, but intrinsic damage vessels in diabetes mellitus (DM) leads necrosis skin flaps. Therefore, discovery a non-invasive and approach for promoting survival flaps utmost importance. Electrical stimulation (ES) promotes angiogenesis increases proliferation, migration, elongation endothelial cells, thus being potential method improve survival. Objective The purpose this study was...
On the basis of clinical empirical observations and classic theory platelet aggregation, microvascular surgeons have held that aggregation is more responsible for arterial thrombosis fibrin clot formation venous thrombosis. This was tested in two models thrombosis, one created arteries other veins, using systemic antithrombotic agents. The were pair matched rats, creating a crush-avulsion injury to femoral artery on leg crushing vein conbalateral leg. There four treatment groups (n = 15 per...
Hepatocellular carcinoma ( HCC ) is a common cancer with poor prognosis. Hepatitis B virus HBV one of the leading causes , but precise mechanisms by which this infection promotes development are not fully understood. Recently, miR‐340‐5p, micro RNA (mi that has been identified as suppressor gene, was found to inhibit migration and invasion liver cells. However, effect miR‐340‐5p on cell proliferation apoptosis in ‐associated remains unknown. In our study, we show plays an important role...
Alveolar echinococcosis (AE), which is caused by larval Echinococcus multilocularis, one of the world's most dangerous neglected diseases. Currently, no fully effective treatments are available to cure this disease.In vitro protoscolicidal assay along with in vivo murine models was applied repurposing drugs against AE. Genome-wide identification and homology-based modeling were used for predicting drug targets. RNAi, enzyme assay, RNA-Seq analyses utilized investigating roles parasite...
Ischemic stroke (IS) is a serious neurological disease that largely results in long-term disability and death. Extensive evidence has indicated the activation of inflammation ferroptosis significantly contribute to development IS pathology. However, underlying molecular mechanism remains unclear. In this study, we aimed identify potential biomarkers associated with through construction competing endogenous RNA (ceRNA) network investigate possible inflammatory ferroptosis-related...