A5101764587- Cancer-related gene regulation
- Crystallization and Solubility Studies
- Optical Polarization and Ellipsometry
- X-ray Diffraction in Crystallography
- Fluorine in Organic Chemistry
- Bioactive Compounds and Antitumor Agents
- Catalytic Alkyne Reactions
- Asymmetric Synthesis and Catalysis
- Protein Degradation and Inhibitors
- Catalytic C–H Functionalization Methods
- Supramolecular Self-Assembly in Materials
- Immune Cell Function and Interaction
- Nanomaterials for catalytic reactions
- S100 Proteins and Annexins
- RNA modifications and cancer
- Inorganic Fluorides and Related Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Luminescence and Fluorescent Materials
- Chronic Myeloid Leukemia Treatments
- Genomics and Chromatin Dynamics
- Ubiquitin and proteasome pathways
- Advanced Glycation End Products research
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Acute Lymphoblastic Leukemia research
Soochow University
2023-2025
Central China Normal University
2022-2024
Tianjin Medical University
2023
China University of Petroleum, East China
2021
The University of Tokyo
2021
Beijing Normal University
2017
Distinct regio- and enantioselectivity control in copper-catalyzed vinylogous bisvinylogous propargylic substitution has been accomplished by using a novel chiral N,N,P ligand. The developed method provides an efficient selective approach to array of highly enantioenriched alkynyl unsaturated carbonyl compounds. Salient features include excellent functional group tolerance broad substrate scope. synthetic utility the is further demonstrated gram-scale synthesis application range...
As part of an effort to develop generally applicable strategies for creating probes suitable detecting important molecular and ionic species, the oxidative aromatization nonfluorescent 9,10-dihydroacridine derivatives triggered by peroxynitrite (ONOO–) led identification compound 2H, 9-phenyl-9,10-dihydroacridine-4-carboxylic acid, as a rapid-responding fluorescent probe capable ONOO– with extraordinary selectivity. Adding little more than 1 equiv solution 2H resulted in over 100-fold...
The sterile inflammation caused by damage-associated molecular patterns (DAMPs) worsens the prognosis following primary injury such as ischemic stroke. However, there are no effective treatments to regulate DAMPs. Here, we report that AIM (or CD5L) protein reduces attenuating DAMPs and administration ameliorates deleterious effects of binds via charge-based interactions disulfide bond formation. This association promotes phagocytic removal neutralizes impeding their binding inflammatory...
Acute myeloid leukemia (AML) is a prevalent malignancy of the hematologic system. Despite advancements in therapeutic approaches, significant heterogeneity and resistance pose substantial challenges to treatment. Tumors driven by core transcription factors through super-enhancers can establish transcriptional regulatory circuits (CRCs) that modulate oncogene expression programs. Identifying CRC crucial for understanding disease-related regulation. This study sought predict model AML,...
Despite significant progress in the prognosis of pediatric T-cell acute lymphoblastic leukemia (T-ALL) recent decades, a notable portion children still confronts challenges such as treatment resistance and recurrence, leading to limited options poor prognosis. LIM domain-binding protein 1 (LDB1) has been confirmed exert crucial role various physiological pathological processes. In our research, we aim elucidate underlying function mechanisms LDB1 within background T-ALL.
Arising from T progenitor cells, T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignant tumor, accounting for 15% of childhood ALL and 25% adult ALL. Composing putative enhancers in close genomic proximity, super enhancer (SE) critical cell identity the pathogenesis multiple cancers. Belonging to cytosolute linker protein group, FYB1 essential TCR signaling extensively studied terms tumor metastasis. Dissecting role FYN binding 1 (FYB1) T-ALL holds potential...
A NO-response amphiphile was successfully formed into vesicles in aqueous solution, which could encapsulate and control the release of carboxyfluorescein (CF) as a model drug <italic>in vitro</italic> living cells.
In this paper, we present a theoretical analysis of the optical bistability in metallic silver-Bragg reflector structure by embedding bilayer MoS2 at visible band. The nonlinear OB is achieved due to conductivity and excitation Tamm state interface between silver Bragg reflector. It found that hysteresis behaviour threshold width can be effectively tuned varying incident light wavelength. addition, bistable adjusted position inset defect layer, angle structural parameters spacer layer....
This article theoretically proposes a multi-layer Fabry-Perot cavity structure based on nonlinear MoS2, whose is composed of asymmetric photonic crystals. In this structure, we observed low threshold optical bistability phenomenon the order in visible light band, which caused by large third-order conductivity bilayer MoS2 and resonance. Research has found that when incident from two different directions an cavity, exhibits not exactly same behavior. addition, further investigated behavior...
Here, we report a nickel-catalyzed reductive C(sp 3 )–C(sp 2 ) cross-coupling of monofluoroalkyl triflates with aryl halides, yielding series functionalized monofluoroalkylated arenes.
Abstract Neuroblastoma (NB) is a widely recognized childhood tumor with high global incidence. The regulatory role of RNA N6-methyladenosine (m6A) in gene expression has gained significant attention, and the impact methyltransferase-like 14 (METTL14) on progression been extensively investigated various cancer types. Nevertheless, precise influence METTL14 NB remains unexplored. Based data obtained from Target database, our study revealed upregulation high-risk patients, which exhibited...