A5065292706- Antibiotic Resistance in Bacteria
- Vibrio bacteria research studies
- Hearing, Cochlea, Tinnitus, Genetics
- Meat and Animal Product Quality
- Enterobacteriaceae and Cronobacter Research
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Plant Pathogenic Bacteria Studies
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Bacteriophages and microbial interactions
- Cancer-related gene regulation
- Bacterial biofilms and quorum sensing
- Salmonella and Campylobacter epidemiology
- Urban Agriculture and Sustainability
- Ultrasound and Hyperthermia Applications
- Pharmaceutical and Antibiotic Environmental Impacts
- Infections and bacterial resistance
- RNA modifications and cancer
- Aquaculture disease management and microbiota
- Plant Molecular Biology Research
- NF-κB Signaling Pathways
- Epigenetics and DNA Methylation
- Economic and Financial Impacts of Cancer
Institute of Rock and Soil Mechanics
2025
Chongqing University
2025
Hong Kong Polytechnic University
2017-2024
Eye & ENT Hospital of Fudan University
2020-2024
State Key Laboratory of Medical Neurobiology
2021-2024
Fudan University
2020-2024
Shenzhen Polytechnic
2023-2024
The First Affiliated Hospital, Sun Yat-sen University
2024
The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine
2024
Fujian Medical University
2020-2024
To analyse and compare mcr-1-bearing plasmids from animal Escherichia coli isolates, to investigate potential mechanisms underlying dissemination of mcr-1. Ninety-seven ESBL-producing E. strains isolated pig farms in China were screened for the mcr-1 gene. Fifteen mcr-1-positive subjected molecular characterization bioinformatic analysis that they harboured. Three major types recovered: IncX4 (∼33 kb), IncI2 (∼60 kb) IncHI2 (∼216–280 among which found harbour gene only, whereas multiple...
As an anti-tumor drug widely used in the clinic, cisplatin is limited by its ototoxic side effects associated with various factors, including inflammatory responses.Receptor for Advanced Glycation Endproducts (RAGE) recognizes damage-associated molecular patterns (DAMPs) and promotes stress inflammation.This study intended to determine potential behavior of HMGB1/RAGE axis after injury whether it has a protective effect inhibiting this pathway.We FPS-ZM1, RAGE inhibitor, modulate neonatal...
Cronobacter sakazakii is an opportunistic pathogen transmitted by food that affects mainly newborns, infants, and immune-compromised adults. In this study, the antibacterial activity of ferulic acid was tested against C. strains. Minimum inhibitory concentration strains determined using agar dilution method. Changes in intracellular pH, membrane potential ATP were measured to elucidate possible mechanism. Moreover, SYTO 9 nucleic staining used assess effect on bacterial integrity. Cell...
Punicalagin, one of the main active compounds in pomegranate peel, has been reported to possess many properties, including antioxidant, antimicrobial, antiviral, and immunosuppressive activities. The aim this study was investigate antibacterial effect punicalagin against Staphylococcus aureus possible mode action. Growth inhibition activity examined by agar diffusion method. Then dilution method adopted determine minimum inhibitory concentration (MIC). effects on cell membrane were assessed...
Ferroptosis is a recently recognized form of non-apoptotic cell death caused by an iron-dependent accumulation lipid hydroperoxides, which plays important roles in wide spectrum pathological conditions. The present study was aimed to investigate the impact ferroptosis on cisplatin-induced sensory hair damage. Cell viability determined Counting Kit-8 and lactase dehydrogenase assays. reactive oxygen species (ROS) levels were evaluated 2,7-Dichlorodi-hydrofluorescein diacetate (DCFH-DA)...
Carbapenem-resistant and hypervirulent K. pneumoniae (CR-HvKP) strains that have emerged recently caused infections of extremely high mortality in various countries. In this study, we discovered a conjugative plasmid encodes carbapenem resistance hypervirulence clinical ST86 K2 CR-HvKP, namely 17ZR-91. The (p17ZR-91-Vir-KPC) was formed by fusion non-conjugative pLVPK-like blaKPC-2-bearing is present dynamically with two other non-fusion plasmids. Conjugation p17ZR-91-Vir-KPC to enabled them...
Cisplatin-related ototoxicity is a critical side effect of chemotherapy and can lead to irreversible hearing loss. This study aimed assess the potential DNA methyltransferase (DNMT) inhibitor RG108 on cisplatin-induced ototoxicity. Immunohistochemistry, apoptosis assay, auditory brainstem response (ABR) were employed determine impacts injury in murine hair cells (HCs) spiral ganglion neurons (SGNs). Rhodamine 123 TMRM utilized for mitochondrial membrane (MMP) assessment. Reactive oxygen...
This study reported the clonal dissemination of OXA-232-producing sequence type 15 (ST15) carbapenem-resistant Klebsiella pneumoniae among elderly patients in China. All were immunocompromised, suffered from multiple underlying diseases, and hospitalized for a prolonged period; however, they slowly recovered on antimicrobial therapy.
Ferroptosis is a recently discovered iron-dependent form of oxidative programmed cell death distinct from caspase-dependent apoptosis. In this study, we investigated the effect ferroptosis in neomycin-induced hair loss by using selective inhibitor liproxstatin-1 (Lip-1). Cell viability was identified CCK8 assay. The levels reactive oxygen species (ROS) were determined DCFH-DA and cellROX green staining. mitochondrial membrane potential (ΔΨm) evaluated TMRM Intracellular iron lipid peroxides...
Hair cells in the inner ear have been shown to be susceptible ototoxicity from some beneficial pharmaceutical drugs, such as aminoglycosides and cisplatin. Thus, there is great interest discovering new targets or compounds that protect hair these ototoxic drugs. Epigenetic regulation closely related development; however, little known about epigenetic process of drugs-induced hearing loss. Methods: In this study, we investigated role protein arginine methyltransferase 6 (PRMT6)...
Genetic analysis of gene expression level is a promising approach for characterizing candidate genes that are involved in complex economic traits such as meat quality. In the present study, we conducted quantitative trait loci (eQTL) and allele-specific (ASE) analyses based on RNA-sequencing (RNAseq) data from longissimus muscle 189 Duroc × Luchuan crossed pigs order to identify some quality traits.Using genome-wide association study mixed linear model, identified 7192 cis-eQTL corresponding...
Background This study aimed to analyze the economics of pembrolizumab plus chemotherapy as first-line treatment in patients with esophageal squamous cell carcinoma (ESCC) and programmed death-Ligand 1 (PD-L1) combined positive score (CPS) 10 or more China. Methods Based on advanced ESCC KEYNOTE-590 clinical trial data, a Markov model was performed simulate course evaluate patient's total lifetime, costs, quality-adjusted life-years (QALYs), incremental cost-effectiveness ratio (ICER) for...
Abstract It has been claimed that salvianolic acid B (Sal B), a natural bioactive antioxidant, exerts protective effects in various types of cells. This study aims to evaluate the antioxidant and anti‐apoptosis Sal cultured HEI‐OC1 cell line transgenic zebrafish ( Brn3C : EGFP). A CCK‐8 assay, Annexin V Apoptosis Detection Kit, TUNEL caspase‐3/7 staining, respectively, examined apoptosis viability. The levels reactive oxygen species (ROS) were evaluated by CellROX MitoSOX Red staining. JC‐1...
Background: This study aimed to analyze the cost effectiveness of camrelizumab in second-line treatment advanced or metastatic esophageal squamous cell carcinoma China. Methods: On basis ESCORT clinical trial, a partitioned survival model was constructed simulate patient’s lifetime quality-adjusted life years (QALYs), costs, and incremental cost-effectiveness ratio (ICER). One-way sensitivity probability analyses were performed test stability model. Results: Treatment with added 0.36 QALYs...
The study aimed to investigate the potential role of lysine-specific demethylase 5A (KDM5A) in cisplatin-induced ototoxicity. effect KDM5A inhibitor CPI-455 was assessed by apoptosis assay, immunofluorescence, flow cytometry, seahorse respirometry and auditory brainstem response test. RNA sequencing, qRT-PCR, CUT&Tag assays were used explore mechanism underlying CPI-455-induced protection. Our results demonstrated that expression increased cisplatin-injured cochlear hair cells compared with...
Fracturing is an indispensable technique in geothermal energy development. Large-sized model tests of different fracturing methods are crucial for evaluating the effect and extrapolating results to field applications. For common hydraulic deflagration methods, 40 × cm3 granite samples were used carry out under high-temperature conditions this paper. Through analysis parameters multiscale fracture morphology, a series key findings summarized. Deflagration more intense, notably unaffected by...