A5100368230- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Photosynthetic Processes and Mechanisms
- Neuroendocrine Tumor Research Advances
- Lung Cancer Diagnosis and Treatment
- Genomics and Phylogenetic Studies
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Esophageal and GI Pathology
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- RNA Research and Splicing
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Colorectal Cancer Screening and Detection
- Plant Stress Responses and Tolerance
- Sepsis Diagnosis and Treatment
- Influenza Virus Research Studies
Suizhou Central Hospital
2021-2025
China Medical University
2019-2025
Tianjin Children's Hospital
2025
Tianjin University
2025
Guangzhou University of Chinese Medicine
2025
Henan University of Science and Technology
2022-2024
First Affiliated Hospital of Kunming Medical University
2021-2024
First Hospital of Jilin University
2024
Jilin University
2024
Second Hospital of Anhui Medical University
2012-2024
Subacute combined degeneration (SCD) is a relatively rare myelopathy mainly caused by vitamin B12 (VitB12) deficiency. There are many causes contributing to VitB12 Autoimmune gastritis might lead severe malabsorption and in its advanced stage pernicious anemia (PA) may occur. Besides, long-term hypergastrinemia arising from achlorhydria autoimmune associated with neuroendocrine tumors (NETs). Patients diagnosed SCD coexistent PA NET seldomly reported. We describe 34-year-old woman an initial...
To evaluate sintilimab versus placebo in combination with chemotherapy (cisplatin plus paclitaxel or cisplatin 5-fluorouracil) as first line treatment of unresectable locally advanced, recurrent, metastatic oesophageal squamous cell carcinoma.Multicentre, randomised, double blind, phase 3 trial.66 sites China and 13 outside between 14 December 2018 9 April 2021.659 adults (aged ≥18 years) advanced carcinoma who had not received systemic treatment.Participants were randomised 1:1 to receive...
Plants that grow in extreme environments represent unique sources of stress-resistance genes and mechanisms. Ammopiptanthus mongolicus (Leguminosae) is a xerophytic evergreen broadleaf shrub native to semi-arid desert regions; however, its drought-tolerance mechanisms remain poorly understood. Here, we report the assembly reference-grade genome for A. mongolicus, describe evolutionary history within legume family, examine The assembled 843.07 Mb length, with 98.7% sequences successfully...
Abstract This is a randomized, double-blind, placebo-controlled phase 3 clinical trial (ClinicalTrials.gov, NCT04878016) conducted in 54 hospitals China. Adults who were histologically diagnosed and never treated for extensive-stage small cell lung cancer (ES-SCLC) enrolled. Eligible Patients randomly assigned (1:1) to receive four cycles (21 days as one cycle) of intravenous carboplatin (area under the curve 5 mg/mL per min, day 1 each etoposide (100 mg/m² body-surface area, on 1–3 with...
Female breast cancer (FBC) has become the most prevalent malignancy worldwide. We aimed to evaluate global and regional burden in epidemiological trends factors associated with incidence mortality of FBC.FBC 60 selected countries by registry data integrity 2020 were estimated from GLOBOCAN database, their association human development index (HDI) was further evaluated. Trends age-standardized rates 2000 through 2019 evaluated joinpoint regression analysis using Global Burden Disease 2019....
Globally, colorectal cancer (CRC) imposes a substantial burden on healthcare systems and confers considerable medical expenditures. We aimed to evaluate the global regional in epidemiological trends factors associated with incidence mortality of CRC.We used data from GLOBOCAN database estimate CRC worldwide 2020 their association human development index (HDI). Trends age-standardized rates 60 countries (2000-2019) were evaluated by Joinpoint regression analysis using Global Burden Disease...
Accumulation of DNA damage in the lung induces cellular senescence and promotes age-related diseases such as idiopathic pulmonary fibrosis (IPF). Hence, understanding mechanistic regulation repair is important for anti-aging therapies disease control. Here, we identified an m6A-independent role RNA-binding protein YTHDC1 counteracting stress-induced fibrosis. primarily expressed alveolar epithelial type 2 (AECII) cells its AECII expression significantly decreased AECIIs during Exogenous...
Immunotherapies that targeting programmed cell death 1 (PD-1) and death-ligand (PD-L1) have obtained prominent success in breast cancer (BC). However, not all the patients benefit from antibody therapy. This study aimed to identify PD-1/PD-L1 correlated genes pathways as well investigate their potential prognostic marker BC.By analysing transcriptional data of BC TCGA, we identified PD-1 PD-L1 by WGCNA analysis explored biological process they enriched. Co-expression were performed for with...
Summary Clarifying the evolutionary processes underlying species diversification and adaptation is a key focus of biology. Begonia (Begoniaceae) one most species‐rich angiosperm genera with c . 2000 species, which are shade‐adapted. Here, we present chromosome‐scale genome assemblies for four ( B. loranthoide s, masoniana , darthvaderiana peltatifolia ), whole shotgun data an additional 74 representatives to investigate lineage evolution shade genus. The range in size from 331.75 Mb ) 799.83...
Abstract Purpose To evaluate the treatment outcome of salvage concurrent radio-chemotherapy for patients with loco-recurrent esophageal cancer after surgery. Methods 50 squamous-cell curative esophagectomy were retrospectively analyzed. Patients treated radiotherapy (median 60 Gy) combined chemotherapy consisting either 5-fluorouracil (5-FU) plus cisplatin (DDP) (R-FP group) or paclitaxel DDP (R-TP group). Results The median follow-up period was 16.0 months. 1-year and 3-year survival rates...
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressively malignant tumors with dismal prognosis. Profilin 2 (PFN2) an actin-binding protein that regulates dynamics actin polymerization and plays a key role in motility. Recently, PFN2 have emerged as significant regulators cancer processes. However, clinical significance biological function ESCC remain unclear. expression was validated by immunohistochemistry (IHC) on tissue microarray from Chinese Han Kazakh populations...
Background: This study aimed to analyze the cost effectiveness of camrelizumab in second-line treatment advanced or metastatic esophageal squamous cell carcinoma China. Methods: On basis ESCORT clinical trial, a partitioned survival model was constructed simulate patient’s lifetime quality-adjusted life years (QALYs), costs, and incremental cost-effectiveness ratio (ICER). One-way sensitivity probability analyses were performed test stability model. Results: Treatment with added 0.36 QALYs...
Accumulating evidence indicates that immunotherapy helped to improve the survival and quality-of-life of patients with lung adenocarcinoma (LUAD) or squamous cell carcinoma (LUSC) besides chemotherapy gene targeting treatment. This study aimed develop immune-related signatures in LUAD LUSC subtypes, respectively. samples were divided into high- low-abundance groups immune infiltration (Immunity_H Immunity_L) based on abundance infiltrations. The distribution cells was significantly different...
Background Ovarian cancer (OC) is a female reproductive system tumor. RNA modifications play key roles in gene expression regulation. The growing evidence demonstrates that methylation critical for various biological functions, and its dysregulation related to the progression of human. Method OC samples were classified into different subtypes (Clusters 1 2) based on RNA-modification regulatory genes (RRGs) process (m1A, m6A, m6Am, m5C, m7G, ac4C, m3C, Ψ) by nonnegative matrix factorization...
Flowering cherry is a very popular species around the world. High-quality genome resources for different elite cultivars are needed, and understanding of their origins regulation key ornamental traits limited this tree. Here, high-quality chromosome-scale Prunus campanulata 'Plena' (PCP), which native flowering cultivar in China, was generated. The contig N50 18.31 Mb, 99.98% its contigs were anchored to eight chromosomes. Furthermore, total 306 accessions germplasm six lines outgroups...
Abstract Background To construct and assess a computed tomography (CT)-based deep learning radiomics nomogram (DLRN) for predicting the pathological grade of bladder cancer (BCa) preoperatively. Methods We retrospectively enrolled 688 patients with BCa (469 in training cohort, 219 external test cohort) who underwent surgical resection. extracted handcrafted (HCR) features (DL) from three-phase CT images (including corticomedullary-phase [C-phase], nephrographic-phase [N-phase]...
Recently, a lot of Chinese patients consult treatment plans through social networking platforms, but the medical text contains rich information, including large number nomenclatures and symptom descriptions. How to build an intelligence model automatically classify information consulted by recommend correct department for is very important. In order address problem insufficient feature extraction from low accuracy, this paper proposes dual channel classification model. The extracts at...
Objective Our study aimed to update demographic profiles of sinonasal adenocarcinoma (SNAC) between 2000 and 2020, identify independent prognostic risk factors, devise a predictive nomogram for overall survival (OS). Methods Utilizing the Surveillance, Epidemiology, End Results (SEER) database, cases SNAC from 2020 were analyzed incidence trends. Univariate multivariate Cox regression models helped pinpoint factors impacting patient survival. A was then created based on these assessed via...