A5018188959- Diabetes Management and Research
- Glycosylation and Glycoproteins Research
- Cancer-related molecular mechanisms research
- Microtubule and mitosis dynamics
- RNA Research and Splicing
- Hedgehog Signaling Pathway Studies
- RNA Interference and Gene Delivery
- Pancreatic function and diabetes
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- Diabetes and associated disorders
- Glioma Diagnosis and Treatment
Guangdong Provincial People's Hospital
2024
Guangdong Academy of Medical Sciences
2024
Sun Yat-sen University
2023
Accumulation of DNA damage in the lung induces cellular senescence and promotes age-related diseases such as idiopathic pulmonary fibrosis (IPF). Hence, understanding mechanistic regulation repair is important for anti-aging therapies disease control. Here, we identified an m6A-independent role RNA-binding protein YTHDC1 counteracting stress-induced fibrosis. primarily expressed alveolar epithelial type 2 (AECII) cells its AECII expression significantly decreased AECIIs during Exogenous...
Chemotherapy-induced peripheral neuropathy (CIPN) is a common complication that affects an increasing number of cancer survivors. However, the current treatment options for CIPN are limited. Paclitaxel (PTX) widely used chemotherapeutic drug induces senescence in cells. While previous studies have demonstrated Sonic hedgehog (Shh) can counteract cellular dysfunction during aging, its role remains unknown. Herein, aim this study was to investigate whether Shh activation could inhibits...