A5100358566- Parasitic Infections and Diagnostics
- Toxoplasma gondii Research Studies
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- MicroRNA in disease regulation
- Genetics and Neurodevelopmental Disorders
- Pharmacological Effects and Toxicity Studies
- Metabolism, Diabetes, and Cancer
- Neuropeptides and Animal Physiology
- Spinal Fractures and Fixation Techniques
- Vascular Malformations Diagnosis and Treatment
- Diet and metabolism studies
- Cerebrospinal fluid and hydrocephalus
- Antioxidant Activity and Oxidative Stress
- Immune cells in cancer
- Organ Transplantation Techniques and Outcomes
- Histone Deacetylase Inhibitors Research
- Meningioma and schwannoma management
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- Lung Cancer Treatments and Mutations
- Kidney Stones and Urolithiasis Treatments
Chengdu University of Technology
2025
Qilu Hospital of Shandong University
2025
First Affiliated Hospital of Kunming Medical University
2024
Kunming Medical University
2024
Central South University
2014-2024
Xiangya Hospital Central South University
2014-2024
China Pharmaceutical University
2024
Zhejiang University
2018-2024
First Affiliated Hospital Zhejiang University
2018-2024
Hunan Provincial Center for Disease Control and Prevention
2024
To evaluate sintilimab versus placebo in combination with chemotherapy (cisplatin plus paclitaxel or cisplatin 5-fluorouracil) as first line treatment of unresectable locally advanced, recurrent, metastatic oesophageal squamous cell carcinoma.Multicentre, randomised, double blind, phase 3 trial.66 sites China and 13 outside between 14 December 2018 9 April 2021.659 adults (aged ≥18 years) advanced carcinoma who had not received systemic treatment.Participants were randomised 1:1 to receive...
Abstract Background Eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) have been suggested to prevent the development of metabolic disorders. However, their individual role in treating hyperglycemia mechanism action regarding gut microbiome metabolome context diabetes remain unclear. Results Supplementation DHA EPA attenuated insulin resistance without changing body weight db/db mice while ameliorative effect appeared be more pronounced for EPA. DHA/EPA supplementation reduced abundance...
OBJECTIVE We conducted a randomized, double-blind, placebo-controlled phase 2 trial to evaluate the efficacy and safety of mazdutide, once-weekly glucagon-like peptide 1 glucagon receptor dual agonist, in Chinese patients with type diabetes. RESEARCH DESIGN AND METHODS Adults diabetes inadequately controlled diet exercise alone or stable metformin (glycated hemoglobin A1c [HbA1c] 7.0–10.5% [53–91 mmol/mol]) were randomly assigned receive 3 mg mazdutide (n = 51), 4.5 49), 6 1.5 open-label...
Background: Metabotropic glutamate receptors (mGluRs) are G-protein-coupled that mediate neuronal excitability and synaptic plasticity in the central nervous system, emerging evidence suggests a role of mGluRs biology cancer. Previous studies showed mGluR1 was potential therapeutic target for treatment breast cancer melanoma, but its human glioma has not been determined. Methods: In present study, we investigated effects inhibition U87 cells using specific targeted small interfering RNA...
Porphyromonas gingivalis (P. gingivalis) is a keystone pathogen in periodontitis. However, several clinical studies have revealed an enrichment of P. the stool samples and colorectal mucosa cancer patients. Thus, goal this study was to determine whether can promote progression vitro. We established acute infection model (24 h, multiplicity =100) invasion cells alterations induced by proliferation cell cycle cells. observed that adhere invade host few hours after infection. Once invaded,...
Abstract Background The regulatory roles of long non-coding RNA (lncRNA) CRNDE in temozolomide (TMZ) chemoresistance to glioblastoma multiforme (GBM) are still poorly understood. Therefore, the function, characteristics, and possible mechanism TMZ-induced GBM were explored. Methods Firstly, expression level 58 cases glioma tissue specimens 30 normal brain tissues tested by qRT-PCR. Meanwhile, correlation between level, clinicopathological survival time patients with analyzed. Then, various...
Pleurotus ostreatus (PO), a common edible mushroom, contains rich nutritional components with medicinal properties. To explore the effect of PO on ameliorating obesity and modulating gut microbiota, we administered mice low-fat diet or high-fat containing different dosages (mass fraction: 0%, 2.5%, 5% 10%). The body weight, adipose tissue GTT, ITT, blood lipids, serum biomarkers liver/kidney function, microbiota function were measured analyzed after 6 weeks treatment. results showed...
Valproic acid (VPA), an established antiepileptic drug, was assessed for antitumor activity, including its effects on glioblastoma, but role has not been determined.In the present study, we investigated VPA-induced apoptosis human U87 cells by cell viability, lactate dehydrogenase (LDH) release, TUNEL/Hoechst staining and flow cytometric in vitro, then further explored underlying molecular mechanisms using selective antagonists PD98059, LY294002 SB216763.The data showed that VPA...
Obesity is associated with disrupted energy homeostasis and intestinal dysbiosis. Caulis Spatholobi, traditional Chinese medicine for herbal therapy, contains a wide range of bioactive compounds has specific pharmacological function. However, its effects on obesity related metabolic disorder have remained largely unexplored. In this study, we showed that the water extract Spatholobi (WECS) significant effect in inhibiting body weight gain, decreasing adiposity, maintaining glucose...
Abstract Temozolomide (TMZ) is the internationally recognized and preferred drug for glioma chemotherapy treatment. However, TMZ resistance in appears after long-term use an urgent problem that needs to be solved. Circular RNAs (circRNAs) are noncoding play important role pathogenesis progression of tumors. Hsa_circ_0110757 was identified TMZ-resistant cells by high-throughput sequencing analysis derived from reverse splicing myeloid cell leukemia-1 (Mcl-1) exons. The hsa_circ_0110757...
Abstract Black soybean peels (BSPs) are rich in anthocyanins (ANCs), a naturally active substance added to manufactured foods. However, the instability of ANC structure limits its application food industry. In present study, an efficient and simple microencapsulation method improve stability was successfully established. BSP ANCs were encapsulated microencapsulated complex with fructo‐oligosaccharide (FOS) whey protein (WP) associated high encapsulation rate (65.41%) drug‐loading capacity...
Brown adipose tissue (BAT) is a promising potential therapeutic target for the treatment of obesity and related metabolic diseases. Allicin, natural product in garlic, has multiple biological pharmacological functions. However, role allicin regulation organs, particularly BAT activation, not been well studied. Here, we show that imparts significant effect by inhibiting body weight gain, decreasing adiposity, maintaining glucose homeostasis, improving insulin resistance, ameliorating hepatic...
Tafolecimab, a fully human proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibody developed for the treatment of hypercholesterolemia, demonstrated robust lipid-lowering efficacy and favorable safety in previous short-term studies. We aimed to assess long-term tafolecimab Chinese non-familial hypercholesterolemia (non-FH) patients. Non-FH patients at high or very-high cardiovascular risk with screening low-density lipoprotein cholesterol (LDL-C) level ≥1.8 mmol/L non-FH...
Purpose: AHNAK is originally identified as a giant protein based on the estimated size of approximately 700 kDa.The aim this study to identify role in pathogenesis glioma.Methods: We tested mRNA level panel six human glioma cell lines, and 30 cases normal brain tissues 73 tissue samples using qRT-PCR method.Further, we analyzed relationship expression with clinicopathological characteristics patients.Meanwhile, survival patients analyses.Then, vitro, biological effects lines (U87 U251)...
Petroclival meningiomas (PCMs) are regarded as one of the most formidable challenges in neurosurgery. We retrospectively assessed surgical outcomes PCMs based on a tumor classification to evaluate long-term outcomes. A series 168 patients with from July 1996 January 2017. On basis difference origin dural attachment and patterns growth, were classified into 4 different types. The clinical characteristics, record, follow-up data each type reviewed. study included 138 females (82.1%) an average...
Our study explores how CEOs’ educational attainment affects green innovation at the enterprise level and whether CEO can improve performance. To date, few studies have used environmental patents of listed companies to measure micro-level. Furthermore, existing rarely considered heterogeneity type or social responsibility institutional intervention. Thus, by using a fixed-effects model, we argue that there is positive relationship between innovation. Additionally, education significantly...
There has been a shift in focus toward environmentally and economically sustainable forms of economic growth known as High-quality development (HQED). However, this study analyzes the impact tourism (TD) renewable energy consumption on HQED 30 provinces China, while covering time period from 2007 to 2021. TD measured with help Global Moran Index. This used dynamic spatial Durbin model (SDM) measure index along green finance, foreign direct investment education. The findings empirical...
Amyloid-β oligomers (AβOs), crucial toxic proteins in early Alzheimer's disease (AD), precede the formation of Aβ plaques and cognitive impairment. In this context, we present our iterative process for developing novel near-infrared fluorescent (NIRF) probes specifically targeting AβOs, aimed at AD diagnosis. An initial screening identified compound
Neuroblastoma (NB) is the most common extracranial malignant solid tumor seen in children and continues to lead death of many pediatric cancer patients. The poor outcome high risk NB largely attributed development chemoresistant cells. Doxorubicin (dox) has been widely employed as a potent anti-cancer agent chemotherapeutic regimens; however, it also leads chemoresistance types including NB. Thus, developing novel small molecules that can overcome dox-induced promising strategy therapy. Here...