A5014804734- Cholesterol and Lipid Metabolism
- Fatty Acid Research and Health
- Experimental Behavioral Economics Studies
- Diet and metabolism studies
- Click Chemistry and Applications
- Ubiquitin and proteasome pathways
- Diet, Metabolism, and Disease
- Irrigation Practices and Water Management
- Food Chemistry and Fat Analysis
- Enzyme Catalysis and Immobilization
- Phytochemicals and Antioxidant Activities
- Soil Carbon and Nitrogen Dynamics
- Edible Oils Quality and Analysis
- Natural product bioactivities and synthesis
- Soil and Water Nutrient Dynamics
- Eicosanoids and Hypertension Pharmacology
- Peptidase Inhibition and Analysis
- Ionic liquids properties and applications
- Free Radicals and Antioxidants
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- Lipid metabolism and biosynthesis
- Protein Degradation and Inhibitors
- Genetics, Aging, and Longevity in Model Organisms
- Gallbladder and Bile Duct Disorders
Heilongjiang University of Chinese Medicine
2023-2025
Sun Yat-sen University
2024-2025
Westlake University
2024-2025
Shanghai Jiao Tong University
2021-2025
Shanghai First People's Hospital
2024-2025
Chongqing Medical University
2025
Hangzhou First People's Hospital
2025
Zhejiang University
2015-2024
Henan University of Technology
2015-2024
University of Electronic Science and Technology of China
2024
Abstract Background Eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) have been suggested to prevent the development of metabolic disorders. However, their individual role in treating hyperglycemia mechanism action regarding gut microbiome metabolome context diabetes remain unclear. Results Supplementation DHA EPA attenuated insulin resistance without changing body weight db/db mice while ameliorative effect appeared be more pronounced for EPA. DHA/EPA supplementation reduced abundance...
Rationale: Evidence linking saturated fat intake with cardiovascular health is controversial. The associations of unsaturated fats total and disease (CVD) mortality remain inconsistent, data about non-CVD are limited. Objective: To assess dietary in relation to cause-specific mortality. Methods Results: We analyzed 521 120 participants aged 50 71 years from the National Institutes Health-American Association Retired Persons Diet Health Study 16 follow-up. Intakes fatty acids (SFAs),...
To assess the individual effects of dietary eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) on insulin resistance (IR), gut microbiome, metabolites in high-fat-diet-induced obese (DIO) mice.DIO mice are fed an either high-fat diet (HFD), EPA (1% w/w) enriched HFD, or DHA wt/wt) HFD for 15 weeks. Both supplements reverse hyperglycemia IR but do not affect body weight DIO while exhibits a more pronounced ameliorative effect male mice. EPA- DHA-enriched Lactobacillus short-chain fatty...
Activity-based E2 conjugating enzyme (E2)-ubiquitin (Ub) probes have recently emerged as effective tools for studying the molecular mechanism of E3 ligase (E3)-catalyzed ubiquitination. However, preparation existing activity-based E2-Ub depends on recombination technology and bioconjugation chemistry, limiting their structural diversity. Herein we describe an expedient total chemical synthesis variant through a hydrazide-based native ligation, which enabled construction structurally new...
Glycogen synthase kinase-3 (GSK-3) dysregulation has been implicated in nigral dopaminergic neurodegeneration, one of the main pathological features Parkinson's disease (PD). The two isoforms, GSK-3α and GSK-3β, have both suggested to play a detrimental role neuronal death. To date, several studies focused on GSK-3β PD pathogenesis, while largely overlooked. Here, we report
Sesame seed is rich in sesamin. The present study was to (i) investigate the plasma cholesterol-lowering activity of dietary sesamin and (ii) examine interaction with gene expression sterol transporters, enzymes, receptors, proteins involved cholesterol metabolism. Thirty hamsters were divided into three groups fed control diet (CON) or one two experimental diets containing 0.2% (SL) 0.5% (SH) sesamin, respectively, for 6 weeks. Plasma total (TC) levels given CON, SL, SH 6.62 ± 0.40, 5.32...
// Jingnan Chen 1 , Yan Wei Xinyu Jingjing Jiao 2 and Yu Zhang Department of Food Science Nutrition, College Biosystems Engineering Science, Zhejiang University, Hangzhou, Zhejiang, China School Public Health, University Medicine, Correspondence to: Zhang, email: Jiao, Keywords : polyunsaturated fatty acids, anti-aging, redox, telomere protection, antioncogene, Gerotarget Received October 24, 2016 Accepted December 20, Published 26, Abstract Polyunsaturated acids (PUFA), a group nourishing...
It is a well-documented phenomenon that group's gender composition can impact group performance. Understanding why and how this happens prominent puzzle in the literature. To shed light on puzzle, we propose experimentally test one novel theory: through salience of stereotype, affects person's willingness to lead group, thereby impacting overall By randomly assigning people groups with varying compositions, find women mixed-gender are twice as likely single-gender suffer from stereotype...
The differences in sterol chemical structures influenced the membrane characteristics of liposomes, especially physicochemical changes during storage. Therefore, effects sterols (cholesterol, β-sitosterol, and stigmasterol) on were investigated compared with liposomes without sterols. incorporation increased particle size liposomes. Transmission electron microscopy images showed that improved rigidity decreased deformability membranes. Cholesterol produced a more condensing effect membranes,...
Wild melon (Cucumis melo var. agrestis) seed oil (CO) contains 71.3% polyunsaturated fatty acids. The present study investigated the effects of CO on blood cholesterol and gut microbiota. Hamsters (n = 32) were randomly divided into four groups given one diets, namely noncholesterol diet (NCD), high-cholesterol containing 0.1% (HCD), HCD 4.75% (COL), 9.5% (COH) for 6 weeks. supplementation at in reduced plasma by 24% enhanced excretion fecal bile acids 150%. upregulated gene expression...
Photocaged, activity-based ubiquitin (Ub) probes (Ub-ABPs) have been developed for the time-resolved probing of deubiquitinating enzyme (DUB) activities, but many Ub-ABPs are still challenging to photocage because their warheads (e.g. propargylamide (PA) or dehydroalanine (Dha)) difficult temporally block and activate. Here, we describe a new C-terminal backbone modification strategy construction photocaged in which light-sensitive group is placed at amide bond Ub Gly75. This enabled facile...
Objective The purpose of this research is to establish a prognostic nomogram for patients with distal cholangiocarcinoma (dCCA). Methods We obtained clinical data from 2401 diagnosed (dCCA) between 2010 and 2020 the Surveillance, Epidemiology, End Results database. These were randomly assigned either training or validation group in ratio 6:4. 228 enrolled 9 hospitals China as external cohort. Univariate multifactorial Cox regression analyses conducted ascertain factors nomograms developed...
Pharmacokinetic studies can provide a method for optimizing preparations. In this study, three most abundant compounds from Fritillaria ussuriensis bulb were isolated, and selective, sensitive new analytical was developed. This aims the simultaneous determination of peimisine-3-O-β-D-glucopyranoside (1), karelinine (2), peimisine (3) in rat plasma after oral administration F. powder (FUP), total alkaloid extract (FUE), its nanodispersion preparation (FUN) using UHPLC-MS/MS. The...
Post-stroke rehabilitation exercise is recognized as the most effective and preferred intervention to reduce disability rates in patients. However, adherence low among stroke Previous research has mainly focused on negative psychological factors influencing adherence, while positive aspects remain underexplored. Therefore, this study aims investigate exercises acute patients, especially factors, order rate of stroke. From October 2023 March 2024, a total 227 patients with were selected from...
ABSTRACT Polyunsaturated fatty acids (PUFA) have been proposed to be involved in the diabetes etiology, but associations between PUFA biomarkers and glycemic dynamics are unclear. We aimed investigate prospective of with assessed by continuous glucose monitoring (CGM). A total 1216 middle‐aged elderly participants were included. performed a multivariable‐adjusted linear regression association baseline measurement erythrocyte follow‐up CGM profiles. During median 13.6‐year follow‐up, highest...