A5081883023- Catalytic Processes in Materials Science
- Electrocatalysts for Energy Conversion
- Advanced Photocatalysis Techniques
- Catalysis and Oxidation Reactions
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal-Organic Frameworks: Synthesis and Applications
- Gas Sensing Nanomaterials and Sensors
- Catalysis and Hydrodesulfurization Studies
- Ammonia Synthesis and Nitrogen Reduction
- Hydrogen Storage and Materials
- RNA modifications and cancer
- CAR-T cell therapy research
- Luminescence and Fluorescent Materials
- Aerogels and thermal insulation
- Polyoxometalates: Synthesis and Applications
- Catalysts for Methane Reforming
- Hybrid Renewable Energy Systems
- Molecular Sensors and Ion Detection
- Covalent Organic Framework Applications
- Cancer Mechanisms and Therapy
- Medical Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Cardiovascular Health and Risk Factors
- Cancer Immunotherapy and Biomarkers
Peking University
2016-2025
Peking University Cancer Hospital
2022-2025
Nanjing Forestry University
2008-2025
South China University of Technology
2019-2025
Xijing Hospital
2024
Air Force Medical University
2024
Hunan Children's Hospital
2022-2023
China Southern Power Grid (China)
2023
Zhejiang Cancer Hospital
2023
Huazhong University of Science and Technology
2023
Amino acids metabolism, especially aspartate is often altered in human cancers including hepatocellular carcinoma (HCC) and this metabolic remodeling required for supporting cancer cell malignant activities. Argininosuccinate synthase 1 (ASS1), as a crucial rate-limiting enzyme participates repressing tumor progression. However, the roles of long noncoding RNAs (lncRNAs) metabolism underlying mechanisms remain unclear. Here, we screen LINC01234 an metabolism-related lncRNA HCC. Clinically,...
The cooperative catalysis between noble metals and oxygen vacancies in reducible oxides plays an important role many heterogeneous catalytic reactions, but definite identification of active sites remains challenging. Herein, we report experimental HCHO oxidation over TiO2-supported Pt catalysts by means microscopic spectroscopic techniques. Pt/TiO2–x with tunable vacancy concentrations were designed fabricated based on hydrogen spillover. A combination aberration-corrected scanning...
Chimeric antigen receptor modified T cells (CAR-T) therapy is an emerging immunotherapy against malignancies. However, only limited success was obtained in solid tumors. Polyinosinic-polycytidylic acid (poly I:C), ligand of TLR3, mediates innate immune and adaptive shows broad antitumor effect on many types cancer. In the present study, we combined EGFRvIII-targeted CAR-T with poly I:C treatment evaluated synergic vitro immunocompetent mice bearing subcutaneous colon or orthotopic breast...
Triple-negative breast cancer (TNBC) is the most aggressive subtype, with limited treatment options. Epidermal growth factor receptor (EGFR) reported to be expressed in 50%-75% of TNBC patients, making it a promising target for treatment. Here we show that EGFR-targeted chimeric antigen (CAR) T cell therapy combined radiotherapy provides enhanced antitumor efficacy immunocompetent and immunodeficient orthotopic mice. Intriguingly, this combination resulted substantial increase number...
Synthesis of buckybowls have stayed highly challenging due to the large structural strain caused by curved π surface. In this paper, we report synthesis and properties two trichalcogenasupersumanenes which three chalcogen (sulfur or selenium) atoms methylene groups bridge at bay regions hexa-peri-hexabenzocoronene. These are synthesized quickly in steps using an Aldol cyclotrimerization, a Scholl oxidative cyclization, Stille type reaction. X-ray crystallography analysis reveals that they...
Catalytic decomposition of the hydrogen-rich hydrazine monohydrate (N2H4·H2O) represents a promising hydrogen storage/production technology. A rational design advanced N2H4·H2O catalysts requires an overall consideration intrinsic activity, number, and accessibility active sites. We herein report synthesis hierarchically nanostructured NiPt/N-doped carbon catalyst using three-step method that can simultaneously address these issues. The chelation metal precursors with polydopamine...
Chimeric antigen receptor (CAR) T cell therapy has shown remarkable success in hematological tumors. However, many challenges remain improving the efficacy of CAR cells solid The epidermal growth factor variant III (EGFRvIII) is only expressed tumors but barely found normal tissues, making it a good target for therapy. It reported that 31–64% glioblastoma (GBM) patients are EGFRvIII positive. Here we report robust antitumor activities targeting EGFRvIII-expressing mouse GBM cells. In vitro...
An efficient chemical reduction protocol has been developed for the synthesis of hyaluronic acid-coated silver nanoparticles (HA-Ag NPs) that are spherical, ultrasmall and monodisperse. The as-synthesized HA-Ag NPs not only exhibited excellent long-term stability low cytotoxicity but also could be used as a nanoplatform X-ray computed tomography (CT) single-photon emission (SPECT) imaging after being radiolabeled with 99mTc.
Families of bio-based hyperbranched epoxy (HBPEEs) were successfully prepared using renewable xylitol, bisphenol A and epichlorohydrin as feedstocks. The structure physical performances HBPEEs characterized by FTIR, NMR, GPC viscosity evaluation. Then, they used high efficient tougheners for diglycidyl A/diethylenetriamine (DGEBA/DETA) networks. results indicated that the incorporation into DGEBA system can significantly enhance mechanical properties solvent resistance hybrid (HBPEEs/DGEBA)....
Abstract Background Palliative care has become a key medical field worldwide. Although research relating to adult palliative is well-established, less known about children’s (CPC). Therefore, this study investigated the knowledge, attitude and behavior of pediatric healthcare workers (PHWs) regarding CPC analyzed influencing factors for implementation development CPC. Methods A cross-sectional survey 407 PHWs was carried out in Chinese province from November 2021 April 2022. The...