A5018751623- Bone Metabolism and Diseases
- Spinal Cord Injury Research
- Spine and Intervertebral Disc Pathology
- RNA modifications and cancer
- Immune cells in cancer
- Pregnancy-related medical research
- Cancer, Hypoxia, and Metabolism
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- Inflammatory mediators and NSAID effects
- Bone health and treatments
- Pain Mechanisms and Treatments
- TGF-β signaling in diseases
- Neural and Behavioral Psychology Studies
- Angiogenesis and VEGF in Cancer
- Nerve injury and regeneration
- Extracellular vesicles in disease
- Folate and B Vitamins Research
- Creativity in Education and Neuroscience
- Bone health and osteoporosis research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell Adhesion Molecules Research
- Peroxisome Proliferator-Activated Receptors
- Mitochondrial Function and Pathology
- Musculoskeletal pain and rehabilitation
Shanghai Changzheng Hospital
2021-2024
Soochow University
2024
First Affiliated Hospital of Soochow University
2024
Wenzhou Medical University
2016-2024
Ruian People's Hospital
2024
Second Military Medical University
2021-2022
Lanzhou University of Technology
2021
Nanjing Medical University
2018-2020
Jiangsu Province Hospital
2018-2020
First Affiliated Hospital of Wenzhou Medical University
2016
Abstract Spinal cord injury (SCI) can cause severe irreversible motor dysfunction and even death. Neural stem cell (NSC) transplantation promote functional recovery after acute SCI in experimental animals, but numerous issues, including low-transplanted survival rate, de-differentiation, tumor formation need to be resolved before routine clinical application is feasible. Recent studies have shown that transplanted cells facilitate regeneration through release of paracrine factors. Small...
Approximately 10% of bone fractures do not heal satisfactorily, leading to significant clinical and socioeconomic implications. Recently, the role macrophages in regulating marrow stem cell (BMSC) differentiation through osteogenic pathway during fracture healing has attracted much attention. Methods: The tibial monocortical defect model was employed determine critical macrophage scavenger receptor 1 (MSR1) intramembranous ossification (IO) vivo. potential functions mechanisms MSR1 were...
Increasing studies have reported that intervertebral disc degeneration (IVDD) is the main contributor and independent risk factor for low back pain (LBP), it would be, therefore, enlightening investigating exact pathogenesis of IVDD developing target-specific molecular drugs in future. Ferroptosis a new form programmed cell death characterized by glutathione (GSH) depletion, inactivation regulatory core antioxidant system (glutathione system) GPX4. The close relationship oxidative stress...
Aims: In the NOD-like receptor (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome is closely related to progression of atherosclerosis. This study aimed assess effects curcumin on NLRP3 in phorbol 12-myristate 13-acetate (PMA)-induced macrophages and explore its underlying mechanism. Methods: Human monocytic THP-1 cells were pretreated with for 1 h subsequently induced PMA 48 h. Total protein was collected Western blot analysis. Cytokine interleukin (IL)-1β release nuclear factor...
Ischemia-reperfusion injury is the second most common of spinal cord and has risk neurological dysfunction paralysis, which can seriously affect patient quality life. Salidroside (Sal) an active ingredient extracted from Herba Cistanche with a variety biological attributes such as antioxidant, antiapoptotic, neuroprotective activities. Moreover, Sal shown protective effect in ischemia-reperfusion liver, heart, brain, but its not been elucidated. Here, we demonstrated for first time that...
Background:The JAK/STAT signaling pathway is the main inflammatory signal transduction pathway, whether contributes pathology of SCI and targeting will alleviate needs to be addressed.Here, we explored therapeutic effect pan-JAK inhibitor tofacitinib (TOF) on secondary injury after explained underlying mechanisms.Methods: model in rat was established evaluate effects TOF treatment vivo.Histological behavioral analyses were performed at different time points SCI.In vitro, pro-inflammatory...
JOURNAL/nrgr/04.03/01300535-202408000-00034/figure1/v/2024-02-22T141052Z/r/image-tiff Spinal cord injury-induced motor dysfunction is associated with neuroinflammation. Studies have shown that the triterpenoid lupenone, a natural product found in various plants, has remarkable anti-inflammatory effect context of chronic inflammation. However, effects lupenone on acute inflammation induced by spinal injury remain unknown. In this study, we established an impact-induced mouse model injury, and...
We aimed to develop a machine-learning based predictive model identify 30-day readmission risk in Acute heart failure (AHF) patients. In this study 2232 patients hospitalized with AHF were included. The variance inflation factor value and 5-fold cross-validation used select vital clinical variables. Five machine learning algorithms good performance applied models, the discrimination ability was comprehensively evaluated by sensitivity, specificity, area under ROC curve (AUC). Prediction...
The flanker task has been used to investigate the distinct effects of "stimulus interference" (SI) and "response (RI) on performance (e.g., response times). In SI, flankers appear different in appearance from target but are associated with same response. RI, a Interference is greater for RI than SI. We investigated behavioral new kind interference—"imagery interference," which (as SI), (verbal) mental imagery. two experiments, imagery interference yielded more introduce this form hope that...
Background Traumatic spinal cord injury (SCI) causes severe motor dysfunction and persistent central neuropathic pain (Nep), which has not yet been effectively cured. Programmed cell death ligand-1 (PD-L1) is typically produced by cancer cells contributes to the immune-suppressive in tumor microenvironment. However, role of PD-L1 regulating inflammatory response Nep after SCI remains unclear. A growing amount researches have begun investigate effect on macrophages microglia recent years....
Low back pain (LBP) has been a wide public health concern worldwide. Among the pathogenic factors, intervertebral disc degeneration (IDD) one of primary contributors to LBP. IDD correlates closely with inflammatory response and oxidative stress, involving variety inflammation‐related cytokines, such as interleukin 1 beta (IL‐1 β ), which could result in local environment. Ulinastatin (UTI) is kind acidic protein extracted from human urine, inhibits release tumor necrosis factor alpha (TNF‐ α...
Chronic low back pain (CLBP) has been proved to be the dominating cause of disability in patients with lumbar degenerative diseases. Of various etiological factors, intervertebral disc degeneration (IVDD) cause. In past few decades, role and changes nerve systems, especially peripheral sensory fibers their neurotransmitters, induction progression IVDD have attracted growing concerns. The expression many neuropeptides, such as SP, NPY, CGRP, nociceptive pathways is increased during...
Lumbar intervertebral disc degeneration (IDD) has been the major contributor to low back pain (LBP). IDD is an chronic inflammation process, with activation of plentiful inflammation‐related cytokines and ECM degradation‐related enzymes. In past few years, hypertension reported correlate LBP. addition, local tissue renin‐angiotensin system (tRAS) identified in multiple tissues, including spinal cord, skin, kidney, heart, bone. Recently, tRAS also established both bovine human especially...
A persistent inflammatory response, intrinsic limitations in axonal regenerative capacity, and widespread presence of extrinsic inhibitors impede the restoration motor function after a spinal cord injury (SCI). versatile treatment platform is urgently needed to address diverse clinical manifestations SCI. Herein, we present multifunctional nanoplatform with anisotropic bimodal mesopores for effective neural circuit reconstruction The hierarchical features Janus structure consist dual...
Intervertebral disc degeneration (IDD) has been generally accepted as the major cause of low back pain (LBP), which imposes massive clinical and socioeconomic burdens. Previous studies have demonstrated that oxidative stress inflammation-induced senescence apoptosis nucleus pulposus cells (NPCs) are main cellular processes IDD. Arginase II (ARG2), an enzyme involved in a variety pathological processes, including senescence, apoptosis, stress, inflammation, shown to promote several...
Abstract Objectives Osteogenesis is coupled with angiogenesis during bone remodelling. G‐protein‐coupled receptor (GPCR) kinase 2‐interacting protein‐1 (GIT1) an important protein that participates in fracture healing by regulating angiogenesis. This study investigated whether GIT1 could affect mesenchymal stem cells (BMSCs) to secrete angiogenic factors enhance promoting and its possible mechanism. Materials methods The of mice post‐fracture was detected micro‐CT immunofluorescence....
Osteolytic bone disease is a condition of imbalanced homeostasis, characterized mainly by excessive bone-resorptive activity, which could predispose these populations, such as the old and postmenopausal women, to developing high risk skeletal fragility fracture. The nature homeostasis coordination between osteoblasts (OBs) osteoclasts (OCs). Abnormal activation (OCs) compromise constantly followed clutch osteolytic diseases, including osteoporosis, osteoarthritis, rheumatoid arthritis. Thus,...
Hyperhomocysteinemia (HHcy) is an independent risk factor for the development of atherosclerosis (AS), according to overwhelming number clinical and epidemiological studies. However, underlying pathogenic molecular mechanisms by which HHcy promotes AS remain be fully elucidated. Fatty acid binding protein 4 (FABP4) has been shown important in macrophage cholesterol trafficking. The objective present study was determine whether homocysteine (Hcy) accelerates through regulating FABP4, then...
The nonunion following a fracture is associated with severe patient morbidity and economic consequences. Currently, accumulating studies are focusing on the importance of macrophages during repair. However, details regarding process by which facilitate endochondral ossification (EO) largely unknown. In this study, we present evidence that apoptotic chondrocytes (ACs) not inert corpses awaiting removal, but positively modulate osteoinductive ability macrophages. vivo experiments revealed...
Bone homeostasis has been a dynamic equilibrium between osteoclasts (OCs) and osteoblasts (OBs). However, excessive activation of OCs could disturb the bone homeostasis. As result, effective medical interventions for patients are greatly demanding. NO/guanylate cyclase (GC)/cGMP signaling cascade previously reported to regulate metabolism, GC plays significantly critical role. Vericiguat, as novel oral soluble guanylate (sGC) stimulator, firstly in 2020 treat with heart failure....