A5102970477- Ovarian function and disorders
- Reproductive Biology and Fertility
- Menstrual Health and Disorders
- Nanoplatforms for cancer theranostics
- Histone Deacetylase Inhibitors Research
- Ginseng Biological Effects and Applications
- Ovarian cancer diagnosis and treatment
- Gut microbiota and health
- Cell Adhesion Molecules Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Protein Degradation and Inhibitors
- Sarcoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Insect Utilization and Effects
- TGF-β signaling in diseases
- Pain Mechanisms and Treatments
- Endometriosis Research and Treatment
- Angiogenesis and VEGF in Cancer
- Chemotherapy-induced organ toxicity mitigation
- Stress Responses and Cortisol
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Insect Pest Control Strategies
- Heat shock proteins research
- Neuropeptides and Animal Physiology
Nanjing Drum Tower Hospital
2019-2025
Nanjing University
2023
State Key Laboratory of Analytical Chemistry for Life Science
2023
Nanjing Medical University
2017
Morphine tolerance is a clinical challenge, and its pathogenesis closely related to the neuroinflammation mediated by Toll-like receptor 4 (TLR4). In Chinese pain clinic, lidocaine combined with morphine treat chronic pain. We found that sufficiently inhibited induced improved analgesic on basis of non-affecting threshold.CD-1 mice were utilized for tail-flick test evaluate tolerance. The microglial cell line BV-2 was investigate mechanism lidocaine. Neuroinflammation-related cytokines...
Polycystic ovary syndrome (PCOS) is an endocrine disorder and the main cause of anovulatory infertility, in which persistent activation androgen receptor (AR) due to aberrant acetylation modifications transcription a potential trigger; however, precise mechanisms AR are poorly understood. In this study, dehydroepiandrosterone- letrozole-induced rat PCOS ovaries coincided with marked increase chromatin "reader" BRD4. Further bioinformatic analysis showed that promoter contained highly...
Doxorubicin (DOX) is the classic soft tissue sarcomas (STS) first-line treatment drug, while dose-dependent myelosuppression and cardiotoxicity limit its application in clinic. This research intends to apply DOX, which also an inducer of immunogenic cell death as a part for "in situ vaccination" conjointly uses PD-1 inhibitors enhance antitumor efficacy. In order achieve sustained vaccination effect real-time monitoring distribution vivo, forming injectable hydrogel platform with function...
Abstract Objectives Osteogenesis is coupled with angiogenesis during bone remodelling. G‐protein‐coupled receptor (GPCR) kinase 2‐interacting protein‐1 (GIT1) an important protein that participates in fracture healing by regulating angiogenesis. This study investigated whether GIT1 could affect mesenchymal stem cells (BMSCs) to secrete angiogenic factors enhance promoting and its possible mechanism. Materials methods The of mice post‐fracture was detected micro‐CT immunofluorescence....
Inflammatory responses and intestinal microbiome play a crucial role in the progression of colitis-associated carcinoma (CAC). The traditional Chinese medicine maggot has been widely known owing to its clinical application anti-inflammatory function. In this study, we investigated preventive effects extract (ME) by intragastric administration prior azoxymethane (AOM) dextran sulfate sodium (DSS)-induced CAC mice. results showed that ME had superior advantages ameliorating disease activity...
Cisplatin resistance is a crucial factor affecting ovarian cancer patient’s survival rate, but the primary mechanism underlying cisplatin in remains unclear, and this prevents optimal use of therapy. Maggot extract (ME) used traditional Chinese medicine for patients with comas gastric when combined other drug treatments. In study, we investigated whether ME enhances sensitivity cells to cisplatin. Two cells—A2780/CDDP SKOV3/CDDP—were treated vitro. SKOV3/CDDP that stably expressed luciferase...
Ovarian cancer is one of the most lethal gynecological malignancies, because metastatic dissemination with poor late clinical therapy. Maggots have been used in traditional Chinese medicine, where they are also known as ‘Wu Gu Chong’. Previous studies indicated that maggot extract (ME) was beneficial for treatment gastric when combined other drugs, but effect on anti-ovarian and underlying mechanism remains unclear. The aim this study to investigate effects ME suppressing proliferation...
Background: Androgens play effective roles in abirritation and anti-inflammation by inhibiting the transmission of pain signals to brain, but not clear primary dysmenorrhea.Methods: Serum sex hormones from 194 female patients were collected analyzed association between polycystic ovary syndrome (PCOS) dysmenorrhea. Dysmenorrhea mice treated with DHEA or inhibitor, uterus acquired analyze molecular mechanisms dysmenorrhea immunohistochemical staining, chromatin immunoprecipitation (ChIP),...
Background: Persistent activation of androgen receptor (AR) due to aberrant epigenetic modifications transcription is a potential trigger polycystic ovary syndrome (PCOS); however, the precise mechanisms AR are poorly understood. Methods: PCOS rat and granulosa cell models were established investigate BRD4 (bromodomain-containing protein 4) expression regulation by Hematoxylin-eosin, Masson staining, immunohistochemical biochemical analysis. Chromatin immunoprecipitation PCR (ChIP)...