A5100456291- Ion channel regulation and function
- Pain Mechanisms and Treatments
- Advanced Chemical Sensor Technologies
- Cardiac electrophysiology and arrhythmias
- Spectroscopy and Chemometric Analyses
- Meat and Animal Product Quality
- Neuroinflammation and Neurodegeneration Mechanisms
- Medical Imaging and Analysis
- Neuropeptides and Animal Physiology
- Ion Transport and Channel Regulation
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Dental Radiography and Imaging
- Environmental Sustainability in Business
- thermodynamics and calorimetric analyses
- Skin and Cellular Biology Research
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Bone health and osteoporosis research
- Lung Cancer Research Studies
- Trace Elements in Health
- Angiogenesis and VEGF in Cancer
- Corporate Social Responsibility Reporting
- Pharmacological Receptor Mechanisms and Effects
China Pharmaceutical University
2014-2025
Simcere Pharmaceutical (China)
2023-2025
Peking University
2008-2024
Peking University Third Hospital
2023-2024
Bengbu Medical College
2024
China University of Mining and Technology
2024
Sir Run Run Shaw Hospital
2022
Zhejiang University
2022
Nanjing Medical University
2017-2019
Kangda College of Nanjing Medical University
2019
KCNJ2/Kir2.1, a member of the classical inwardly rectifying potassium channel family, is commonly expressed in wide range tissues and cell types. Previous studies indicated that Kir2.1 may be associated with SCLC multidrug resistance (MDR). However, whether can regulate MDR its underlying mechanisms remain poorly understood SCLC.KCNJ2/Kir2.1 expression was examined from fifty-two cases by immunohistochemistry. Overexpression or knockdown KCNJ2/Kir21 performed multidrug-resistant lines (H69AR...
Long-term use of morphine induces analgesic tolerance, which limits its clinical efficacy. Evidence indicated morphine-evoked neuroinflammation mediated by toll-like receptor 4 (TLR4) - NOD-like protein 3 (NLRP3) inflammasome was important for tolerance. In our study, we investigated whether other existing alternative pathways caused morphine-induced activation TLR4 in microglia. We focused on heat shock 70 (HSP70), a damage-associated molecular pattern (DAMP), released from various cells...
Radiation therapy, a fundamental treatment for tumors, is often accompanied by radiation-induced skin injury (RISI). Excessive production of reactive oxygen species (ROS) and subsequent inflammation are two key factors in RISI development that will cause affect radiotherapy. Herein, the co-assembled binary polyphenol natural products inspired dual-functional cascade microneedle system prevention RISI. Specifically, epigallocatechin gallate (EGCG) curcumin (CUR) were into nanoparticles (CEPG)...
Morphine tolerance is a clinical challenge, and its pathogenesis closely related to the neuroinflammation mediated by Toll-like receptor 4 (TLR4). In Chinese pain clinic, lidocaine combined with morphine treat chronic pain. We found that sufficiently inhibited induced improved analgesic on basis of non-affecting threshold.CD-1 mice were utilized for tail-flick test evaluate tolerance. The microglial cell line BV-2 was investigate mechanism lidocaine. Neuroinflammation-related cytokines...
Abstract The development of opioid-induced analgesic tolerance is a clinical challenge in long-term use for managing chronic pain. mechanisms morphine are poorly understood. Mitochondria-derived reactive oxygen species (ROS) crucial signal inducing and Chronic administration leads to robust ROS production accumulation damaged mitochondria, which immediately removed by mitophagy. Here, we show that inhibits mitochondria damage-induced PTEN-induced putative kinase 1 (PINK1) neurons. It...
Bifunctional agents that simultaneously antagonize and degrade various AR proteins more effectively block the signaling pathway, offering a promising strategy for treatment of mCRPC patients. Herein, we report discovery development series small-molecule degraders with 3,8-diazabicyclo[3.2.1]octan scaffold. The optimal compound 20i exhibited potent antagonistic degrading activities, overcoming multiple resistance mechanisms showing significant antiproliferative effects against...
Abstract In order to better understand the impact of green technology mergers and acquisitions (GTMA) on sustainable development, difference‐in‐differences model is applied investigate direct underlying mechanisms GTMA environment, society, governance (ESG) in China. Additionally, we established a two‐dimensional framework “market versus government” analyze heterogeneity. The results show that: (1) positively aligned with greater ESG performance, indicating that an effective way enhance...
Previous study has demonstrated that superoxide and the related products are involved in mediating effect of low K intake on renal secretion ROMK channel activity cortical collecting duct (CCD). This investigated role gp91(phox)-containing NADPH oxidase (NOXII) excretion gp91(-/-) mice. depletion increased levels, phosphorylation c-Jun, expression c-Src, tyrosine cortex outer medulla wild-type (WT) In contrast, tempol treatment WT mice abolished whereas deletion gp91 significantly attenuated...
Background . Very few studies have been conducted to compare carbon dioxide laser microsurgery (CO2-LS) with low-temperature plasma radiofrequency ablation (LTP-RFA) in treating T1a glottic cancer. Therefore, we this study the efficacy of CO2-LS and LTP-RFA define a superior therapeutic modality for Methods Patients (n=131) cancer were recruited between January 2010 September 2014. The included patients randomly assigned either receive (n=65) or (n=66). We following multidimensional vocal...
We used the patch-clamp technique and Western blot analysis to explore effect of PGE(2) on ROMK-like small-conductance K (SK) channels Ca(2+)-activated big-conductance (BK) in cortical collecting duct (CCD). Application 10 microM inhibited SK BK CCD. Moreover, either inhibition PKC or blocking mitogen-activated protein kinase (MAPK), P38 ERK, abolished The was completely blocked presence SC-51089, a specific EP1 receptor antagonist, mimicked by application sulprostone, an agonist for EP3...
Androgenetic alopecia (AGA) is the most prevalent form of progressive hair loss disorder in both men and women, significantly impacting their appearance overall quality life. Overactivation AR signaling pathway dermal papilla cells (DPCs) plays a crucial role development progression AGA. Considering severe systemic side effects associated with oral antagonists, idea developing topical antagonists rapid metabolic deactivation properties emerged as promising approach. Herein, through...
Morphine addiction has become a long-time, serious medical and social problem. To understand the cellular mechanisms of morphine application addiction, effects chronic treatments were examined in primary cultured human neurons. Our results show that, surprisingly, protects neurons against serum deprivation staurosporine induced cytotoxicity. downregulates proapoptotic factor Bax levels In addition, heat shock protein 70 is also involved protection. data suggest that may be beneficial to...
Purpose This study aimed to evaluate the difference in vertebral mechanical properties estimated by finite element analysis (FEA) with different computed tomography (CT) reconstruction kernels and their accuracy screening classification of osteoporosis. Methods There were 31 patients enrolled retrospectively from quantitative CT database our hospital, uniformly covering range osteoporosis normal. All subjects’ raw data reconstructed both a smooth standard convolution kernel (B40f) sharpening...
We evaluated the ability of contrast enhanced Doppler ultrasound (CEDU) to demonstrate changes in tumor vascularity during angiogenesis inhibitive therapy PC-3m human prostate carcinoma.Pieces carcinoma (Institute Urology, Beijing University, Beijing, People's Republic China) were transplanted subcutaneously into 48 male BALB/C nude mice (Center Animal Quarantine, China). Protamine (Shanghai Biochemistry Pharmaceutical Co., was injected as an inhibitor. The animals randomly divided 3 groups...
Objective: To investigate the clinical features, skeletal muscle imaging, and pathological characteristics of normokalemic periodic paralysis (NormoKPP) caused by mutation SCN4A gene p.R675Q. Methods: The data, test results a family with NormoKPP were collected in detail October 2018. previous literature was reviewed used for comparative analysis. Results: proband 28-year-old male paroxysmal weakness both lower limbs 14 years. Limb mainly manifested proximal extremities limbs, which occurred...
Near-infrared spectroscopy, which has advantages of high speed, precision, and minimal sample preparation, is a rapid, solvent-free, on-site quantitative qualitative analytical method. This study assessed the feasibility using near-infrared spectroscopy to determine prochloraz residue in orange juice. Two chemometric methods, partial least-squares discriminant analysis support vector machines, were employed create mathematical models classify three spectrum bands. The selected spectral...