A5100406328- Cardiac electrophysiology and arrhythmias
- Single-cell and spatial transcriptomics
- Ion channel regulation and function
- Acute Kidney Injury Research
- Pharmacological Effects of Natural Compounds
- Neonatal Respiratory Health Research
- Magnolia and Illicium research
- Neuroscience and Neural Engineering
- Cancer-related molecular mechanisms research
- Animal Genetics and Reproduction
- Gut microbiota and health
- MicroRNA in disease regulation
- COVID-19 and healthcare impacts
- Cancer, Lipids, and Metabolism
- Heavy Metal Exposure and Toxicity
- Neuroscience and Neuropharmacology Research
- Growth Hormone and Insulin-like Growth Factors
- S100 Proteins and Annexins
- Animal Nutrition and Physiology
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related gene regulation
- Angiogenesis and VEGF in Cancer
- Nanoparticles: synthesis and applications
Renmin Hospital of Wuhan University
2017-2025
Affiliated Hospital of Southwest Medical University
2023-2024
Southwest Medical University
2017-2024
Jiangnan University
2022-2024
Academy of Medical Sciences
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2024
Capital Medical University
2009-2023
Wuhan University
2017-2023
Northwest A&F University
2013-2023
Yichun University
2023
Abstract SARS-CoV-2 has rapidly spread across the United States, causing extensive morbidity and mortality, though histopathologic basis of severe disease cases yet to be studied in detail. Over past century, autopsy contributed significantly our understanding numerous processes, but for several reasons, reports following deaths related SARS- CoV-2 have thus far been limited globe. We report on relevant cardiopulmonary findings first series autopsies with cause death being due infection....
Since December 2019, an outbreak of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) initially emerged in Wuhan, China, and has spread worldwide now. Clinical features patients with COVID-19 have been described. However, risk factors leading to in-hospital deterioration poor prognosis not well identified. In this retrospective, single-center cohort study, 1190 adult inpatients (≥ 18 years old) laboratory-confirmed determined...
Aims: Mitochondrion is considered as the major source of intracellular reactive oxygen species (ROS). H2S has been reported to be an antioxidant, but its mechanism remains largely elusive. P66Shc upstream activator mitochondrial redox signaling. The aim this study was explore whether antioxidant effect mediated by p66Shc. Results: Application exogenous with donor, NaHS, or overexpression generating enzyme, cystathionine β-synthase, induced sulfhydration p66Shc, inhibited phosphorylation...
Abstract Background There are many diseases in poultry, of which caused by poor immune function. It is not clear how cytokines and various cell functions change with age modern broilers. The purpose this study was to explore the patterns development immunity broiler chickens cage. Results results showed that there were 3 chickens. first pattern Down-Up. Cytokines some indicators decreased then increased, lowest levels basically occurred from d 6 13. second Up-Down, 30 34, highest...
Abstract The CACNA1C (calcium voltage-gated channel subunit alpha 1 C) gene that encodes the Ca V 1.2 is a prominent risk for neuropsychiatric and neurodegenerative disorders with cognitive social impairments like schizophrenia, bipolar disorders, depression autistic spectrum (ASD). We have shown previously mice exon 33 deleted from (Ca 1.2-exon −/− ) displayed increased current density single open probability in cardiomyocytes, were prone to develop arrhythmia. As 2+ entry through channels...
Ulcerative colitis is a chronic inflammatory bowel disorder with cellular heterogeneity. To understand the composition and spatial changes of ulcerative ecosystem, here we use imaging mass cytometry single-cell RNA sequencing to depict landscape human colon ecosystem. We find tissue topological featured macrophage disappearance reaction in region, occurring only for tissue-resident macrophages. Reactive oxygen species levels are higher but reactive scavenging enzyme SOD2 barely detected...
Native smooth muscle L-type Ca(v)1.2 calcium channels have been shown to support a fraction of Ca(2+) currents with window current that is close resting potential. The are also more susceptible inhibition by dihydropyridines (DHPs) than the cardiac channels. It was hypothesized exhibiting hyperpolarized shift in steady-state inactivation would contribute larger DHP, addition structural differences generated alternative splicing modulate DHP sensitivities. In addition, it has modulates...
This study was conducted to investigate the effects of dietary arginine (Arg) supplementation on inflammatory response and gut microbiota broiler chickens subjected Salmonella enterica serovar Typhimurium. One hundred forty 1-day-old Arbor Acres male birds were randomly assigned a 2 × factorial arrangement including diet treatment (with or without 0.3% Arg supplementation) immunological stress S. typhimurium challenge). Samples obtained at 7 D after infection (day 23). Results showed that...
Abstract Atherosclerotic cardiovascular disease remains the leading cause of morbidity and mortality in industrialized societies. The lack metabolite biomarkers has impeded clinical diagnosis atherosclerosis so far. In this study, stable patients ( n =16) age‐ sex‐matched non‐atherosclerosis healthy subjects =28) were recruited from local community (Harbin, P. R. China). plasma was collected each study subject subjected to metabolomics analysis by GC/MS. Pattern recognition analyses...
In this study, we evaluated the protective effects of naringenin on aging mice induced by d-galactose (d-gal). Open field test and Morris water maze were performed to evaluate effect behavioral dysfunction. Hematoxylin-eosin staining, TUNEL Nissl staining used estimate neurological deficits. Furthermore, markedly activated PI3K/Akt signaling, eventually promoted nuclear translocation factor-erythroid 2-related factor 2, expression heme oxygenase 1 NAD(P)H-quinone oxidoreductase 1. Superoxide...
This study aimed to compare the immune function and gut microbiota between double-layer caged litter floor pen-raised broiler chickens. Eighty meaty male chicks were selected divided into cage group group, with 20 replicates in each group. The broilers raised same chicken house. rearing density of two systems was same. sampled on days 13 34. results showed that compared had worse growth performance (23.24% increase feed conversion ratio) early stage; better slaughter at day 42; stronger...
Soil salinization is one of the main factors contributing to land degradation, affecting ecological equilibrium, environmental health, and sustainable development agriculture. Due spatial temporal heterogeneity soil properties conditions in a large-scale region, monitoring accuracy can be challenging. This study investigated whether classification diverse crop types on time series improve prediction regional salinity levels. Specifically, we evaluated changes salt content (SSC) under...
Abstract Purpose: The purpose is to characterize alterations of the annexin I gene, its mRNA, and protein expression in esophageal squamous cell carcinoma. Experimental Design: Fifty-six cases carcinoma were analyzed using four microsatellite markers flanking gene (9q11-q21) identify loss heterozygosity. In addition, we performed (a) single-strand conformation polymorphism DNA sequencing along entire promoter sequence coding region mutations, (b) real-time quantitative reverse...
The aim of this study was to investigate the expression β-catenin, axin, cyclin D1 and c-myc, their correlation with various clinicopathological factors breast carcinoma. Using immunohistochemistry, c-myc proteins detected in 168 carcinomas 40 normal tissue samples, as well 72 intraductal proliferative lesions. Correlations among these were subsequently analyzed. Gene mutations β-catenin (exon 3) 44 cases carcinoma analyzed using polymerase chain reaction (PCR) followed by direct sequencing....
Pulmonary hypertension (PH) develops in 30-70% of chronic obstructive pulmonary disease patients and increases morbidity mortality. The present study aimed to investigate the regulation small ubiquitin‑related modifier‑1 (SUMO‑1) expression response hypoxia. experiments were carried out vitro rat arterial smooth muscle cells (PASMCs) vivo using a hypoxic PH (HPH) model. A significant increase SUMO‑1 mRNA protein levels was observed following stimulation vitro. is known interact with various...
Abstract The study of pulmonary samples from individuals who have died as a direct result COVID-19 infection is vital to our understanding the pathogenesis this disease. Histopathologic studies lung tissue autopsy patients with specific mortality are only just emerging. All existing reports relied on traditional 2-dimensional slide-based histological methods for specimen preparation. However, emerging high-resolution, massively multiscale imaging microstructure using fluorescence labeling...