A5100404865- Adipose Tissue and Metabolism
- Alzheimer's disease research and treatments
- Metabolomics and Mass Spectrometry Studies
- Sirtuins and Resveratrol in Medicine
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Genomics, phytochemicals, and oxidative stress
- Neuroinflammation and Neurodegeneration Mechanisms
- Microbial Metabolic Engineering and Bioproduction
- Biochemical effects in animals
- Receptor Mechanisms and Signaling
- Antioxidants, Aging, Portulaca oleracea
- Fungal Biology and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Plant Toxicity and Pharmacological Properties
- Microbial Natural Products and Biosynthesis
- Bioactive natural compounds
- Sesquiterpenes and Asteraceae Studies
- Advanced Drug Delivery Systems
- RNA Research and Splicing
- Alkaloids: synthesis and pharmacology
- Menopause: Health Impacts and Treatments
- Renin-Angiotensin System Studies
- PARP inhibition in cancer therapy
- Plant-derived Lignans Synthesis and Bioactivity
Heilongjiang University of Chinese Medicine
2015-2025
Nantong University
2024
University of Dundee
2024
Hangzhou Children's Hospital
2024
MRC Protein Phosphorylation and Ubiquitylation Unit
2024
Wuxi Taihu Hospital
2023
Hainan Medical University
2023
University of Toyama
2014-2022
Weatherford College
2022
Capital Medical University
2020
Pain, a critical component of host defense, is one hallmark the inflammatory response. We therefore hypothesized that pain might be exacerbated by proinflammatory chemokines. To test this hypothesis, CCR1 was cotransfected into human embryonic kidney (HEK)293 cells together with transient receptor potential vanilloid 1 (TRPV1), cation channel required for certain types thermal hyperalgesia. In these cells, capsaicin and anandamide induced Ca 2+ influx mediated TRPV1. When CCR1:TRPV1/HEK293...
In this study, we evaluated the protective effects of naringenin on aging mice induced by d-galactose (d-gal). Open field test and Morris water maze were performed to evaluate effect behavioral dysfunction. Hematoxylin-eosin staining, TUNEL Nissl staining used estimate neurological deficits. Furthermore, markedly activated PI3K/Akt signaling, eventually promoted nuclear translocation factor-erythroid 2-related factor 2, expression heme oxygenase 1 NAD(P)H-quinone oxidoreductase 1. Superoxide...
The aim of the present study was to investigate neuroprotective effects naringin on memory impairment hydrocortisone mice, and elucidate potential underlying molecular mechanisms. In study, a model constructed. Novel object recognition, Morris water maze step‑down tests were performed in order assess learning abilities mice. Hematoxylin eosin staining used observe pathological changes hippocampus hypothalamus. Transmission electron microscopy ultrastructural hippocampus. Immunohistochemistry...
To study the ameliorative effect of Eucommiae Cortex extract on spatial learning disabilities in APP/PS1 double-transgenic mice and explore its relationship with estrogen receptor β(ERβ)/c-Jun N-terminal kinase(JNK) signaling pathway, sixty 3-month-old male were randomly divided into a model group, an anti-brain failure capsule group(0.585 g·kg~(-1)), donepezil hydrochloride group(0.65 mg·kg~(-1)), group(1.3 15 C57BL/6 same genetic background set as WT control group. The memory ability was...
Abstract High glucose (HG)‐induced cardiomyocytes (CMs) injury is a leading cause of diabetic cardiomyopathy with little treatment options. Irisin, new myokine, which cleaved from its precursor fibronectin type III domain‐containing protein 5 (FNDC5), has aroused great attention as an essential cardioprotective factor and metabolism regulator but was known on yet. Here, we aim to clarify the role irisin in HG‐induced CMs injury. Neonatal Sprague–Dawley rat were cultured normal or HG medium...
The inducible NO synthase gene (iNOS) plays a role in number of chronic and acute conditions, including septic shock contact hypersensitivity autoimmune diseases, such as rheumatoid arthritis, gastrointestinal disorders, myocardial ischemia. iNOS is primarily under transcriptional control induced variety conditions. ability to monitor quantify expression vivo may facilitate better understanding the different diseases. In this study, we describe transgenic mouse (iNos-luc) which luciferase...
Aging is a complex process that accompanied by neurological damage.
Zhimu-Huangbo (ZB) herb pair is a common prescription drug used by physicians of all dynasties, and has significant neuroprotective effect, such as the ZB can significantly promote neuronal cell regeneration, repair damage, improve cognitive disorders. However, its ingredients are urgently needed to be identified mechanisms remained unclear. Using ultra performance liquid chromatography-quadrupole-time flight-mass spectrometry (UPLC-Q-TOF-MS), study mechanism extract (ZBE) investigated,...
A new diketopiperazine alkaloid named spirotryprostatin K (1), and five known alkaloids, spiro[5H,10H-dipyrrolo[1,2-a:1',2'-d]pyrazine-2(3H),2'-[2H]-indole]-3',5,10(1'H) trione (2), 6-methoxyspirotryprostatin B (3), pseurotin (4), N-β-acetyltryptamine (5), lumichrome (6) were isolated from the endophytic fungus Aspergillus fumigatus. The structure absolute configuration of established by extensive spectroscopic analyses, acid hydrolysis ECD calculations. Pseurotin exhibited indirect...
Progressive accumulation of amyloid-β (Aβ) is a pathological trait Alzheimer's disease (AD). Amyloid-β increases free radical production in neuronal cells, leading to cell death. Hormone replacement therapy can reduce the incidence AD, and oestrogen significantly improves clinical signs patients with AD. However, long-term use causes variety diseases. Phytoestrogens have been reported bind activate receptors mammals humans produce oestrogen-like or anti-oestrogen-like effects. Kaempferol...
Abstract Nuclear factor (NF)κB is a transcription that controls immune and inflammatory signaling pathways. In skeletal muscle, NFκB has been implicated in the regulation of metabolic processes tissue mass, yet its affects on mitochondrial function this are unclear. To investigate role relationship with muscle mass across life span, we study mouse model muscle-specific suppression (muscle-specific IκBα super-repressor [MISR] mice). wild-type mice, there was natural decline aging accompanied...
BACKGROUND The aim of this study was to investigate the protective mechanism neurovascular unit Buyang Huanwu decoction (BYHWD) in an Alzheimer's disease (AD) cell model via RAGE/LRP1 pathway and find a reliable target for treatment. MATERIAL AND METHODS Rat brain microvessel endothelial cells (BMECs) were cultured 10% FBS 1% penicillin/streptomycin. AD established by administration 24 μmol/L amyloid-ß peptides 25~35. Different concentrations BYHWD (0.1 mg/mL, 1 10 mg/mL) added as drug...
The renin-angiotensin system is a highly complex enzymatic consisting of multiple peptide hormones, enzymes, and receptors. Here, an assay to simultaneously quantify eight angiotensin peptides bradykinin in human serum was developed validated, using ultra high performance liquid chromatography coupled with tandem mass spectrometry. A pre-concentration method Sephadex LH-20 gel solid-phase extraction first applied for analysis from sample. triple quadrupole spectrometer operated the positive...
To elucidate the potential mechanisms of QFY for treatment Alzheimer's Disease (AD), and explore effective substances QFY.UPLC-LTQ-Orbitrap-MS was used to identify chemical constituents serum samples cerebrospinal fluid rats after administration. Network pharmacology predict targets pathways against AD. The AD mice model established by subcutaneous injection D-gal 8 consecutive weeks. New object recognition (NOR) Morris water maze test (MWM) were evaluate learning memory abilities mice....
The Wujia Shenghua capsule (WSC) is derived from Sheng-Hua-Tang, a well-known traditional Chinese medicine compound prescription that has been widely applied during the postpartum period in communities for number of years. aim present study was to investigate effect WSC on uterine bleeding following medically‑induced incomplete abortion rats early pregnancy. Incomplete abortions were induced Wistar pregnancy using mifepristone combined with misoprostol. effects treatment investigated terms...
Phytochemistry investigation on Pteris ensiformis led to the isolation of a new ent-kaurane diterpenoid, ent-kaurane-6β,16α-diol-3-one (1), along with five known diterpenoids (2–6) and three sesquiterpenes (7–9). Their structures were established by means spectroscopic methods. The ethanol extract isolated compounds (1–9) evaluated for their antitumor activity against cancer cell lines.