A5019209698- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Retinal Diseases and Treatments
- Autophagy in Disease and Therapy
- Vaccine Coverage and Hesitancy
- Mesenchymal stem cell research
- Retinal Development and Disorders
- Ferroptosis and cancer prognosis
- Adipokines, Inflammation, and Metabolic Diseases
- Animal Virus Infections Studies
- Connexins and lens biology
- RNA modifications and cancer
- Adipose Tissue and Metabolism
- Vascular Malformations Diagnosis and Treatment
- COVID-19 Impact on Reproduction
- Electrospun Nanofibers in Biomedical Applications
- Cancer, Hypoxia, and Metabolism
- Vascular Tumors and Angiosarcomas
- Retinal Imaging and Analysis
- Intensive Care Unit Cognitive Disorders
- Glaucoma and retinal disorders
- Anesthesia and Neurotoxicity Research
- Metabolism, Diabetes, and Cancer
- Hydrogen's biological and therapeutic effects
Sichuan University
2013-2025
State Key Laboratory of Biotherapy
2013-2025
University of Hong Kong
2019-2024
Beijing University of Chinese Medicine
2020-2024
Chinese University of Hong Kong
2019-2024
Peking University People's Hospital
2018-2024
Peking University
2018-2024
Wenzhou Hospital of Traditional Chinese Medicine
2023-2024
Tsinghua–Berkeley Shenzhen Institute
2022
Shenzhen University
2018-2021
The response of AMP-activated protein kinase (AMPK) to oxidative stress has been recently reported but the downstream signals this are largely unknown. Meanwhile, upstream events for activation nuclear factor erythroid-2-related factor-2 (Nrf2), a critical transcriptional activator antioxidative responses, remain unclear. In present study, we investigated relationship between AMPK and Nrf2 signal pathways in lipopolysaccharide (LPS)-triggered inflammatory system, which berberine (BBR), known...
Abstract Retinal pigment epithelium (RPE) degeneration plays an important role in a group of retinal disorders such as (RD) and age-related macular (AMD). The mechanism RPE cell death is not yet fully elucidated. Ferroptosis, novel regulated pathway, participates cancer several neurodegenerative diseases. Glutathione peroxidase 4 (GPx-4) ferroptosis suppressor protein 1 (FSP1) have been proposed to be two main regulators these diseases; yet, their roles remain elusive. Here, we report that...
Abstract Bone marrow‐derived mesenchymal stem cells (BM‐MSCs) have been demonstrated as an ideal autologous source for cell‐based therapy myocardial infarction (MI). However, poor viability of donor after transplantation limits their therapeutic efficiency, whereas the underlying mechanism is still poorly understood. Autophagy, a highly conserved process cellular degradation, required maintaining homeostasis and normal function. Here, we investigated potential role autophagy on apoptosis in...
ABSTRACT Time‐restricted feeding (TRF) is a distinct regimen of intermittent fasting advocated for health improving. Although nighttime TRF (NRF) in rodents analogous to daytime (DRF) humans and has benefits, the effects DRF on rodent's remain uncertain. The adverse are primarily attributed its implementation‐induced temporal shift expression circadian rhythm‐related genes. However, studies also demonstrate health–beneficial effect restricted itself metabolic homeostasis, particularly...
Age-related macular degeneration (AMD) is a sight-threatening disease with limited treatment options. We investigated whether amyloid β1-40 (Aβ1-40) could cause pyroptosis and evaluated the effects of Lycium barbarum polysaccharides (LBP) on Aβ1-40 oligomers-induced retinal pigment epithelium 19 (ARPE-19) damage, which an in vitro AMD model. oligomers verified by Western blot were added to ARPE-19 cells or without 24 h LBP treatment. significantly decreased cell viability obvious...
Abstract High glucose (HG)‐induced cardiomyocytes (CMs) injury is a leading cause of diabetic cardiomyopathy with little treatment options. Irisin, new myokine, which cleaved from its precursor fibronectin type III domain‐containing protein 5 (FNDC5), has aroused great attention as an essential cardioprotective factor and metabolism regulator but was known on yet. Here, we aim to clarify the role irisin in HG‐induced CMs injury. Neonatal Sprague–Dawley rat were cultured normal or HG medium...
Treatment with bone marrow mesenchymal stem cells (BM-MSCs) has been demonstrated to be an excellent cellular-based therapeutic strategy for treating myocardial infarction (MI). However, most of the patients suffering MI are elderly. Hypoxic conditions can cause apoptosis BM-MSCs, and this type is more prevalent in aged BM-MSCs. Decreased autophagy one mechanisms underlying aging. The aim study uncover whether increased hypoxic injury BM-MSCs due reducing diminishes tolerance hypoxia
Genome-wide association studies have linked variants of fat mass and obesity-associated protein (FTO) to obesity. However, the molecular function FTO remains unclear. In this study, we sought investigate potential effects in modulating cholesterol deposition macrophage foam cells, as well whether exerts antiatherosclerotic properties apolipoprotein E-deficient mice.We transfected RAW264.7 cells with plasmids encoding a wild-type or mutant gene (I367F). The upregulation markedly attenuated...
To investigate the potential effect of IP7 on autophagy and apoptosis bone marrow mesenchymal stem cells (BM-MSCs) caused by hypoxia. BM-MSCs isolated from adult male C57BL/6 mice were exposed to normoxic condition hypoxic stress for 6 h, 12 24 respectively. Then, flow cytometry detected characteristics BM-MSCs. Furthermore, N6-(p-nitrobenzyl) purine (TNP) was administrated inhibit inositol pyrophosphates (IP7). TUNEL assay determined in with Meanwhile, RFP-GFP-LC3 plasmid transfection...
Protein kinase Cβ (PKCβ) is a serine-threonine associated with obesity and diabetic complications; its activation contributes to weight gain, deletion of gene results in resistance genetic- diet-induced obesity. Fat mass obesity-associated (FTO) protein recently identified RNA demethylase, overexpression mice leads increased body as well fat mass. Although sharing some features anabolism regulation, PKCβ FTO have not been investigated together; therefore, their relationship has established....
Glaucoma and visual pathway degeneration: is the leading cause of irreversible blindness worldwide, which leads to a progressive loss vision. can be classified into two types: primary open-angle glaucoma closed-angle glaucoma. Primary caused by blockage trabecular meshwork, this results in elevation intraocular pressure (IOP), retinal ganglion cell (RGC) death. However, many patients have normal IOP; known as normal-tension Nevertheless, excitotoxic damage oxidative stress also lead RGC...
Purpose: We evaluated the effects of lentivirus-mediated exoenzyme C3 transferase (C3) expression on cultured primary human trabecular meshwork (HTM) cells in vitro, and rat intraocular pressure (IOP). Methods: HTM were treated with lentivirus vectors expressing either green fluorescent protein (GFP) only (LV-GFP) or GFP together (LV-C3-GFP). Changes cell morphology actin stress fibers assessed. The also injected into anterior chamber rats, was visualized by a Micron III Retinal Imaging...