A5085243399- Genetics, Aging, and Longevity in Model Organisms
- Pharmacogenetics and Drug Metabolism
- Meat and Animal Product Quality
- Anaerobic Digestion and Biogas Production
- Protein Hydrolysis and Bioactive Peptides
- Wastewater Treatment and Nitrogen Removal
- Spaceflight effects on biology
- Insect Utilization and Effects
- Enzyme Catalysis and Immobilization
- RNA modifications and cancer
- Circadian rhythm and melatonin
- Connexins and lens biology
- Environmental Toxicology and Ecotoxicology
- Marine Biology and Environmental Chemistry
- Food Industry and Aquatic Biology
- Bacteriophages and microbial interactions
- Microbial Metabolic Engineering and Bioproduction
- RNA Research and Splicing
- Aldose Reductase and Taurine
- Retinal Diseases and Treatments
- Effects and risks of endocrine disrupting chemicals
- Click Chemistry and Applications
- Occupational and environmental lung diseases
- Aquatic Ecosystems and Biodiversity
- Chromium effects and bioremediation
State Key Laboratory of Pollution Control and Resource Reuse
2020-2024
Tongji University
2020-2024
Huainan Normal University
2009-2024
Yunnan Institute of Tropical Crops
2023
Anhui University of Science and Technology
2013-2021
Hefei National Center for Physical Sciences at Nanoscale
2020
University of Science and Technology of China
2017-2020
Jiangsu University
2020
National Institutes of Health
2006-2019
National Institute on Drug Abuse
2019
A novel zerovalent iron (ZVI) technique to simultaneously improve the production of medium-chain fatty acids (MCFAs) from waste activated sludge (WAS) and enhance WAS degradation during anaerobic fermentation was proposed in this study. Experimental results showed that selectivity MCFAs were effectively promoted when ZVI added at 1–20 g/L. The maximum 15.4 g COD (Chemical Oxygen Demand)/L 71.7% both achieved 20 g/L ZVI, being 5.3 4.8 times without (2.9 COD/L 14.9%). Additionally, also...
Bisphenol A (BPA) is putatively regarded as an environmental neurotoxicant found in everyday plastic products and materials, however, the possible neurobehavioral adverse consequences molecular mechanisms animals have not been clearly characterized. The nematode Caenorhabditis elegans has become a promising animal model for neurotoxicological researches. To investigate dose-effect relationships of BPA-induced neurotoxicity effects, locomotion behavior developmental parameters were determined...
P450 fatty acid decarboxylases represented by the unusual CYP152 peroxygenase family member OleTJE have been receiving great attention recently since these enzymes are able to catalyze simple and direct production of 1-alkenes for potential applications in biofuels biomaterials. To gain more mechanistic insights, broader substrate spectra, improved decarboxylative activities, it is demanded discover investigate decarboxylases. Here, we describe first time expression, purification, vitro...
ABSTRACT Bacillus anthracis spores, the etiological agents of anthrax, possess a loosely fitting outer layer called exosporium that is composed basal and an external hairlike nap. The filaments nap are formed by trimers collagenlike glycoprotein BclA. Multiple pentasaccharide trisaccharide side chains O linked to nonreducing terminal residue chain unusual sugar anthrose. A plausible biosynthetic pathway for anthrose biosynthesis has been proposed, antABCD operon encoding four putative...
Abstract Mitomycin c (MMC), a quinone-containing anticancer drug, is known to redox cycle and generate reactive oxygen species. A key enzyme mediating MMC cycling cytochrome P450 reductase, microsomal NADPH-dependent flavoenzyme. In the present studies, Chinese hamster ovary (CHO) cells overexpressing this (CHO-OR cells) corresponding control (CHO-WT were used investigate role of reductase in actions MMC. lysates from both cell types, was found H2O2; activity greater CHO-OR (Vmax = 1.2 ± 0.1...
Hepatotoxin microcystin-LR (MC-LR) can induce apoptosis in a variety of cells. However, the underlying pathways MC-LR-induced have not been well elucidated yet. To find out roles signaling response to MC-LR, germ cell corpses were scored Caenorhabditis elegans N2 wild type and strains carrying mutated alleles homologous their mammalian counterparts. We found that exposure MC-LR at 1.0 μg/L significantly increased germline N2. Germline was absent all doses ced-3 ced-4 loss-of-function...
Prodynorphin-derived peptides elicit various pathological effects including neurological dysfunction and cell death. These actions are reduced by N-methyl-d-aspartate receptor (NMDAR) but not opioid antagonists suggesting NMDAR-mediation. Here, we show that a conserved epitope (KVNSEEEEEDA) of the NR1 subunit NMDAR binds dynorphin (DYNp) noncovalently. Synthetic containing this form stable complexes with DYNp prevent potentiation NMDAR-gated currents produced DYNp. They attenuate DYNp-evoked...
This study aimed to investigate the effects of storage time on sensory and biochemical properties as well bacterial community composition vacuum-packaged crab meat shucked by high pressure processing (300 MPa/20 min/25°C) stored at 4°C for 8 days. The aerobic plate count (APC), total volatile base nitrogen (TVBN), histamine content reached 5.71 log CFU/g, 24.50, 0.99 mg/100 g, respectively, 8th day, which was below reference limit. However, limit recommended be 6 days evaluation. Among...
Asymmetric Nω,Nω-dimethyl-l-arginine (ADMA) is an endogenously produced inhibitor of human nitric oxide synthase and emerging biomarker for cardiovascular disease. Concentrations ADMA are controlled by two isoforms its catabolic enzyme dimethylarginine dimethylaminohydrolase (DDAH), the dysregulation which has been studied as a mediating factor endothelial dysfunction. A two-part, click-chemistry mediated activity-based probe, N-but-3-ynyl-2-chloroacetamidine, shown to label myc-tagged...
Our data provide the direct<italic>in vivo</italic>evidence to indicate molecular signalling mechanism of endosulfan-induced apoptosis.
Purpose: We evaluated the effects of lentivirus-mediated exoenzyme C3 transferase (C3) expression on cultured primary human trabecular meshwork (HTM) cells in vitro, and rat intraocular pressure (IOP). Methods: HTM were treated with lentivirus vectors expressing either green fluorescent protein (GFP) only (LV-GFP) or GFP together (LV-C3-GFP). Changes cell morphology actin stress fibers assessed. The also injected into anterior chamber rats, was visualized by a Micron III Retinal Imaging...
Bisphenol A can trigger germline apoptosis<italic>via</italic>three signaling pathways including DNA damage response (DDR) pathway, mitogen-activated protein kinase (MAPK) cascades and insulin-like growth factor-1 (IGF-1) network in<italic>Caenorhabditis elegans</italic>.
Modification of RNAs, particularly at the terminals, is critical for various essential cell processes; example, uridylation implicated in tumorigenesis, proliferation, stem maintenance, and immune defense against viruses retrotransposons. Ribosomal RNAs can be regulated by antisense ribosomal siRNAs (risiRNAs), which downregulate pre-rRNAs through nuclear RNAi pathway Caenorhabditis elegans. However, biogenesis regulation risiRNAs remain obscure. Previously, we showed that 26S rRNAs are...