A5100762838- Atherosclerosis and Cardiovascular Diseases
- S100 Proteins and Annexins
- Lipid metabolism and disorders
- Blood properties and coagulation
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Erythrocyte Function and Pathophysiology
- Hydrogen's biological and therapeutic effects
- Cancer Cells and Metastasis
- Chemokine receptors and signaling
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Microplastics and Plastic Pollution
- Biomarkers in Disease Mechanisms
- Hippo pathway signaling and YAP/TAZ
- HIV, Drug Use, Sexual Risk
- Wnt/β-catenin signaling in development and cancer
- Traditional Chinese Medicine Analysis
- Cellular Mechanics and Interactions
- Blood donation and transfusion practices
- Cytokine Signaling Pathways and Interactions
- Total Knee Arthroplasty Outcomes
- Congenital Diaphragmatic Hernia Studies
- Medicinal Plants and Bioactive Compounds
Guangzhou Blood Center
2014-2024
Affiliated Hospital of Southwest Medical University
2019-2024
First Affiliated Hospital of Sichuan Medical University
2023
Southwest Medical University
2019-2022
Xinjiang Medical University
2017-2020
West China Hospital of Sichuan University
2007-2017
Sichuan University
2007-2017
West China Medical Center of Sichuan University
2005-2008
Sun Yat-sen University
2005
Epithelial-mesenchymal transition (EMT) is a biological process that associated with cancer metastasis and invasion. In cancer, EMT promotes cell motility, invasion distant metastasis. Interleukin (IL)-8 highly expressed in tumors may induce EMT. The IL-8/IL-8R axis has vital role carcinoma, which regulated by several signaling pathways, including the transforming growth factor β-spleen tyrosine kinase/Src-AKT/extracellular signal-regulated kinase, p38/Jun N-terminal kinase-activating...
Fractalkine (FKN) is a cytokine which plays an important role in atherosclerosis and other inflammatory diseases. Studies have shown that FKN induces integrin-independent leukocyte adhesion to primary endothelial cells under physiological flow conditions. Further, increased expression of has been demonstrated atherosclerotic lesions induced by low shear stress. However, the signal transduction mechanisms involved stress-induced upregulation are not well characterized. In this study, EA.hy926...
Atherosclerosis is a significant cause of mortality and morbidity. Studies suggest that the chemokine receptor CX3CR1 plays critical role in atherogenesis. Shear stress an important mechanical force affects blood vessel function. In this study, we investigated effect shear on expression vascular endothelial cells (VECs). First, were exposed to different then mRNA protein measured by quantitative RT-PCR western blot analysis, respectively. gene silencing was used analyze molecular mechanisms...
Low shear stress (LSS) has been reported to induce atherosclerosis. However, the molecular mechanisms underlying inflammation induced by LSS are still poorly understood. The objective of our study is comprehensive identification circuitry involved in low stress-induced human umbilical vein endothelial cells (HUVECs) through protein profiling and cell function experiment. In this study, Western blotting analyses revealed a significant increase expression CX3CR1, nucleusP65, intercellular...
Shear stress is thought to be important in maintaining vascular homeostasis and regulating remodeling. The authors have previously shown that low shear increases interleukin (IL)-8 gene expression endothelial cells. However, the detailed events contribute regulation of this remain identified. In study, examined whether stress-induced IL-8 mRNA cells mechanotransduced by integrins cytoskeleton. Exposure (4.2 dyne/cm(2)) rapidly increased mRNA. induced was inhibited GRGDNP, which blocked...
Micro- and nanoplastics have recently been detected in human blood placentas, indicating inevitable embryonic exposure to these particles. However, their influence on embryogenesis the underlying mechanisms are still unknown. In this study, effects of polystyrene (PS-NPs) cardiac differentiation stem cells (hESCs) were evaluated. Uptake PS-NPs not only caused cellular injury, but also regulated cardiac-related KEGG pathways as revealed by RNA-sequencing. Consequently, efficiency...
Pulmonary hypertension (PH) associated with congenital heart disease is a progressive hemodynamic that can lead to increased pulmonary vascular resistance, remodeling, and even right failure death. LF3 novel inhibitor of the reporter gene activity β-catenin/TCF4 interaction in Wnt/β-catenin signal pathway. However, whether this action prevent PH development remains unclear. In study, we investigated therapeutic effect rat primary artery smooth muscle cells (PASMCs) model. We found inhibited...
Background: The occurrence and development of atherosclerosis are closely related to shear stress on the endothelial cells. However, molecular mechanisms controlling mechanical signal transduction in cells remain largely unknown. Aim Study: To obtain this goal, here, a parallel-plate flow chamber was used impose laminar (8.4 dyne/cm2 ) for 0 minute (min), 10 min, 30 60 120 min. Subjects Methods: RNA interference employed down-regulate scavenger receptor class B1 (SRB1) LY294002 performed...
Abstract Background China's significant population affected by HIV poses a substantial threat to blood transfusion safety. Despite advancements in testing techniques, residual risk of transmission persists. Accurately assessing epidemic and the is vital for monitoring supply safety evaluating effectiveness new screening tests. Methods We conducted retrospective analysis detection results among voluntary donors from 2003 2022. The study included data on HIV‐confirmed positive donors,...
Atrial fibrillation (AF) stands as a prevalent and detrimental arrhythmic disorder, characterized by intricate pathophysiological mechanisms. The availability of reliable reproducible AF models is pivotal in unraveling the underlying mechanisms this complex condition. Unfortunately, researchers are still confronted with absence consistent vitro models, hindering progress crucial area research. Human induced pluripotent stem cells derived atrial myocytes (hiPSC-AMs) were generated based on...
Studies have reported the polymorphism of human platelet antigen (HPA)-17w, -18w, -19w, -20w, and -21w. However, distribution these five antigens in Chinese Cantonese is still unknown. In this study, we designed new sequence-specific primers for HPA-19w to -21w used published HPA-17w -18w develop a polymerase chain reaction with (PCR-SSP) method simultaneously genotyping A total 820 unrelated apheresis donors Guangzhou were involved study. Among HPAs, complete a/a homozygosity was observed...