A5063495196- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- Pluripotent Stem Cells Research
- Fluoride Effects and Removal
- Chronic Kidney Disease and Diabetes
- Diatoms and Algae Research
- Electrospun Nanofibers in Biomedical Applications
- Bone and Dental Protein Studies
- Platelet Disorders and Treatments
- Plant Toxicity and Pharmacological Properties
- Immune cells in cancer
- Neuroscience and Neural Engineering
- Renal Diseases and Glomerulopathies
- Ferroptosis and cancer prognosis
- Natural product bioactivities and synthesis
- Cell Adhesion Molecules Research
- Genomics, phytochemicals, and oxidative stress
- Renal and related cancers
- Biological Activity of Diterpenoids and Biflavonoids
- Aldose Reductase and Taurine
- Botanical Research and Chemistry
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Phytoestrogen effects and research
Chiang Mai University
2015-2025
University of Glasgow
2007-2012
Stem cells have the capacity to differentiate into various lineages, and ability reliably direct stem cell fate determination would tremendous potential for basic research clinical therapy. Nanotopography provides a useful tool guiding differentiation, as features are more durable than surface chemistry can be modified in size shape suit desired application. In this paper, nanotopography is examined means guide its application described context of different subsets cells, with particular...
Podocyte injury plays a critical role in the progression of focal segmental glomerulosclerosis (FSGS). Here, it is reported that B-cell translocation gene 2 (Btg2) promotes Adriamycin (ADR)-induced FSGS via Smad3-dependent podocyte-mesenchymal transition. It found patients and animal models, Btg2 markedly upregulated by podocytes correlated with progressive renal injury. Podocyte-specific deletion protected against onset proteinuria ADR-treated mice along inhibition EMT markers such as α-SMA...
Background: Sanguisorba Officinalis L. (SO) is a well-known traditional Chinese medicine (TCM), commonly applied to treat complex diseases, such as anticancer, antibacterial, antiviral, anti-inflammatory, anti-oxidant and hemostatic effects. Especially, it has been reported exert anti-tumor effect in various human cancers. However, its pharmacological mechanism on hepatocellular carcinoma (HCC) remains unclear. Methods: In this study, network pharmacology approach was characterize the...
Mitochondria-related metabolic reprogramming plays a major role in the occurrence, development, drug resistance, and recurrence of acute myeloid leukemia (AML). However, roles mitochondria-related genes (MRGs) prognosis immune microenvironment for AML patients remain largely unknown. In this study, by least absolute shrinkage selection operator (LASSO) Cox regression analysis, 4 MRGs' (HPDL, CPT1A, IDH3A, ETFB) signature was established that demonstrated good robustness TARGET datasets. The...
Previous studies have shown that microgroove-initiated contact guidance can induce bone formation in osteoprogenitor cells (OPGs) and produce changes the cell proteome. For proteomic analysis, differential in-gel electrophoresis (DIGE) be used as a powerful diagnostic method to provide comparable data between profiles of cultured different conditions. This study focuses on response OPGs novel nanoscale pit topography with osteoinductive properties compared planar controls. Disordered...
Dental pulp tissue contains stem cells that can be isolated and used for regenerative medicine in tooth restoration or autologous transplantation. The aim of this study was to observe the mineralization gene expression dental (DPCs) following treatment with snail mucus. Snail mucus collected from adult Achatina fulica processed as a dry powder by freeze-drying technique. dissolved culture medium at concentration 15 μg/mL. DPCs were prepared outgrowth technique cultured 6-well plate density 5...
Bone marrow-derived mesenchymal stem cells (MSCs) show antifibrotic activity in various chronic kidney diseases. Here, we aimed to investigate whether Calycosin (CA), a phytoestrogen, could enhance the of MSCs primary tubular epithelial (PTECs) induced by TGF-β1 and mouse model unilateral ureteral obstruction (UUO). We found that treatment significantly inhibited fibrosis, CA pretreatment enhanced effects on fibrosis vitro. Consistent with vitro studies, alleviated injury renal mice after...
The present study focuses on mechanotransduction in mesenchymal stem cells (MSCs) response to matrix elasticity. By using photocurable gelatinous gels with tunable stiffness, proteomic profiles of MSCs cultured tissue culture plastic, soft (3 kPa) and stiff (52 matrices were deciphered 2-dimensional differential in-gel analysis (2D-DIGE). DIGE data, tied immunofluorescence, indicated abundance organization changes the cytoskeletonal proteins as well regulation important signaling-related...
Saturation DiGE is a powerful but challenging technique for the characterisation of changes in protein expression between two or more scarce samples. In this paper, measures to prevent and troubleshoot artefacts saturation workflow are discussed, with illustration some examples as they may be encountered gel images analysis.
Introduction: The addition of herbs into hot sesame oil could increase the oil-pulling efficiency oil. aim present study was to modify proportion and with other ingredients including menthol, camphor, borneol improve medicinal properties scent Methods: Macerated herbal prepared by heat extraction five species (Zingiber cassumunar, Zingiber zerumbet, Plantago major Linn, Citrus hystrix, Amomum biflorum) performed evaluate anti-oxidant, anti-inflammatory, anti-bacterial this macerated Results:...
Hepatocellular carcinoma (HCC) is one of the most leading causes cancer death with a poor prognosis. However, underlying molecular mechanisms are largely unclear, and effective treatment for it limited. Using an integrated bioinformatics method, present study aimed to identify key candidate prognostic genes that involved in HCC development small-molecule drugs potential.In this study, by using three expression profile datasets from Gene Expression Omnibus database, 1,704 differentially...
Human skeletal stem cells (STRO-1 positive) display distinct responses to different topographical features. On a flat surface, spread, and in vitro, they typically polarized, fibroblast-like morphology. However, on microgrooved surfaces, these prefer stretch along the grooves forming similar morphology vivo, bipolarized fibroblasts. In contrast, nanopits, polygonal osteoblastic phenotype. We have examined mechanotransduction events of STRO-1 positive response fibroblastic, osteogenic,...
Abstract: Adipose-derived stem cells (ADSCs) showed morphological change to a neuron-like shape, and presented neuronal lineage bias when cultured on very soft surface. To gain basic insight into gene expression relating in ADSCs, we examined the correlation between levels of markers redox proteins that were considered have close relation with specification cells. ADSCs gelatinous hydrogel for 1-2 weeks. The time course changes expressions genes (TUBB3 NSE) (TRX1, SOD1, SOD2, PRX2, GSTT1,...
Gelatin is a common material used in tissue engineering and hydroxyapatite (HA) has composition structure similar to natural bone mineral. HA also increase the adhesion ability of scaffolds. The physical mechanical properties gelatin, together with chemical HA, can affect cell differentiation. main purpose this study investigate gene expression human mesenchymal stem cells (HMSCs) upon culturing on gelatin composite HA. Low amounts were introduced into order modulate gelatin. Three types...
Bone marrow-derived mesenchymal stem cells (MSCs) show podocyte-protective effects in chronic kidney disease. Calycosin (CA), a phytoestrogen, is isolated from