A5079558317- Renal and related cancers
- Chronic Kidney Disease and Diabetes
- TGF-β signaling in diseases
- Renal Diseases and Glomerulopathies
- Kruppel-like factors research
- Intracerebral and Subarachnoid Hemorrhage Research
- RNA Research and Splicing
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Genetic and Kidney Cyst Diseases
- Cerebral Palsy and Movement Disorders
- Renal cell carcinoma treatment
- Pancreatic function and diabetes
- Cardiac Fibrosis and Remodeling
- Cancer-related gene regulation
- RNA regulation and disease
- Genetic Syndromes and Imprinting
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Neonatal and fetal brain pathology
- Ginseng Biological Effects and Applications
- Folate and B Vitamins Research
- Acute Ischemic Stroke Management
- Helicobacter pylori-related gastroenterology studies
- Neurological Disease Mechanisms and Treatments
Southwest Medical University
2016-2025
Chengdu University of Traditional Chinese Medicine
2022-2024
Chinese University of Hong Kong
2019-2023
Affiliated Hospital of Southwest Medical University
2021-2023
Guangdong Academy of Medical Sciences
2023
Guangdong Provincial People's Hospital
2023
Weatherford College
2022
Huai'an City Fourth People's Hospital
2019
Chongqing Medical University
2013-2016
First Affiliated Hospital of Sichuan Medical University
2015-2016
Abstract Epididymal white adipose tissue (eWAT) secretes an array of cytokines to regulate the metabolism organs and tissues in high-fat diet (HFD)-induced obesity, but its effects on bone are not well understood. Here, we report that macrophages eWAT a main source osteopontin, which selectively circulates marrow promotes degradation matrix by activating osteoclasts, as modulating marrow-derived (BMDMs) engulf lipid droplets released from adipocytes mice. However, lactate accumulation...
CYP3A4 metabolizes more than 50% of the drugs on market. The large inter-individual differences expression may contribute to variability human drug responses. Post-transcriptional regulation is poorly understood, whereas transcriptional has been studied much thoroughly. In this study, we used multiple software programs predict miRNAs that might bind and identified 112 potentially functional miRNAs. Then a luciferase reporter system was assess effect overexpression each miRNA in HEK 293T...
The relationship between genetic factors and the development of cerebral palsy (CP) has recently attracted much attention. Polymorphisms in genes encoding proinflammatory cytokines have been shown to be associated with susceptibility perinatal brain injury CP. Interleukin-6 (IL-6) is a cytokine that plays pivotal role neonatal injury, but conflicting results reported regarding association IL-6 single nucleotide polymorphisms (SNPs) purpose this study was analyze gene protein expression...
BACKGROUND Fibrosis is the common pathological feature in most kinds of chronic kidney disease (CKD). TGF-β/Smads signaling master pathway regulating fibrosis pathogenesis, which Smad3 acts as integrator various pro-fibrosis signals. In this study, we analyzed role SIS3, a specific inhibitor Smad3, mouse unilateral ureteral obstruction (UUO) kidneys. MATERIAL AND METHODS UUO mice were intraperitoneally injected with 0.2 mg/kg/day or 2 SIS3 control saline for 7 days, followed by analysis...
Podocyte injury plays a critical role in the progression of focal segmental glomerulosclerosis (FSGS). Here, it is reported that B-cell translocation gene 2 (Btg2) promotes Adriamycin (ADR)-induced FSGS via Smad3-dependent podocyte-mesenchymal transition. It found patients and animal models, Btg2 markedly upregulated by podocytes correlated with progressive renal injury. Podocyte-specific deletion protected against onset proteinuria ADR-treated mice along inhibition EMT markers such as α-SMA...
Background: Intracerebral hemorrhage (ICH), a devastating form of stroke, is characterized by elevated morbidity and mortality rates. Neuroinflammation common occurrence following ICH. Mesenchymal stem cells (MSCs) have exhibited potential in treating brain diseases due to their anti-inflammatory properties. However, the therapeutic efficacy MSCs limited intense inflammatory response at transplantation site Hence, enhancing function transplanted holds considerable promise as strategy for...
The upregulation of Wnt/β-catenin signaling occurs in virtually all types kidney disease and is associated with podocyte injury. However, the precise mechanisms involved development remain to be elucidated. MicroRNAs (miRNAs or miRs) are a class short non-coding RNAs they have been shown regulators gene expression, mainly by binding untranslated region (UTR) mRNAs. aim present study was determine role 2 members miR-135 family (miR‑135a miR‑135b) injury elucidate responsible for damage...
Abstract Alpha lipoic acid (ALA) is a powerful antioxidant which has been widely used in the treatment of different system diseases, such as cardiovascular and cerebrovascular diseases. But, there are few studies that refer to protective effects potential mechanisms on traumatic brain injury (TBI). This study was carried out investigate neuroprotective effect following TBI illuminate underlying mechanism. Weight drop‐injured model rats induced by weight‐drop. ALA administrated via...
Neuropeptide Y (NPY) is produced by the nerve system and may contribute to progression of CKD.The present study found new protective role for NPY in AKI both patients animal models.Interestingly, was constitutively expressed blood resident kidney macrophages co-expressing CD68+ markers, which lost mice with AKI-induced cisplatin.Unexpectedly, renoprotective as lacking developed worse renal necroinflammation dysfunction cisplatin ischemic-induced AKI.Importantly, also a therapeutic agent...
Previous studies have highlighted the significant impact of income on access to palliative care. However, few explored treatment preferences low-income patients with advanced cancer. These individuals require additional support in terms care, including financial psychological, spiritual, and social assistance. Therefore, it is essential conduct more qualitative research a particular emphasis this population. To explore preference influencing factors care among cancer mainland China. A study...
Targeted therapy has a pivotal role for the treatment of liver cancer. The aim this current study was to examine effects decursin on growth HepG2 cells and underlying mechanisms. Our present showed that with significantly inhibited by suppressing cell proliferation, cycle arresting, promoting apoptosis in dose‐ time‐dependent manner. Most significantly, administration dramatically impeded vivo tumor nude mice. Mechanically, it is noteworthy provoked degradation YAP upregulating expression...
Highly purified mouse glomeruli are of great value for studying glomerulus-associated kidney diseases. Here, we developed a simple and rapid procedure glomerular isolation with large quantity high purity based on the combination size-selective sieving differential adhesion techniques, which termed “differential method.” In this method, renal cortices were minced digested collagenase. Glomeruli disassociated from tubules by successive through 105-, 75-, 40-μm cell strainers. The retained...
Rationale: Transforming Growth Factor-beta (TGF-β) /Smad3 signaling has been shown to play important roles in fibrotic and inflammatory diseases, but its role beta cell function type 2 diabetes is unknown. Methods: The of Smad3 under condition was investigated by genetically deleting from db/db mice. Phenotypic changes pancreatic islets were compared between knockout (Smad3KO-db/db) mice wild-type (Smad3WT-db/db) mice, other littermate controls. Islet-specific RNA-sequencing performed...
Abstract Background Intracerebral hemorrhage (ICH) is a severe brain-injured disease accompanied by cerebral edema, inflammation, and subsequent neurological deficits. Mesenchymal stem cells (MSCs) transplantation has been used as neuroprotective therapy in nervous system diseases because of its anti-inflammatory effect. Nevertheless, the biological characteristics transplanted MSCs, including survival rate, viability, effectiveness, are restricted inflammatory response after ICH. Therefore,...