A5101985464- Kruppel-like factors research
- Ferroptosis and cancer prognosis
- Environmental Impact and Sustainability
- Energy, Environment, Economic Growth
- Chemotherapy-induced organ toxicity mitigation
- Lung Cancer Treatments and Mutations
- Chronic Kidney Disease and Diabetes
- Renal and related cancers
- Cancer Mechanisms and Therapy
- Genetics and Neurodevelopmental Disorders
- Optical measurement and interference techniques
- RNA modifications and cancer
- Diagnosis and treatment of tuberculosis
- Advanced Glycation End Products research
- Plant Molecular Biology Research
- Renal Diseases and Glomerulopathies
- Dermatologic Treatments and Research
- Acute Kidney Injury Research
- Obstructive Sleep Apnea Research
- Sarcoma Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Environmental Sustainability in Business
- Mycobacterium research and diagnosis
- Wound Healing and Treatments
- Smart Parking Systems Research
Nanjing Maternity and Child Health Care Hospital
2025
Nanjing Medical University
2014-2025
Third Affiliated Hospital of Zhengzhou University
2018-2025
Beijing University of Technology
2019-2024
Peking University
2019-2024
Guiyang Medical University
2022-2024
Wuhan University
2024
Renmin Hospital of Wuhan University
2024
Beijing Tsinghua Chang Gung Hospital
2024
Tsinghua University
2024
Abstract The 5′ region of the mitochondrial DNA (mtDNA) gene cytochrome c oxidase I (COI) is standard marker for barcoding. However, because COI tends to be highly variable in amphibians, sequencing often challenging. Consequently, another mtDNA gene, 16S rRNA advocated amphibian Herein, we directly compare usefulness and discriminating species hynobiid salamanders using 130 individuals. Species identification classification these animals, which are endemic Asia, based on morphology only....
Diabetic nephropathy (DN) is one of the most common complications diabetes mellitus (DM). However, exact mechanism not clearly understood. In this study, our results showed that 24 h urinary protein, kidney index, and glomerular area were decreased, while creatinine clearance ratio was increased in DN rats when treated with NAR 50 mg/d for 6 weeks. Mesangial cell (MMCs) proliferation inhibited group by 3,(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), cycle analysis...
Abstract Background Breast cancer and reproductive system cancers remain significant public health threats for Chinese women. This study aimed to evaluate the latest epidemiological patterns trends of four female‐specific in China. Methods The year‐ age‐specific estimates incidence, mortality, disability‐adjusted life‐years (DALYs) associated with breast, cervical, ovarian, uterine China from 1990 2021 were generated Global Burden Disease, Injuries, Risk Factors study. characteristics...
The upregulation of Wnt/β-catenin signaling occurs in virtually all types kidney disease and is associated with podocyte injury. However, the precise mechanisms involved development remain to be elucidated. MicroRNAs (miRNAs or miRs) are a class short non-coding RNAs they have been shown regulators gene expression, mainly by binding untranslated region (UTR) mRNAs. aim present study was determine role 2 members miR-135 family (miR‑135a miR‑135b) injury elucidate responsible for damage...
Colorectal cancer (CRC) is a devastating disease with high mortality and morbidity, the underlying mechanisms of miR-19a in CRC are poorly understood. In our study, dual-luciferase reporter assays were used to evaluate binding thrombospondin-1 (THBS1). Cell viability, migration, invasiveness assessed using MTT, wound healing, Transwell assays, respectively. Tube-formation human lymphatic endothelial cells (HLECs) lymphangiogenesis, tumor xenograft measure growth. The results showed that was...
Gastric cancer (GC) is one of the most common malignancies digestive system with few genetic markers for its early detection and prevention. In this study, differentially expressed genes (DEGs) were analyzed using GEO2R from GSE54129 GSE13911 Gene Expression Omnibus (GEO). Then, gene enrichment analysis, protein-protein interaction (PPI) network construction, topological analysis performed on DEGs by Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG) pathway, STRING, Cytoscape. Finally,...
MicroRNAs (miRNAs) possess an important regulating effect among numerous renal diseases, while their functions in the process of epithelial-to-mesenchymal transition (EMT) after podocyte injury remain unclear. The purpose our study is to identify potential miR-30a EMT podocytes and explore underlying mechanisms impaired podocytes. results revealed that downregulation animal models patients, highly induced mesenchymal markers including Collagen I, Fibronectin Snail. Furthermore,...
Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer and has poor outcomes. However, potential molecular biological process underpinning occurrence development of HCC still largely unknown. The purpose this study was to identify core genes related explore their events using bioinformatics methods. HCC-related expression profiles GSE25097 GSE84005 were selected from Gene Expression Omnibus (GEO) database, differentially expressed (DEGs) between 306 tissues 281...
Ranunculus ternatus Thunb (Ranunculaceae), (RTT) is used clinically for the treatment of tuberculosis or as tumour adjuvant therapy, but its potential effect on diabetic nephropathy (DN) has not been studied.To investigate RTT extract in renal fibrosis DN.C57BL/6 mice were randomly divided into four groups (n = 12). Diabetes mellitus (DM) induced by streptozotocin (STZ, 55 mg/kg/day) five consecutive days and treated (2 g/kg). Afterward, blood glucose, HE Masson staining assayed. The...
Colorectal cancer (CRC) is the third major cause of cancer-related death worldwide, and fluorouracil (5-FU) widely used in treatment CRC. However, acquired resistance to 5-FU has become an obstacle effective Adenosine triphosphate (ATP)-binding cassette sub-family G member 2 (ABCG2) been found highly expressed CRC patients with poor responsiveness folinic acid/5-FU/irinotecan. mechanisms regulated by ABCG2 cells remain be comprehensively understood. We aimed explore upstream involved...
Purpose: As a third-generation EGFR TKI has been taken orally, Osimertinib effectively inhibits mutant EGFR, including T790M resistance mutations. Here, we examined real-world efficacy and tolerability of among Chinese patients with advanced T790M-mutant NSCLC. Patients Methods: A total 106 NSCLC who were taking following disease progression after EGFR-TKIs or other treatments retrospectively recruited in this study. The PFS OS treatment analyzed as the primary endpoints. Results: was used...
Diabetic nephropathy (DN) is one of the chronic microvascular diseases diabetes. Studies revealed that inflammation involved in development DN. However, its mechanisms are not fully clear. Here, we screened DN-related mRNAs by RNA sequencing renal tissues db/db DN mice and normal control mice. The Swiss-Model, ZDOCK 3.0.2 PyMOL 2.3.2 were applied for bioinformatics analysis. In total, obtained 6,820 dysexpressed Among them, Receptor Activated C Kinase 1 (Rack1) was focused on high fold...
Renal cell carcinoma (RCC) is one of the most common malignancies globally, among which clear (ccRCC) accounts for 85-90% all pathological types. This study aims to screen out potential genes in metastatic ccRCC so as provide novel insights treatment.GSE53757 and GSE84546 datasets Gene Expression Omnibus (GEO) were profiled identify differentially expressed (DEGs) from samples with or without metastasis. The Kyoto Encyclopedia Genes Genomes (KEGG) gene ontology (GO) analysis performed...
Downregulation of the WW domain containing oxidoreductase (WWOX) has been reported to be involved in tumorigenesis several neoplasms. This study sought investigate expression and role WWOX intrahepatic cholangiocarcinoma (ICC).WWOX was measured by quantitative real-time polymerase chain reaction (PCR), immunoblot, immunofluorescence, immunohistochemistry. The prognostic significance assessed Kaplan-Meier Cox regression analyses. proliferation, anchorage-independent growth, gene regulation,...
Fibroblasts in keloids undergo cell identity transition with altered transcriptional characteristics. However, the core transcription factors driving this cellular reprogramming remain largely unknown. Here, we report results of profiling from 48 keloid and 24 control dermal tissues. We identified 1187 upregulated differentially expressed genes (foldchange > 2, false discovery rate < 0.05) keloids, which were mainly enriched extracellular matrix organization bone/cartilage development,...
Introduction The gut microbiota participates in multiple human biological processes, including metabolism and immune responses. During pregnancy, the dynamics of is involved physiological adaptation. disturbed profile microbiome associated with maternal complications, such as gestational diabetes mellitus (GDM), which further transfers to offspring influence their metabolic immunological functions long term. Prebiotics targeting modulating have been shown be effective non-pregnant...