A5090381942- Lung Cancer Treatments and Mutations
- Pharmacogenetics and Drug Metabolism
- Dermatologic Treatments and Research
- Wound Healing and Treatments
- Pharmacological Effects of Natural Compounds
- PI3K/AKT/mTOR signaling in cancer
- Retinal Diseases and Treatments
- Advanced Breast Cancer Therapies
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Pharmaceutical Economics and Policy
- Neurological Disease Mechanisms and Treatments
- Retinal and Macular Surgery
- Lipoproteins and Cardiovascular Health
- Cancer Treatment and Pharmacology
- Alzheimer's disease research and treatments
- Cancer therapeutics and mechanisms
- Nonmelanoma Skin Cancer Studies
- Medicinal Plants and Bioactive Compounds
- Biotin and Related Studies
- Aluminum toxicity and tolerance in plants and animals
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
- Neuroscience and Neural Engineering
- Pneumocystis jirovecii pneumonia detection and treatment
Peking University
2020-2024
National Clinical Research Center for Digestive Diseases
2020-2024
Peking University First Hospital
2020-2024
Qingdao University
2013-2024
Affiliated Hospital of Qingdao University
2020-2024
Wenzhou Hospital of Traditional Chinese Medicine
2024
Zhejiang Chinese Medical University
2024
National Medical Products Administration
2022-2023
Ningbo First Hospital
2021-2023
Hudson Institute
2022-2023
Adverse skin reactions among healthcare workers during the coronavirus disease 2019 outbreak: a survey in Wuhan and its surrounding regions
Chronic exposure to trichothecenes is known disturb insulin-like growth factor 1 and signaling of insulin leptin hormones causes considerable retardation in animals. However, limited information was available on mechanisms underlying trichothecene-induced retardation. In this study, we employed an integrated transcriptomics, proteomics, RNA interference (RNAi) approach study the molecular trichothecene cytotoxicity rat pituitary adenoma GH3 cells. Our results showed that suppressed synthesis...
Oxidative stress is believed to be an important inducer of cellular senescence and aging. Zinc finger protein 637 (Zfp637), which belongs the Krüppel-like family, has been hypothesized play a role in oxidative stress. Nevertheless, precise function Zfp637 seldom reported, it remains unclear whether involved stress-induced premature senescence. In this study, we show that endogenous expression levels mouse telomerase reverse transcriptase (mTERT) are downregulated during senescent tissues...
Abstract Holliday junction recognition protein (HJURP) refers to a histone H3 chaperone that has been implicated in different kinds of malignancies. Yet, its character pancreatic cancer remains unclear. The expression HJURP was assessed PDAC tissues by RT-qPCR, immunoblotting, and immunohistochemistry. HJURP-deficient or overexpressed cell lines were constructed, using shRNA plasmids with insert. MTT, sphere formation assay, migration, invasion assays performed evaluate the viability,...
The epidermal growth factor receptor (EGFR), a ubiquitously expressed tyrosine kinase, is recognized as key mediator of tumorigenesis in many human epithelial tumors. Erlotinib kinase inhibitor approved by FDA for use oncology. It inhibits the intracellular phosphorylation associated with EGFR to restrain development tumor. To investigate antitumor effect erlotinib at different dosing times and underlying molecular mechanism via PI3K/AKT pathway, we established mouse model Lewis lung cancer...
Aim: VDJ001 is a novel recombinant humanized monoclonal antibody against the anti-interleukin-6 receptor. As an analog of tocilizumab, it exhibited improved affinity and in vitro activity. Based on preclinical studies, first-in-human clinical study was conducted to evaluate safety, tolerability, pharmacokinetics VDJ001. Methods: This single-center, randomized, double-blinded, placebo-controlled phase I dose-escalation healthy Chinese volunteers. Four cohorts were designed with dosages...
The protective effects and mechanisms of esculetin on doxorubicin (DOX)-induced injury H9c2 cells were investigated. cultured the logarithmic growth phase was divided into a control group, DOX group an + group. Cell viability detected by MTT assay. Annexin V-PI (AV-PI) double staining flow cytometry carried out to detect cell apoptosis. Intracellular reactive oxygen species (ROS) cytometry. Transmission electron microscope (TEM) used evaluate ultrastructure. Cleaved caspase-3, cleaved PARP,...
Abstract Introduction/Background TQH2722 is a humanized monoclonal antibody targeting interleukin 4 receptor alpha (IL4Rα) which leads to the dual-blockade of interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling, inhibiting T-helper cell type 2 immune pathway. Th2 inflammation implicated in pathobiology diseases such as asthma atopic dermatitis. We describe safety pharmacokinetic results from first-in-human study healthy subjects. Objectives To evaluate safety, tolerability,...
Purpose: Safety, tolerability and pharmacokinetics of single multiple ascending doses (SADs/MADs) benfotiamine were assessed after oral administration in two randomized, double-blind, placebo-controlled, phase I trials. Methods: Healthy subjects sequentially enrolled into one five SAD (150– 1200 mg) or three MAD (150, 300 600 cohorts. In study, each cohort 12 (n = 10, active; n 2, placebo) administrated once-daily doses. 16 12, 4, on day 1 twice-daily 4– 9, followed by a morning dose 10....
Abstract Background Ezetimibe is a new class of antihyperlipidemic agent indicated for the prevention atherosclerosis disease and treatment hypercholesterolemia. Information on pharmacokinetic profiles ezetimibe tablet in healthy Chinese volunteers are lacking, regulatory requirements necessitate bioequivalence study versus Ezetrol® China. Methods A single-dose randomized, open-label, two-group, two-period crossover was conducted 59 under fasting or fed conditions to assess between two...
The effects of body weight cycling (WC) in rats on composition (BC) and feeding efficiency were studied. usefulness estimating BC by bioelectrical impedance analysis (BIA) was also examined. Female Sprague-Dawley divided into high-fat ad libitum feeding, either noncycling or cycling, restricted (75% control feed) groups. Control fed a regular laboratory diet did not cycle. All killed at the end week 61. A BIA unit used each stage WC to obtain resistance reactance readings. Final determined...
Fibroblasts in keloids undergo cell identity transition with altered transcriptional characteristics. However, the core transcription factors driving this cellular reprogramming remain largely unknown. Here, we report results of profiling from 48 keloid and 24 control dermal tissues. We identified 1187 upregulated differentially expressed genes (foldchange > 2, false discovery rate < 0.05) keloids, which were mainly enriched extracellular matrix organization bone/cartilage development,...