A5100419192- Cancer-related gene regulation
- Chronic Lymphocytic Leukemia Research
- PI3K/AKT/mTOR signaling in cancer
- Chronic Myeloid Leukemia Treatments
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Traffic Prediction and Management Techniques
- MicroRNA in disease regulation
- Tissue Engineering and Regenerative Medicine
- Advanced Drug Delivery Systems
- Medicinal Plant Pharmacodynamics Research
- Robotics and Sensor-Based Localization
- Advanced biosensing and bioanalysis techniques
- Mineral Processing and Grinding
- Hippo pathway signaling and YAP/TAZ
- Lung Cancer Treatments and Mutations
- Geoscience and Mining Technology
- Advanced Image and Video Retrieval Techniques
- Additive Manufacturing and 3D Printing Technologies
- Human Mobility and Location-Based Analysis
- High-Voltage Power Transmission Systems
- Phonetics and Phonology Research
- Pharmacological Effects of Natural Compounds
- Vehicle emissions and performance
- Biosensors and Analytical Detection
Shaoguan University
2025
Russian State University for Physical Education Sport Youth and Tourism
2024
Dalian University of Technology
2023-2024
Qingdao University
2022-2024
Stomatology Hospital
2022-2024
Zhejiang University
2022-2024
Jiangsu Province Hospital
2023-2024
The University of Texas Health Science Center at San Antonio
2024
Chongqing University
2022-2024
Affiliated Hospital of Qingdao University
2023-2024
Predictive biomarkers of response are essential to effectively guide targeted cancer treatment. Ataxia telangiectasia and Rad3-related kinase inhibitors (ATRi) have been shown be synthetic lethal with loss function (LOF) ataxia telangiectasia-mutated (ATM) kinase, preclinical studies identified ATRi-sensitizing alterations in other DNA damage (DDR) genes. Here we report the results from module 1 an ongoing phase trial ATRi camonsertib (RP-3500) 120 patients advanced solid tumors harboring...
Abstract Dental caries caused by oral microbiome dysbiosis with the elevation of acidogenic bacteria is most prevalent non-communicable disease worldwide. Early prevention and timely fluoride treatment are crucial for lesion management. Herein, to address challenges in situ sensing topical drug delivery within cavity, a miniaturized, battery-free, wearable dental patch system was developed microenvironment monitoring controlled treatment. With integration near-field communication, realizes...
Considering the increasing environmental pressure, environmentally friendly and high-performance water-based drilling fluids (WBDFs) have been widely studied in recent years to replace commonly used oil-based (OBDFs). However, few of these are entirely composed natural materials, which makes it difficult achieve real protection. Using laponite nanoparticles various derivatives including crosslinked starch, cellulose composite, gelatin ammonium salt, poly-l-arginine, polyanionic cellulose, a...
The Hippo pathway plays a central role in tissue development and homeostasis. However, the function of pancreatic endocrine remains obscure. Here, we generated novel conditional genetically engineered mouse models to examine roles pathway-mediated YAP1/TAZ inhibition stages specification differentiation. While YAP1 protein was localized nuclei bipotent progenitor cells, Neurogenin 3 expressing progenitors completely lost expression. Using models, found that inactivation requires both an...
Summary Plants adjust the size of their stomatal openings to balance CO 2 intake and water loss. Carbonic anhydrases (CAs) facilitate conversion between HCO 3 − , OsβCA1 mutant in rice ( Oryza sativa ) shows similar traits carbon fixation response as dual βCA mutants Arabidopsis thaliana . However, exact role these processes was unclear. We used gene editing, molecular biology, plant physiology study how contributes fixation, opening, responses. produces three isoforms (OsβCA1A, OsβCA1B,...
As the percentage of lithium-ion batteries as in a system for storing energy gradually rises, accidents brought by deterioration battery performance continue to occur. The solution guaranteeing steady operation this is learning how precisely forecast batteries' remaining useful life (RUL). A prediction framework that combines elements incremental capacity analysis (ICA) and electrochemical impedance spectroscopy (EIS) proposed address issues RUL. initially examines charging discharging...
In order to explore the effect of printing parameter configurations on forming performance Digital Light Processing (DLP) 3D printed samples, experiments were carried out enhanced adhesion and efficient demolding DLP devices. The molding accuracy mechanical properties samples with different thickness tested. test results show that when layer increases from 0.02 mm 0.22 mm, dimensional in X Y directions first then decreases, while Z direction is highest 0.1 mm. decline an increasing samples....
In order to study the effect of calcium sulfate whiskers and carbonate on road performance asphalt mixtures, high temperature stability, low performance, change water two with different dosage levels mixture was obtained. The test results show that can improve stability within a certain level range, but has no obvious improvement effect, adding excessive will reduce performance. addition significantly mixture. Under same level, in improving is better than whiskers. When content whisker 0.4%, best.
A novel forming method of enhanced adhesion-efficient demolding integration is proposed to solve the problems weak adhesion between initial layer and printing platform as well excessive stripping force at bottom liquid tank when rises. Therefore, a digital light processing (DLP) 3D device equipped with porous replaceable swing mechanism for manufactured verified by experiments. The experimental results show that can enhance improve efficiency device. In addition, pull-out design plate...
Different from surface plasmon resonance (SPR) that only can be excited by <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mi>p</mml:mi> </mml:math> -polarized light, lossy mode (LMR) achieved with both - and <mml:mi>s</mml:mi> thus providing a pathway for enhanced transverse spin-dependent shift (SDS) of the photonic spin Hall effect (PSHE) horizontal vertical polarization states. The maximum SDSs 13.28 µm 7.64 states are achieved, respectively, which about...
Abstract Peanut ( Arachis hypogea L.) yield is dramatically declined by extreme weather stresses under climate change. Adjusting the sowing date and plant density are effective strategies to mitigate these improve peanut yield. However, a mechanistic understanding of influence environmental drivers an optimized strategy have yet be developed. Here, 3‐year field experiment was conducted evaluate (April 25, early sowing; May 5, middle 15, late sowing) (24, 30, 36 plants m −2 as low, medium,...
Background & Aims: Acinar-to-ductal metaplasia (ADM) serves as a precursor event in the development of pancreatic ductal adenocarcinoma (PDAC) upon constitutive environmental and genetical stress. While role ADM PDAC progression has been established, molecular mechanisms underlying human remain elusive. We previously demonstrated induction acinar cells through transforming growth factor beta (TGFβ) signaling pathway. aim to investigate interaction between TGFβ Hippo pathways mediating...
Aim: VDJ001 is a novel recombinant humanized monoclonal antibody against the anti-interleukin-6 receptor. As an analog of tocilizumab, it exhibited improved affinity and in vitro activity. Based on preclinical studies, first-in-human clinical study was conducted to evaluate safety, tolerability, pharmacokinetics VDJ001. Methods: This single-center, randomized, double-blinded, placebo-controlled phase I dose-escalation healthy Chinese volunteers. Four cohorts were designed with dosages...