A5100610315- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac Fibrosis and Remodeling
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Nutritional Studies and Diet
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Disease and Adiposity
- Traditional Chinese Medicine Studies
- Cardiac pacing and defibrillation studies
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Treatment and Management
- Nutrition and Health in Aging
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Risk Factors
- Antioxidant Activity and Oxidative Stress
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Tissue Engineering and Regenerative Medicine
- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Heavy Metal Exposure and Toxicity
- Lipoproteins and Cardiovascular Health
Jiangsu Province Hospital
2016-2025
Nanjing Medical University
2016-2025
Peking University
2024
Second Xiangya Hospital of Central South University
2024
Central South University
2008-2024
Fudan University
2024
Zhongshan Hospital
2024
National Centre for Disease Prevention and Control
2024
Mackay Memorial Hospital
2019-2021
Weatherford College
2020
Background Systemic oxidative stress is involved in the development of hypertension, whereas carotenoids are a group natural antioxidants. Our study aims to evaluate relationships between serum concentrations major and mortality hypertensive adults. Methods Results Data on 5 from National Health Nutrition Examination Survey (NHANES) III NHANES 2001-2006 were included. Outcome measures (all-cause cardiovascular mortality) identified Death Index through December 31, 2019. Multiple Cox...
Background/Aims: Acute myocardial infarction (AMI) represents a major cause of morbidity and mortality worldwide. Exercise has been proved to reduce ischemia-reperfusion (I/R) injury However it remains unclear whether, (if so) how, exercise could protect against AMI. Methods: Mice were trained using 3-week swimming protocol, then subjected left coronary artery (LCA) ligation, finally sacrificed 24 h after Myocardial infarct size was examined with triphenyltetrazolium chloride staining....
Background Data comparing outcomes in heart failure ( HF ) across Asia are limited. We examined regional variation mortality among patients with enrolled the ASIAN ‐HF (Asian Sudden Cardiac Death Heart Failure) registry separate analyses for those reduced ejection fraction EF ; <40%) versus preserved (≥50%). Methods and Results The ‐ is a prospective longitudinal study. Participants symptomatic were recruited from 46 secondary care centers 3 Asian regions: South (India), Southeast...
Abstract Amino-functionalized graphene oxide (GO-NH 2 ) was synthesized by grafting (3-aminopropyl) triethoxysilane on the (GO) surface. The GO-NH with high surface area and numerous active sites can efficiently adsorb Cr(VI), Cu(II), Pb(II) Cd(II) ions. maximum adsorption capacities of for were 280.11, 26.25, 71.89 10.04 mg g −1 , respectively. pseudo-first-order pseudo-second-order kinetic models employed to describe processes. experimental data agreed well equation, heavy metals onto...
BackgroundHeart failure (HF) and dementia frequently co-exist with shared pathological mechanisms risk factors. Our study aims to investigate the association between statin therapy risks of its subtypes among patients HF.MethodsThe Hong Kong Clinical Data Analysis Reporting System database was interrogated identify incident HF diagnosis from 2004 2018, using ICD 9/ICD 10 codes. Inverse probability treatment weighting (IPTW) used balance baseline covariates users (N = 54,004) non-users...
Objective Systemic inflammation is associated with a poor prognosis in acute heart failure (AHF). This study was to assess the long-term prognostic value of combining accessible inflammatory markers relation all-cause mortality patients AHF. Methods Consecutive AHF who were hospitalized between March 2012 and April 2016 at Department Cardiology First Affiliated Hospital Nanjing Medical University enrolled this prospective study. The LASSO regression model used select most valuable biomarkers...
The nonlinear associations of serum perfluoroalkyl acids (PFAAs) with hypertension and blood pressure have not been addressed. Cross-sectional data from 6967 adults (age ≥ 20 years) the 2003-2012 National Health Nutrition Examination Survey (NHANES) were analyzed. Hypertension was defined as an average systolic above 140 mmHg, diastolic 90 mmHg or self-reported use prescribed medicine for diagnosed hypertension. After multivariable adjustment, compared lowest tertile, odds ratios (ORs) 95%...
Allisartan isoproxil is a new nonpeptide angiotensin II receptor blocker (ARB) precursor drug that used to treat hypertension and reduce the risk of heart disease. The present study explored effects allisartan on diabetic cardiomyopathy (DCM) revealed roles hyperglycaemia‑induced oxidative stress inflammation. A rat DCM model was established by high‑fat diet feeding in combination with intraperitoneal injection streptozocin. Echocardiographs showed rats exhibited significantly decreased...
Background: Antioxidant micronutrients represent an important therapeutic option for the treatment of oxidative stress-associated cardiovascular diseases (CVDs). However, few studies have evaluated relationship between levels multiple dietary antioxidants and CVDs. Objective: The study therefore aimed to evaluate associations total specific CVDs among a nationally representative sample adults in US. Design: In total, 39,757 (>20 years) were included this cross-sectional from 2005-2018...
In the present study, we observed a rapid and robust activation of ribosomal protein S6K (S6 kinase) provoked by MI (myocardial infarction) in mice. As promotes cell growth, hypothesized that increased activity contributes to pathological cardiac remodelling after suppression may prevent aberrant improve function. mice, administration rapamycin effectively suppressed heart significantly improved function MI. The weight/body weight ratio fibrotic area were substantially reduced...
The effect of aldehyde exposure on the cardiovascular system remains unclear. objective this study was to determine whether is associated with prevalence disease (CVD). We analyzed associations between aldehydes and CVD using data from 1962 adult participants in National Health Nutrition Examination Survey (NHANES) 2013 2014. Multivariable logistic regression restricted cubic spline models were used examine association CVD. 10.3%. After adjusting for confounding factors, including age, sex,...
Diabetic cardiomyopathy (DCM) is a pathophysiological condition induced by diabetes mellitus that often causes heart failure (HF). However, their mechanistic relationships remain unclear. This study aimed to identify immune gene signatures and molecular mechanisms of DCM. Microarray data from the Gene Expression Omnibus (GEO) database patients with DCM were subjected weighted co-expression network analysis (WGCNA) modules. Core expression modules intersected database. We analyzed mapped...
BackgroundThere are strong association between remnant cholesterol (RC)/non-high density lipoprotein (NHDL-C) and increase cardiovascular (CV) risk. The aim of present study was to investigate the target lipid parameters (RC NHDL-C) risk CV mortality in general population.MethodsData set from an open database—National Health Nutrition Examination Surveys (NHANES) 2003–2014 were extracted (n = 14992). Kaplan-Meier, multivariable COX regression, restricted cubic spline (RCS)...
Ethylene oxide (EO) has been shown to associate with increased cardiovascular risk. This study aimed explore the relationship and its meditating factors between EO exposure major risk factor of obesity among general adult population.Cross-sectional data 3,220 participants from National Health Nutritional Examination Survey (NHANES) 2013-2016 were enrolled. Obesity was defined as body mass index (BMI) ≥30 kg/m2, abdominal waist circumference (WC) ≥102 cm in men ≥88 women. The association...
Abstract Aims The prevalence of metabolic syndrome (MetS) is increasing due to ageing populations and lifestyle changes, making it crucial understand the relationship between body fat distribution cardiovascular outcomes. Traditional measures such as mass index (BMI) have limitations in assessing abdominal obesity. roundness (BRI), a novel anthropometric measure combining waist circumference height, has shown promise evaluating this risk. This study aims explore association BRI disease (CVD)...