A5091548578- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Structural Anomalies and Repair
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- COVID-19 Clinical Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Mechanical Circulatory Support Devices
- Cardiac Imaging and Diagnostics
- Congenital Anomalies and Fetal Surgery
- Pain Management and Treatment
- Electrochemical Analysis and Applications
- Neuroscience and Neural Engineering
- Viral Infections and Immunology Research
- Drug-Induced Ocular Toxicity
- Pancreatic function and diabetes
- Hemodynamic Monitoring and Therapy
MedStar Franklin Square Medical Center
2024
Care Institute of Medical Sciences
2013-2023
Advanced Materials and Processes Research Institute
2023
Council of Scientific and Industrial Research
2023
Smt. Kashibai Navale Medical College and General hospital
2021-2022
Carle Foundation Hospital
2021
Brigham and Women's Hospital
2019
Harvard University
2019
Cleveland Clinic
2018
Dalhousie University
2014
Human interleukin-12 (hIL-12) is a cytokine with anticancer activity, but its systemic application limited by toxic inflammatory responses. We assessed the safety and biological effects of an hIL-12 gene, transcriptionally regulated oral activator. A multicenter phase 1 dose-escalation trial (NCT02026271) treated 31 patients undergoing resection recurrent high-grade glioma. Resection cavity walls were injected (day 0) fixed dose vector (Ad-RTS-hIL-12). The activator for hIL-12, veledimex...
Background Data comparing outcomes in heart failure ( HF ) across Asia are limited. We examined regional variation mortality among patients with enrolled the ASIAN ‐HF (Asian Sudden Cardiac Death Heart Failure) registry separate analyses for those reduced ejection fraction EF ; <40%) versus preserved (≥50%). Methods and Results The ‐ is a prospective longitudinal study. Participants symptomatic were recruited from 46 secondary care centers 3 Asian regions: South (India), Southeast...
Asians are predisposed to a lean heart failure (HF) phenotype. Data on the 'obesity paradox', reported in Western populations, scarce Asia and have only utilised traditional classification of body mass index (BMI). We aimed investigate association between obesity (defined by BMI abdominal measures) HF outcomes Asia.Utilising Asian Sudden Cardiac Death Heart Failure (ASIAN-HF) registry (11 regions including Taiwan, Hong Kong, China, India, Malaysia, Thailand, Singapore, Indonesia,...
The STICH (Surgical Treatment for Ischemic Heart Failure) trial compared a strategy of routine coronary artery bypass grafting (CABG) with guideline-based medical therapy patients ischemic left ventricular dysfunction.To describe treatment-related quality-of-life (QOL) outcomes, major prespecified secondary end point in the trial.Randomized trial. (ClinicalTrials.gov: NCT00023595).99 clinical sites 22 countries.1212 ejection fraction 0.35 or less and disease.Random assignment to alone (602...
Vulval hematoma during pregnancy is a rare event. Typically, they arise as result of postpartum trauma. Rarely do hematomas this type develop spontaneously labour without any obvious underlying cause for the same. Prompt recognition and timely drainage helps to prevent untoward complication leads speedy recovery.
There is limited data regarding the demographics and type of cardiac implantable electronic device (CIED) in India. The aim this survey was to define trends CIED implants, which included permanent pacemakers (PM), intracardiac defibrillators (ICD), resynchronization therapy (CRT-P/D) devices initiative Indian Society Electrocardiology Heart Rhythm Society. used, their indications, demographic characteristics, clinical status co-morbidities were collected using a form over period 1 year. 2117...
A national atrial fibrillation (AF) registry was conducted under the aegis of Indian Heart Rhythm Society (IHRS), to capture epidemiological data-type AF, clinical presentation and comorbidities, current treatment practices, 1-year follow-up outcomes.A total 1537 patients were enrolled from 24 sites in India IHRS-AF July 2011 August 2012. Their baseline characteristics data recorded case report forms subsequently analyzed.The average age AF 54.7 years. There a marginal female preponderance -...
The effects of acute amiodarone infusion on dynamics ventricular fibrillation (VF) are unclear. Six isolated swine right ventricles (RVs) were studied in vitro. Activation patterns during VF mapped optically, whereas action potentials recorded with a glass microelectrode. At baseline, was associated frequent spontaneous wave breaks. Amiodarone (2.5 μg/ml) reduced breaks and increased the cycle length (CL) from 83.3 ± 17.8 ms at baseline to 118.4 25.8 ( P < 0.05). reentrant front CL (114.4...
Background: Patients with rheumatic heart disease atrial fibrillation incur significant morbidity and mortality. Which approach, ventricular rate control or maintenance of sinus rhythm, in this setting might be superior is not known. The role amiodarone patient population for maintaining rhythm has been evaluated. Methods Results: We prospectively studied 144 patients chronic a double-blind protocol which (group I), comprising 48 each Ia) placebo Ib), were compared other group II) the...
Atrial fibrillation (AF) is the most common sustained arrhythmia with high risk for many cardiovascular (CV) complications. Adherence to recommended management guidelines important avoid In India, there little knowledge on how AF managed in real world. This a cross-sectional study of patients India enrolled RealiseAF survey between February 2010 and March diagnosis within last 12 months. From 15 centers, 301 {mean age 59.9 years (14.4); 52.5% males} were recruited. was controlled 50% 77...
Background: Little is known regarding the impact of socioeconomic factors on use evidence-based therapies and outcomes in patients with heart failure reduced ejection fraction across Asia. Methods: We investigated association both patient-level (household income, education levels) country-level (regional income level by World Bank classification, disparity Gini index) indicators guideline-directed therapy clinical (composite 1-year mortality or HF hospitalization, quality life) prospective...
No or slow reflow following percutaneous coronary intervention (PCI), despite the presence of a patent epicardial vessel, is serious complication resulting in increased morbidity and mortality. In present study, we have evaluated combination therapy adenosine sodium nitroprusside administered as sequential intracoronary (IC) boluses on no-reflow during PCI. Seventy-five high risk acute syndrome patients who underwent PCI with evidence initial less than TIMI (thrombolysis myocardial...
The PANARrhythMia and Heart Failure Registry (PANARM HF) characterized demographic, clinical interventional therapy indication profiles of cardiac arrhythmia (CA) heart failure (HF) patients in India.Consulting Physicians (CP) who medically manage CA HF enrolled with one or more the following: syncope, pre-syncope, dyspnea, palpitation, fatigue LV dysfunction. CPs were trained by cardiologists (IC) to identify CA/HF indicated for implantable device/radiofrequency ablation (RFA). 59 CP's, 16...
The PANORAMA study was designed to collect concurrent data on subjects from different worldwide regions implanted with CRM devices.In this prospective, multi-center study, we analyzed baseline 8586 devices no additional selection criteria (66% pacemaker (IPG), 16% implantable cardiac defibrillators (ICD), 17% resynchronization therapy (CRT) and < 1% Internal Loop Recorder) 156 hospitals across 6 geographical between 2005 2011.Regardless of the device implanted, Middle East India often had...
Congenital cystic adenomatoid malformation (CCAM) encompasses a continuum of hamartomatous lung lesions characterised by the presence abnormal bronchiolar structures varying sizes or distribution. The CCAM is disorder infancy with majority cases being diagnosed within first two years life. We describe in 13-year-old girl complaining recurrent lower respiratory tract infections since who presented post-infectious pneumatocele loculated pleural effusion, and suspected abscess formation had...