A5088739396- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Antiplatelet Therapy and Cardiovascular Diseases
- ECG Monitoring and Analysis
- Acute Ischemic Stroke Management
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Heart Rate Variability and Autonomic Control
- Nursing Roles and Practices
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Interprofessional Education and Collaboration
- Cardiovascular Syncope and Autonomic Disorders
- Venous Thromboembolism Diagnosis and Management
- Acute Myocardial Infarction Research
- SARS-CoV-2 and COVID-19 Research
- Medication Adherence and Compliance
- Cardiovascular Effects of Exercise
- Palliative Care and End-of-Life Issues
- Non-Invasive Vital Sign Monitoring
- Family and Patient Care in Intensive Care Units
National University Heart Centre Singapore
2016-2025
National University of Singapore
2017-2025
National University Hospital
2015-2025
National University Health System
2012-2024
Ng Teng Fong General Hospital
2024
National Heart Centre Singapore
2023
Thrombosis Research Institute
2017
Institute of High Performance Computing
2016
Agency for Science, Technology and Research
2016
Westmead Hospital
2006-2015
Abstract Atrial fibrillation (AF) is the most common sustained arrhythmia, causing a 2‐fold increase in mortality and 5‐fold stroke. The Asian population rapidly aging, 2050, estimated with AF will reach 72 million, of whom 2.9 million may suffer from AF‐associated Therefore, stroke prevention an urgent issue Asia. Many innovative advances management have emerged recently, including new scoring systems for predicting bleeding risks, development non‐vitamin K antagonist oral anticoagulants...
Electric isolation of the pulmonary veins and posterior left atrium with a single ring radiofrequency lesions (single-ring [SRI]) may result in fewer atrial fibrillation (AF) recurrences than wide antral vein (wide [WAI]) by abolishing extravenous AF triggers. The effect mitral isthmus line (MIL) ablation on outcomes after SRI has not previously been assessed.We randomly assigned 220 consecutive patients (58 ± 10 years old; 82% men) highly symptomatic (61% paroxysmal, 39%...
A principal aim of the Global Anticoagulant Registry in FIELD-Atrial Fibrillation (GARFIELD-AF) was to document changes treatment practice for patients with newly diagnosed atrial fibrillation during an era when non–vitamin K antagonist oral anticoagulants (NOACs) were becoming more widely adopted. In these analyses, key factors which determined choice between NOACs and vitamin antagonists (VKAs) are explored. Logistic least absolute shrinkage selection operator regression predictors NOAC...
Despite reports suggesting an association between COVID-19 mRNA vaccination and pericarditis myocarditis, detailed nationwide population-based data are sparsely available. We describe the incidence of myocarditis by age categories sex after from a mass programme in Singapore.The adjudicated cases following that were reported to vaccine safety committee January July 2021 was compared with background Singapore.As end 2021, total 34 (9 only, 14 11 concomitant myocarditis) 7,183,889 doses...
Understanding the trajectories of metabolic risk factors for acute myocardial infarction (AMI) is necessary healthcare policymaking. We estimated future projections incidence diseases in a multi-ethnic population with AMI.The and mortality contributed by AMI (diabetes mellitus [T2DM], hypertension, hyperlipidemia, overweight/obesity, active/previous smokers) were projected up to year 2050, using linear Poisson regression models based on Singapore Myocardial Infarction Registry from 2007...
Background Using data from the GARFIELD ‐ AF (Global Anticoagulant Registry in FIELD –Atrial Fibrillation), we evaluated impact of chronic kidney disease ( CKD ) stage on clinical outcomes patients with newly diagnosed atrial fibrillation ). Methods and Results is a prospective registry 35 countries, including Asia (China, India, Japan, Singapore, South Korea, Thailand). Consecutive enrolled (2013–2016) were classified no, mild, or moderate‐to‐severe , based National Kidney Foundation's...
To provide an overview of the practice patterns advanced nurses and to explore their perceptions role in Singapore.Role expansion is increasingly popular healthcare systems. However, remain variable, thereby introducing ambiguity. Uncertainty revolves around how perceive practice, competency readiness for expansion.A nationwide survey was conducted Singapore. Statistical analyses closed-ended responses content analysis open-ended were undertaken.A total 87 participants surveyed (42.8%...
Current atrial fibrillation (AF) guidelines discourage antiplatelet (AP) monotherapy as alternative to anticoagulants (ACs). Why AP only is still used largely unknown.Factors associated with prescription were analysed in GARFIELD-AF, a registry of patients newly diagnosed (≤6 weeks) AF and ≥1 investigator-determined stroke risk factor. We 51 270 from 35 countries enrolled into five sequential cohorts between 2010 2016. Overall, 20.7% received monotherapy, 52.1% AC 14.1% + AC. Most (82.5%)...
Single-ring isolation of the posterior left atrium is feasible, but incidence and mechanisms postprocedural arrhythmias have not been described in detail.The first 100 consecutive patients (58.8+/-11.2 years old, 80 male) who underwent single-ring for atrial fibrillation (66 intermittent, 18 persistent, 16 long-standing persistent) were followed up 9.1+/-4.5 months. Recurrences diagnosed by clinical symptoms Holter monitoring. Patients with recurrences sustained arrhythmia >3 months after...
Background— Late recurrence of atrial fibrillation (AF) after radiofrequency ablation remains significant. Asymptomatic poses a difficult clinical problem as it is associated with an equally increased risk stroke and death compared symptomatic AF events. Meta-analyses reveal that no single preablation patient characteristic efficiently predicts these recurrences. This study aimed to evaluate the prognostic value premature complex (PAC) occurrence regard late ablation. Methods Results— The...
Early atrial arrhythmia following fibrillation (AF) ablation is associated with higher recurrence rates. Few studies explore the impact of early AF (EAF) and tachycardia (EAT) on long-term outcomes. Furthermore, EAF/EAT have not been characterized after wide pulmonary vein isolation. We aimed to characterize EAF EAT its late (LAF) AT (LAT) single ring isolation (SRI). recruited 119 (females 21, age 58 ± 10 years) consecutive patients (paroxysmal 76, persistent 43) undergoing SRI....
Introduction: Previous studies suggest that segmental ostial isolation of the pulmonary veins for treatment patients with persistent and permanent atrial fibrillation is associated a high rate recurrence. Recurrence usually electrical reconnection to left atrium. Methods: We examined efficacy isolating all four using an open irrigated tip ablation catheter multiple procedures, overcome problem in veins. Fifty‐one (59 ± 10 years, 48 male) drug resistant highly symptomatic or had their...
The current physician-centric model of care is not sustainable for the rising tide atrial fibrillation. integrated has been recommended managing This study aims to provide a preliminary evaluation effectiveness Nurse-led Integrated Chronic E-enhanced Atrial Fibrillation (NICE-AF) clinic in community. NICE-AF was led by an advanced practice nurse (APN) who collaborated with family physician. embodied and shifted from hospital-based, care. Regular patient education, supplemented specially...
The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which providing important information on baseline characteristics, treatment patterns, and 1-year outcomes patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian recruited this registry. A total of 52,014 AF were enrolled globally; these, 1388 26 sites within India (2012–2016). In India, mean age was 65.8...
To explore registered nurses' perceptions towards the role of advanced practice nurses and to examine interests in becoming nurses.Globally, development implementation have been deemed propitious. Advanced are recruited developed from current pool nurses. Empirical research is needed inform on ensuring sustainability nurse workforce through recruitment population nurses.A nationwide cross-sectional online survey was conducted Singapore. Registered all public health care institutions were...
High‐Resolution Thermal Mapping of RF Ablation Lesions Background Radiofrequency (RF) ablation causes thermal mediated irreversible myocardial necrosis. This study aimed to (i) characterize the characteristics lesions with high spatial resolution using a thermochromic liquid crystal (TLC) phantom; and (ii) compare in vivo vitro lesions. Methods Results The phantom was constructed from vertical sheet TLC film, color change between 50 °C (red) 78 (black), embedded within gel matrix, impedance...