A5033377615- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Acute Ischemic Stroke Management
- Health Systems, Economic Evaluations, Quality of Life
- Global Cancer Incidence and Screening
- Antiplatelet Therapy and Cardiovascular Diseases
- Multiple and Secondary Primary Cancers
- HIV/AIDS Research and Interventions
- Colorectal Cancer Screening and Detection
- HIV-related health complications and treatments
- COVID-19 Clinical Research Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Pharmaceutical Economics and Policy
- Cancer Risks and Factors
- HIV/AIDS drug development and treatment
- Vitamin K Research Studies
- Viral-associated cancers and disorders
- BRCA gene mutations in cancer
- COVID-19 and healthcare impacts
- Heart Failure Treatment and Management
- Advanced Causal Inference Techniques
- Health Promotion and Cardiovascular Prevention
- Reproductive System and Pregnancy
- Thyroid Cancer Diagnosis and Treatment
Thrombosis Research Institute
2018-2025
Centro di Riferimento Oncologico
2014-2020
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2019
BACKGROUND: Current clinical decision tools for assessing bleeding risk in individuals with atrial fibrillation (AF) have limited performance and were developed treated warfarin. This study develops validates a score to personalize estimates of taking direct-acting oral anticoagulants (DOACs). METHODS: Among dabigatran 150 mg twice per day from 44 countries 951 centers this secondary analysis the RE-LY trial (Randomized Evaluation Long-Term Anticoagulation Therapy), was determine comparative...
The recommended doses for direct oral anticoagulants (DOACs) to prevent stroke and systemic embolism (SE) in patients with atrial fibrillation (AF) are described specific regulatory authority approvals. impact of DOAC dosing, according the guidance on all-cause mortality, stroke/SE, major bleeding, was assessed at 2-year follow-up newly diagnosed AF. Of a total 34,926 enrolled (2013 2016) prospective GARFIELD-AF (Global Anticoagulant Registry FIELD-AF), 10,426 received DOAC. majority (72.9%)...
Background: Atrial fibrillation is associated with increased risks of death, stroke/systemic embolism, and bleeding (incurred by antithrombotic therapy), which may occur early after diagnosis. Methods: We assessed the risk events (death, major bleeding) over 12 months their relation to time diagnosis atrial in 52 014 patients prospectively enrolled GARFIELD-AF registry (Global Anticoagulant Registry FIELD–Atrial Fibrillation) between March 2010 August 2016. Results: Over months, 2140 died...
Abstract Aims Deciding to stop or continue anticoagulation for venous thromboembolism (VTE) after initial treatment is challenging, as individual risks of recurrence and bleeding are heterogeneous. The present study aimed develop externally validate models predicting 5-year in patients with VTE without cancer who completed at least 3 months treatment, which can be used estimate absolute benefits harms extended anticoagulation. Methods results Competing risk-adjusted were derived predict...
Background Differences in the clinical outcomes and level of risk among Asian versus non-Asian patients with atrial fibrillation (AF) have been sparsely investigated. Objective To provide a contemporary prospective comparison for newly diagnosed AF, between regions. Methods Six countries (China, Japan, India, Singapore, South Korea Thailand) 29 outside Asia participated Global Anticoagulant Registry FIELD-AF (GARFIELD-AF) study. Newly enrolled 2010 2016, were followed up for≥2 years. The...
BackgroundPersons living after a cancer diagnosis represent 4% of the whole population in high-income countries. The aim study was to provide estimates indicators long-term survival and cure for 26 types, presently lacking.Patients methodsData on 818 902 Italian patients diagnosed at age 15–74 years 1985–2005 were included. Proportions with same death rates general (cure fractions) those prevalent who not risk dying as result prevalence) calculated, using validated mixture models, by type,...
A higher frequency of early onset female breast cancers (BC) has been observed in low/middle income countries than high countries. We quantified the role population ageing to this pattern using data from all population-based cancer registries (CRs) worldwide. Patients' median age at BC and that general were extracted for CRs listed volumes VI (1983-1987 years) through XI (2008-2012 Cancer Incidence Five Continents. Their association was assessed cross-sectional level by linear regression...
A principal aim of the Global Anticoagulant Registry in FIELD-Atrial Fibrillation (GARFIELD-AF) was to document changes treatment practice for patients with newly diagnosed atrial fibrillation during an era when non–vitamin K antagonist oral anticoagulants (NOACs) were becoming more widely adopted. In these analyses, key factors which determined choice between NOACs and vitamin antagonists (VKAs) are explored. Logistic least absolute shrinkage selection operator regression predictors NOAC...
In atrial fibrillation (AF), lower risks of death and bleeding with non-vitamin-K oral anticoagulants (NOACs) were reported in meta-analyses controlled trials, but whether these findings hold true real-world practice remains uncertain. Risks assessed 52 032 patients newly diagnosed AF enrolled GARFIELD-AF (Global Anticoagulant Registry the FIELD-Atrial Fibrillation), a worldwide prospective registry. Baseline treatment was vitamin K antagonists (VKAs) or without antiplatelet (AP) agents (VKA...
BackgroundAsymptomatic atrial fibrillation is often detected incidentally. Prognosis and optimal therapy for asymptomatic compared with symptomatic uncertain. This study compares clinical characteristics, treatment, 2-year outcomes of presentations.MethodsGlobal Anticoagulant Registry in the Field-Atrial Fibrillation (GARFIELD-AF) a global, prospective, observational newly diagnosed ≥1 stroke risk factors (http://www.clinicaltrials.gov, unique identifier: NCT01090362). Patients were...
Estimates of cancer prevalence are widely based on limited duration, often including patients living after a diagnosis made in the previous 5 years and less frequently complete (i.e., all regardless time elapsed since diagnosis). This study aims to provide estimates Italy by sex, age, for cancers combined, selected types. Projections were up 2020, overall diagnosis.
Non-AIDS-defining cancers (non-ADCs) have become the leading non-AIDS-related cause of death among people with HIV/AIDS. We aimed to quantify excess risk cancer-related deaths Italian AIDS (PWA), as compared without (non-PWA).A nationwide, population-based, retrospective cohort study was carried out 5285 PWA, aged 15-74 years, diagnosed between 2006 and 2011. Date multiple-cause-of-death data were retrieved up December Excess mortality, non-PWA, estimated using sex- age-standardized...
Incidence rates of various cancers are increasing in Arab countries and expected to reach those industrialized ones few decades. This paper aimed describe the incidence most common cancers--and/or cancer preventable through modifiable behaviors--recorded province Setif, Algeria from 1986 2010.Cancer diagnoses for 1986-2010 period were provided by population-based Cancer Registry disentangled site, morphology, age (quinquennia), sex, calendar period. The corresponding population was obtained...
To determine whether the Global Anticoagulant Registry in FIELD-Atrial Fibrillation (GARFIELD-AF) integrated risk tool predicts mortality, non-haemorrhagic stroke/systemic embolism, and major bleeding for up to 2 years after new-onset AF assess how this performs compared with CHA2DS2-VASc HAS-BLED.Potential predictors of events included demographic clinical characteristics, choice treatment, lifestyle factors. A Cox proportional hazards model was identified each outcome by least absolute...
Abstract Aims Heart failure (HF) and atrial fibrillation (AF) may coexist influence each other. However, characteristics, anticoagulant treatment, outcomes of contemporary AF patients with concurrent HF are ill‐defined. This study analyses 2 year in newly diagnosed Global Anticoagulant Registry the FIELD‐Atrial Fibrillation (GARFIELD‐AF) vs. without HF. Methods results GARFIELD‐AF is world's largest observational patient study. At enrolment, 11 758 52 072 (22.6%) had HF; 76.3% were New York...
Aims This study aimed to determine the robustness, reproducibility and representativeness of landmark Apixaban for Reduction in Stroke Other Thromboembolic Events Atrial Fibrillation (AF) (ARISTOTLE) Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism Prevention Embolism Trial AF (ROCKET AF) randomised trials through replication an observational patient registry. Methods results Patients from Global Anticoagulant Registry FIELD (GARFIELD)-AF registry...
Guidelines do not recommend to take pattern of atrial fibrillation (AF) into account for the indication anticoagulation (AC). We assessed AF and risk cardiovascular events during 2-years follow-up.We categorized as paroxysmal, persistent, or permanent in 29 181 patients enrolled (2010-15) Global Anticoagulant Registry In FIELD (GARFIELD-AF). used multivariable Cox regression assess risks stroke/systemic embolism (SE) death across patterns AF, whether this changed with AC on outcomes. Atrial...
Objectives This study evaluated the comparative effectiveness of vitamin K antagonists (VKAs), direct thrombin inhibitors (DTIs) and factor Xa (FXaI) in patients with atrial fibrillation (AF) at risk stroke everyday practice. Methods Data from AF Congestive heart failure, Hypertension, Age 75 years, Diabetes mellitus, prior Stroke, TIA, or thromboembolism, Vascular disease, 65-74 Sex category (CHA 2 DS -VASc) score ≥2 (excluding gender) Global Anticoagulant Registry FIELD–Atrial Fibrillation...
Investigate real-world outcomes of early rhythm versus rate control in patients with recent onset atrial fibrillation. The Global Anticoagulant Registry the FIELD-AF (GARFIELD-AF) is an international multi-centre, non-interventional prospective registry newly diagnosed (≤6 weeks' duration) fibrillation at risk for stroke. Patients were stratified according to treatment initiated baseline (≤48 days post enrolment), and outcome risks evaluated by overlap propensity weighted Cox...
Multiple cause-of-death (MCOD) data allow analyzing the contribution to mortality of conditions reported on death certificate that are not selected as underlying cause death. Using MCOD data, this study aimed fully describe cause-specific people with AIDS (PWA) compared without AIDS.We conducted a nationwide investigation based certificates 2,515 Italian PWA and 123,224 who had died between 2006 2010. The most frequently associated mortality, AIDS, were identified using an age-standardized...
Cancer is one of the major public health problems in Algeria.In last 25 years, a significant increase incidence types cancers has been observed both sexes.Moreover, 5-year survival rate low for severe tumors due to difficulty access cancer care and an incomplete framework.Cancer Registry Setif, Algeria, recording incidence, mortality, since 1986 collaboration with International Agency Research on (IARC) Lyon.Cancer Setif being source information planning corresponding surveillance National...