A5075708076- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Atrial Fibrillation Management and Outcomes
- Diagnosis and Treatment of Venous Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Acute Myocardial Infarction Research
- Blood Pressure and Hypertension Studies
- Central Venous Catheters and Hemodialysis
- Climate Change and Health Impacts
- Blood properties and coagulation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Genetic Associations and Epidemiology
- Acute Ischemic Stroke Management
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Chemotherapy-induced cardiotoxicity and mitigation
- Complement system in diseases
- Peripheral Artery Disease Management
- Platelet Disorders and Treatments
- Extracellular vesicles in disease
- Antiplatelet Therapy and Cardiovascular Diseases
- Hemophilia Treatment and Research
- Health Systems, Economic Evaluations, Quality of Life
- Fatty Acid Research and Health
- Circular RNAs in diseases
UiT The Arctic University of Norway
2016-2025
University Hospital of North Norway
2016-2025
University of Miyazaki Hospital
2023
University of Vermont
2012-2023
Østfold Hospital Trust
2023
Creative Electron (United States)
2018
Leiden University Medical Center
2012-2017
Thrombosis Research Institute
2015-2017
University of California, San Diego
2016
Rady Children's Hospital-San Diego
2016
Hematocrit above the normal range for population, such as in primary or secondary erythrocytosis, predisposes to both arterial and venous thrombosis. However, little is known about association between hematocrit risk of thromboembolism a general population.Hematocrit related hematologic variables hemoglobin, red blood cell count, mean corpuscular volume, baseline characteristics were measured 26,108 subjects, who participated Tromsø Study 1994-1995. Incident thromboembolic events during...
Genotypes generated in next generation sequencing studies contain errors which can significantly impact the power to detect signals common and rare variant association tests. These genotyping are not explicitly filtered by standard GATK Variant Quality Score Recalibration (VQSR) tool thus remain a source of whole exome (WES) projects that follow GATK's recommended best practices. Therefore, additional data filtering methods required effectively remove these before performing analyses with...
An association between body height and venous thromboembolism (VTE) has been suggested by previous studies including males only. The aim of this prospective cohort study was to investigate the sex-specific impact on risk VTE in a general population. Risk factors, weight, were registered for 26,727 subjects aged 25-96 years who participated Tromsø Study (Norway) 1994-1995. Incident events through September 1, 2007. There 462 during median 12.5 follow-up. Body factor men, but not women....
The relationship between chronic obstructive pulmonary disease (COPD) and risk of venous thromboembolism (VTE) has been scarcely studied in the general population. We aimed to investigate association COPD VTE mortality a population-based cohort. Spirometry was conducted 8646 males females, participating fifth (2001–02) sixth (2007–08) surveys Tromsø Study. Incident events during follow-up were registered from date inclusion December 31, 2011. Cox-regression models with stages confounders as...
Background: Venous thromboembolism (VTE) is a life-threatening vascular event with environmental and genetic determinants. Recent VTE genome-wide association studies (GWAS) meta-analyses involved nearly 30 000 cases identified up to 40 loci associated risk, including not previously suspected play role in hemostasis. The aim of our research was expand discovery new by using cross-ancestry genomic resources. Methods: We present meta-analyzed GWAS results involving 81 669 from studies,...
Plasminogen activator inhibitor-1 (PAI-1), the main inhibitor of fibrinolysis, is frequently elevated in obesity and could potentially mediate risk venous thromboembolism (VTE) obese subjects. However, whether PAI-1 associated with VTE remains uncertain.To investigate association between plasma levels future incident obesity.A population-based nested case-control study, comprising 383 cases 782 age- sex-matched controls, was derived from Tromsø Study cohort. antigen were measured samples...
Abstract Aims Deciding to stop or continue anticoagulation for venous thromboembolism (VTE) after initial treatment is challenging, as individual risks of recurrence and bleeding are heterogeneous. The present study aimed develop externally validate models predicting 5-year in patients with VTE without cancer who completed at least 3 months treatment, which can be used estimate absolute benefits harms extended anticoagulation. Methods results Competing risk-adjusted were derived predict...
Background Red cell distribution width (RDW), a measure of the variability in size circulating erythrocytes, is associated with mortality and adverse outcome selected populations cardiovascular disease. It scarcely known whether RDW incident myocardial infarction (MI). We aimed to investigate was risk first‐ever MI large cohort study participants recruited from general population. Methods Results Baseline characteristics, including RDW, were collected for 25 612 Tromsø Study 1994–1995....
Even though clinical data support a relation between ischemic stroke and venous thromboembolism (VTE), the strength time dependence of association remain to be settled at population level. We therefore aimed investigate VTE in prospective population-based cohort.Participants (n=30 002) were recruited from 3 surveys Tromsø study (conducted 1994-1995, 2001, 2007-2008) followed through 2010. All incident events during follow-up recorded. Cox-regression models with age as scale time-dependent...
Several case-control studies have reported elevated plasma von Willebrand factor (VWF) levels in patients with venous thromboembolism (VTE) compared controls. However, because few investigated the association a prospective design, it is unclear whether VWF risk or consequence of VTE event. Therefore, we aimed to investigate between and VTE, as well perform subgroup analyses deep vein thrombosis (DVT) pulmonary embolism. We established population-based nested study 414 cases 843 age-...