Florian Thibord
A5034544573- Genetic Associations and Epidemiology
- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Cancer-related molecular mechanisms research
- Antiplatelet Therapy and Cardiovascular Diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lipid metabolism and disorders
- Blood properties and coagulation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hemophilia Treatment and Research
- Pharmacology and Obesity Treatment
- Cardiovascular Effects of Exercise
- Atherosclerosis and Cardiovascular Diseases
- Epigenetics and DNA Methylation
- Cardiovascular and exercise physiology
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Health and Disease Prevention
- Diabetes, Cardiovascular Risks, and Lipoproteins
- SARS-CoV-2 and COVID-19 Research
- High Altitude and Hypoxia
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
Framingham Heart Study
2020-2025
National Heart Lung and Blood Institute
2020-2025
Naval Research Laboratory Information Technology Division
2021-2025
Bordeaux Population Health
2018-2024
Université de Bordeaux
2018-2024
Karolinska Institutet
2024
Génétique Médicale & Génomique Fonctionelle
2020-2024
University of Pennsylvania
2022-2023
Framingham State University
2021-2023
Translational Therapeutics (United States)
2022
Host genetic variants influence the susceptibility and severity of several infectious diseases, discovery associations with coronavirus disease 2019 (COVID-19) phenotypes could help to develop new therapeutic strategies decrease its burden. Between May 2020 June 2021, we used COVID-19 data released periodically by UK Biobank performed 65 genome-wide association studies in up 18 releases (n = 18,481 cases 2021), hospitalization 3,260), severe outcomes 1,244), deaths 1,104), stratified sex...
Background: Venous thromboembolism (VTE) is a life-threatening vascular event with environmental and genetic determinants. Recent VTE genome-wide association studies (GWAS) meta-analyses involved nearly 30 000 cases identified up to 40 loci associated risk, including not previously suspected play role in hemostasis. The aim of our research was expand discovery new by using cross-ancestry genomic resources. Methods: We present meta-analyzed GWAS results involving 81 669 from studies,...
MicroRNAs (miRNAs) are small RNA molecules (∼22 nucleotide long) involved in post-transcriptional gene regulation. Advances high-throughput sequencing technologies led to the discovery of isomiRs, which miRNA sequence variants. While many miRNA-seq analysis tools exist, diversity output formats hinders accurate comparisons between and precludes data sharing development common downstream methods.To overcome this situation, we present here a community-based project, Transcriptomic Open Project...
BackgroundMulti‐phenotype analysis of genetically correlated phenotypes can increase the statistical power to detect loci associated with multiple traits, leading discovery novel loci. This is first study date comprehensively analyze shared genetic effects within different hemostatic and between these their disease outcomes.ObjectivesTo discover associations by combining summary data traits events.MethodsSummary statistics from genome wide‐association studies (GWAS) seven (factor VII [FVII],...
ABSTRACT Integrating multi‐omics data may help researchers understand the genetic underpinnings of complex traits and diseases. However, best ways to integrate use them address pressing scientific questions remain a challenge. One important topical problem is how assess aggregate effect multiple genomic types (e.g. genotypes gene expression levels) on phenotype, particularly while accommodating routine issues, such as having related subjects' in analyses. In this paper, we extend an existing...
Abstract Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious short- and long-term complications. In clinical practice, there need for improved plasma biomarker-based tools VTE diagnosis risk prediction. Here we show, using proteomics profiling to screen from patients suspected acute VTE, several case-control studies how Complement Factor H Related 5 protein (CFHR5), regulator of the alternative pathway complement activation, VTE-associated biomarker....
Essentials•Platelet function testing in large populations is rare.•We performed 5 types of platelet tests on 3429 participants the Framingham Heart Study.•Different are unique, and so one cannot be substituted for another.•Sex, age, aspirin use significantly affect results, care must taken interpreting reference ranges.AbstractBackgroundAssessment key diagnosing bleeding disorders evaluating antiplatelet drug efficacy. However, there a prevailing "one-size-fits-all" approach interpretation...
Background and Purpose- Arterial vasospasm is a well-known delayed complication of aneurysmal subarachnoid hemorrhage (aSAH). However, no validated biomarker exists to help clinicians discriminating patients with aSAH who will develop (VSP+) identifying those then deserve aggressive preventive therapy. We hypothesized that whole-blood miRNAs could be source candidate biomarkers for vasospasm. Methods- Using next-generation sequencing approach, we performed miRNA profiling between...
Depression is an independent risk factor of cardiovascular disease morbidity. Serotonin a key neurotransmitter in depressive pathology, contained within platelets, and weak activator platelets. Our study assessed the link between platelet reactivity traits, depression, antidepressant (AD) use large population sample. was conducted Framingham Heart Study (n = 3,140), AD 563) aspirin 681) were noted. measured using Center for Epidemiological Studies-Depression (CES-D) survey. Platelet traits...
Abstract Platelets play a key role in thrombosis and hemostasis. Platelet count (PLT) mean platelet volume (MPV) are highly heritable quantitative traits, with hundreds of genetic signals previously identified, mostly European ancestry populations. We here utilize whole genome sequencing (WGS) from NHLBI’s Trans-Omics for Precision Medicine initiative (TOPMed) large multi-ethnic sample to further explore common rare variation contributing PLT (n = 61 200) MPV 23 485). identified replicated...
Abstract Many individual genetic risk loci have been associated with multiple common human diseases. However, the molecular basis of this pleiotropy often remains unclear. We present an integrative approach to reveal mechanism underlying PROCR locus, lower coronary artery disease (CAD) but higher venous thromboembolism (VTE) risk. identify -p.Ser219Gly as likely causal variant at locus and protein C a factor. Using analyses, recall-by-genotype in vitro experimentation, we demonstrate that...
Abstract Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality, with large disparities in incidence rates between Black White Americans. Polygenic risk scores (PRSs) limited variants discovered genome-wide association studies European-ancestry samples can identify individuals at high of VTE. However, there evidence on whether high-dimensional PRS constructed using more sophisticated methods diverse training data enhance the predictive ability their utility...
Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality, with large disparities in incidence rates between Black White Americans. Polygenic risk scores (PRSs) limited variants discovered genome-wide association studies European-ancestry samples can identify individuals at high of VTE. However, there evidence on whether high-dimensional PRS constructed using more sophisticated methods diverse training data enhance the predictive ability their utility across...
Our prior genome-wide association study of thrombin-induced platelet aggregation identified a G protein-coupled receptor kinase 5 (GRK5) noncoding variant (rs10886430-G) that is strongly associated with increased reactivity to thrombin. This predisposes risk stroke, pulmonary embolism, and venous thromboembolism.
Abstract Background Alcohol consumption is linked to decreased platelet function. Whether this link dependent on sex or type of beverage remains unclear. Methods Cross-sectional data were obtained from the Framingham Heart Study (N = 3427). was assessed by using standardized medical history and Harvard semi-quantitative food frequency questionnaires. Five bioassays measured 120 reactivity traits across agonists in whole-blood platelet-rich plasma samples. Linear mixed-effects models adjusted...
MicroRNAs (miRNAs) are small regulatory RNAs participating to several biological processes and known be involved in various pathologies. Measurable body fluids, miRNAs have been proposed serve as efficient biomarkers for diseases and/or associated traits. Here, we performed a next-generation-sequencing based profiling of plasma 344 patients with venous thrombosis (VT) assessed the association miRNA levels haemostatic traits risk VT recurrence. Among most significant findings, detected an...
SUMMARY Genome wide association study (GWAS) results for Venous Thromboembolism (VTE) across 9 international cohorts of the Global Biobank Meta-analysis Initiative (GBMI), with representation six ancestry groups (cases=27,987, controls=1,035,290), were combined using inverse-variance weighted meta-analysis. This multi-ancestry GWAS resulted in 38 genome-wide significant loci, which are potentially novel. For each autosomal locus we performed gene prioritization seven independent, yet...
Next-generation sequencing is an increasingly popular and efficient approach to characterize the full set of microRNAs (miRNAs) present in human biosamples. MiRNAs' detection quantification still remain a challenge as they can undergo different posttranscriptional modifications might harbor genetic variations (polymiRs) that may impact on alignment step. We novel algorithm, OPTIMIR, incorporates biological knowledge miRNA editing genome-wide genotype data available processed samples improve...
Arterial tonometry and vascular calcification measures are useful in cardiovascular disease (CVD) risk assessment. Prior studies found associations between measures, arterial calcium, CVD risk. Activated platelets release angiopoietin-1 other factors, which may connect structure platelet function. We analyzed tonometry, function, aortic, thoracic coronary abdominal aorta diameters measured the Framingham Heart Study Gen3/NOS/OMNI-2 cohorts (n = 3,429, 53.7% women, mean age 54.4 years ±9.3)....