Anni Malmberg
A5000286996- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Assisted Reproductive Technology and Twin Pregnancy
- Genetic Associations and Epidemiology
- Neonatal Respiratory Health Research
- Childhood Cancer Survivors' Quality of Life
- Adolescent and Pediatric Healthcare
- Maternal Mental Health During Pregnancy and Postpartum
- Health, Environment, Cognitive Aging
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- Health, psychology, and well-being
- Family Support in Illness
- Blood properties and coagulation
- Sleep and related disorders
- Health disparities and outcomes
- Genetic Mapping and Diversity in Plants and Animals
- Child Nutrition and Feeding Issues
- Pancreatic function and diabetes
- Congenital Diaphragmatic Hernia Studies
- Pregnancy and preeclampsia studies
- Autism Spectrum Disorder Research
- Child Development and Digital Technology
- Breastfeeding Practices and Influences
- Child and Adolescent Psychosocial and Emotional Development
University of Helsinki
2020-2024
Helsinki Art Museum
2022
Background Social isolation and loneliness have been associated with increased risk of dementia, but it is not known whether this modified or confounded by genetic dementia. Methods We used the prospective UK Biobank study 155 070 participants (mean age 64.1 years), including self-reported social loneliness. Genetic was indicated using polygenic score for Alzheimer’s disease incident dementia ascertained electronic health records. Results Overall, 8.6% reported that they were socially...
Gestational age is a useful proxy for assessing developmental maturity, but correct estimation of gestational difficult using clinical measures. DNA methylation at birth has proven to be an accurate predictor age. Previous predictors epigenetic were based on data from the Illumina HumanMethylation 27 K or 450 array, which have subsequently been replaced by MethylationEPIC 850 array (EPIC). Our aims here build clock specific EPIC and evaluate its precision accuracy embryo transfer date...
Maternal depression and anxiety during pregnancy may enhance fetal exposure to glucocorticoids (GCs) harm neurodevelopment. We tested whether a novel cross-tissue polyepigenetic biomarker indicative of in utero GC is associated with mental behavioral disorders their severity children, possibly mediating the associations between maternal prenatal depressive symptoms these child outcomes. Children (n = 814) from Prediction Prevention Preeclampsia Intrauterine Growth Restriction (PREDO) study...
Abstract Background Prenatal inflammation has been proposed as an important mediating factor in several adverse pregnancy outcomes. C-reactive protein (CRP) is inflammatory cytokine easily measured blood. It clinical value due to its reliability a biomarker for systemic and can indicate cellular injury disease severity. Elevated levels of CRP adulthood are associated with alterations DNA methylation. However, no studies have prospectively investigated the relationship between maternal...
Autism spectrum disorder (ASD), attention-deficit/hyperactivity (ADHD), and schizophrenia (SCZ) are highly heritable linked to disruptions in foetal (neuro)development. While epigenetic processes considered an important underlying pathway between genetic susceptibility neurodevelopmental conditions, it is unclear (i) whether these conditions associated with patterns, specifically DNA methylation (DNAm), already at birth; (ii) what extent DNAm patterns unique or shared across (iii) neonatal...
Objective To examine the associations of social isolation and loneliness with incident dementia by level genetic risk. Design Prospective population-based cohort study. Setting participants 155 074 men women (mean age 64.1, SD 2.9 years) from UK Biobank Study, recruited between 2006 2010. Main exposures Self-reported loneliness, polygenic risk score for Alzheimer’s disease low (lowest quintile), intermediate (quintiles 2 to 4), high (highest quintile) categories. outcome Incident all-cause...
Abstract Genetic studies have identified numerous regions associated with plasma fibrinogen levels in Europeans, yet missing heritability and limited inclusion of non-Europeans necessitates further improved power sensitivity. Compared array-based genotyping, whole genome sequencing (WGS) data provides better coverage the representation non-European variants. To understand genetic landscape regulating levels, we meta-analyzed WGS from NHLBI’s Trans-Omics for Precision Medicine (TOPMed)...
Abstract The general psychopathology factor (GPF) has been proposed as a way to capture variance shared between psychiatric symptoms. Despite growing body of evidence showing both genetic and environmental influences on GPF, the biological mechanisms underlying these remain unclear. In current study, we conducted epigenome-wide meta-analyses identify probe- region-level associations DNA methylation (DNAm) with school-age in six cohorts from Pregnancy And Childhood Epigenetics (PACE)...
Despite the substantial heritability of antisocial behavior (ASB), specific genetic variants robustly associated with trait have not been identified. The present study by Broad Antisocial Behavior Consortium (BroadABC) meta-analyzed data from 25 discovery samples (N=85,359) and five independent replication (N = 8,058) genotypic broad measures ASB. We identified first significant associations ASB, involving common intronic in forkhead box protein P2 (FOXP2) gene (lead SNP rs12536335, P 6.32 x...