A5025058487- Child and Adolescent Psychosocial and Emotional Development
- Genetic Associations and Epidemiology
- Health, Environment, Cognitive Aging
- Health disparities and outcomes
- Tryptophan and brain disorders
- Cognitive Abilities and Testing
- Epigenetics and DNA Methylation
- Metabolomics and Mass Spectrometry Studies
- Bullying, Victimization, and Aggression
- Diet and metabolism studies
- Air Quality and Health Impacts
- Noise Effects and Management
- Adipose Tissue and Metabolism
- Urban, Neighborhood, and Segregation Studies
- Intergenerational Family Dynamics and Caregiving
- Genetic Mapping and Diversity in Plants and Animals
- Early Childhood Education and Development
- Food Security and Health in Diverse Populations
- Mental Health Research Topics
- Public Health Policies and Education
- Climate Change and Health Impacts
- Birth, Development, and Health
- Delphi Technique in Research
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Personality Disorders and Psychopathology
Institute for Molecular Medicine Finland
2018-2024
University of Helsinki
2018-2024
Finland University
2018
London Metropolitan University
2017
Dalhousie University
2013-2014
Childhood aggression and its resulting consequences inflict a huge burden on affected children, their relatives, teachers, peers society as whole. Aggression during childhood rarely occurs in isolation is correlated with other symptoms of psychopathology. In this paper, we aim to describe improve the understanding co-occurrence forms We focus behavioural emotional problems, including externalising attention problems anxiety–depression. The data were brought together within EU-ACTION...
Global emphasis on enhancing prevention and treatment strategies necessitates an increased understanding of the biological mechanisms psychopathology. Plasma proteomics is a powerful tool that has been applied in context specific mental disorders for biomarker identification. The p-factor, also known as "general psychopathology factor", concept suggesting there common underlying factor contributes to development various forms disorders. It proposed p-factor can be used understand overall...
Depression is a heterogeneous mental health problem affecting millions worldwide, but majority of individuals with depression do not experience relief from initial treatments. Therefore, we need to improve our understanding the biology depression. Metabolomic approaches, especially untargeted ones, can suggest new hypotheses for further exploring biological mechanisms. Using FinnTwin12 cohort, longitudinal Finnish population-based twin data collected in adolescence and young adulthood...
Adolescent mental health problems impose a significant burden. Exploring evolving social environments could enhance comprehension of their impact on health. We aimed to depict the trajectories neighborhood exposome from middle late adolescence and assess intricate relationship between them adolescent Participants (n = 3965) FinnTwin12 cohort with completed questionnaires at age 17were used. Nine measures were assessed. The comprised 28 indicators. Trajectories these indicators ages 12 17...
Instruments for rating socioemotional behavior with a strong theoretical basis, broad coverage of behaviors, and adequate validation are rare. Here, the Multidimensional Peer Nomination Inventory (MPNI) Form SERI (Socio(E]motional Regulation Inventory) was employed in longitudinal population-based sample Finnish twins at age 17 to study: (1) structure self-ratings on self-regulation behavior, (2) construct, criterion, concurrent, predictive validity scales, as well invariance analysis (3)...
Instruments for rating socioemotional behavior with a strong theoretical basis, broad coverage of behaviors, and adequate validation are rare. Here, the Multidimensional Peer Nomination Inventory (MPNI) Form SERI (Socio(E]motional Regulation Inventory) was employed in longitudinal population-based sample Finnish twins at age 17 to study: (1) structure self-ratings on self-regulation behavior, (2) construct, criterion, concurrent, predictive validity scales, as well invariance analysis (3)...
Modestly prevalent in the general population (~ 4%), but highly prison populations (> 40%), diagnosis of antisocial personality disorder (ASPD) involves aggression as one several possible criteria. Using multiple informants, we aimed to determine if aggression, well direct and indirect subtypes, assessed early adolescence (ages 12, 14) predict young adulthood ASPD a population-based sample. data from Finnish longitudinal twin cohort study with psychiatric interviews available at age 22 (N =...
The influence of genetics and environment on the association plasma proteome with body mass index (BMI) changes in BMI remains underexplored, links to other omics these associations remain be investigated. We characterized protein-BMI trajectory adolescents adults how connect layers.
Abstract The exposome represents the totality of environmental effects, but systematic evaluation between it and depressive symptoms is scant. Here we sought to comprehensively identify association with in late adolescence early adulthood determine genetic covariances them. Based on FinnTwin12 cohort (3,025 participants young 4,127 at age 17), exposome-wide study (ExWAS) design was used significant exposures from 12 domains. Bivariate Cholesky twin models were fitted an score symptoms. In...
Aggressive behavior in school is an ongoing concern. The current focus on specific manifestations such as bullying, but the broad and heterogenous. Children spend a substantial amount of time school, their behaviors setting tend to be less well characterized than at home. Because aggression may index multiple behavioral problems, we used three validated instruments assess means, correlations gender differences teacher-rated aggressive with co-occurring externalizing/internalizing problems...
Regular reporting of health inequalities is essential to monitoring progress efforts reduce inequalities. While population became increasingly common, a subpopulation group breakdown each indicator the rarely standard practice. This study reports education-, sex-, and race-related in four outcomes selected 93 counties United States systematic comparable manner. cross-sectional analysis large, publicly available data, 2008, 2009, 2010 Behavioral Risk Factor Surveillance System (BRFSS)...
Context Reporting on health disparities is fundamental for meeting the goal of reducing disparities. One often overlooked challenge determining best way to report those associated with multiple attributes such as income, education, sex, and race/ethnicity. This article proposes an analytical approach summarizing social in health, we demonstrate its empirical application by comparing degrees patterns all fifty states District Columbia (DC). Methods We used 2009 American Community Survey, our...
We investigated the association between perceived occupational noise exposure and depressive symptoms in young Finnish adults whether sensitivity moderates this association. This study was based on an ongoing longitudinal twin study. included those who had been working daily (n = 521) or weekly 245) during past 12 months (mean age 22.4, SD 0.7, 53% female). asked about at 22 assessed using General Behavior Inventory (GBI) 17 22. Noise covariates were used linear regression models. Perceived...
Instruments for rating socioemotional behavior with a strong theoretical basis, broad coverage of behaviors, and that are well-validated rare. Here, the Multidimensional Peer Nomination Inventory (MPNI) Form SERI (Socio(E]motional Regulation Inventory) was employed in longitudinal population-based sample Finnish twins (FinnTwin 12) at age 17 to study: (1) structure self-ratings on self-regulation behavior, (2) concurrent, discriminative, predictive validity scales, (3) genetic environmental...
Human aggression is a complex behaviour, the biological underpinnings of which remain poorly known. To gain insights into biology, we studied relationships with 11 low-molecular-weight metabolites (amino acids, ketone bodies), processed using 1H nuclear magnetic resonance spectroscopy. We used discovery sample young adults and an independent adult replication sample. 725 from population-based Finnish twin cohort born 1983-1987, levels rated in adolescence (ages 12, 14, 17) by multiple raters...
Abstract Living in the same household exposes family members to shared environments and may be reflected estimates of environment twin analyses. The age at separation cotwins a pair marks end such exposure, is commonly self-reported studies. objective study was summarize from residential records use it validate with status third fourth wave data collection FinnTwin12 cohort. Age generated address information, linking Finnish Population information system since birth. Descriptive statistics...
Abstract Global emphasis on enhancing prevention and treatment strategies necessitates increased understanding of biological mechanisms psychopathology. Plasma proteomics is a powerful tool that has been applied in the context specific mental disorders for biomarker identification. The p-factor, also known as “general psychopathology factor”, concept suggesting there common underlying factor contributes to development various forms disorders. It proposed p-factor can be used understand...
Abstract Internalising symptoms in childhood and adolescence are as heritable adult depression anxiety, yet little is known of their molecular basis. This genome-wide association meta-analysis internalising included repeated observations from 64,641 individuals, aged between 3 18. The N-weighted overall (INT ) detected no significant hits showed low SNP heritability (1.66%, 95% confidence intervals 0.84-2.48%, N effective =132,260). Stratified analyses indicated rater-based heterogeneity...
Abstract Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present genome-wide association meta-analysis (GWAMA) childhood AGG, in which all phenotype measures across ages from multiple assessors were included. We analyzed assessments for total 328 935 observations 87 485 children aged between 1.5 and 18 years, while accounting sample overlap. also meta-analyzed within subsets the data – i.e. rater, instrument age. SNP-heritability overall (AGG ) was...