A5044535008- Air Quality and Health Impacts
- Health, Environment, Cognitive Aging
- Climate Change and Health Impacts
- Noise Effects and Management
- Neonatal and fetal brain pathology
- Pesticide Exposure and Toxicity
- Energy and Environment Impacts
- Urban Green Space and Health
- Effects and risks of endocrine disrupting chemicals
- Childhood Cancer Survivors' Quality of Life
- Epigenetics and DNA Methylation
- Urban Transport and Accessibility
- Carcinogens and Genotoxicity Assessment
- Prenatal Substance Exposure Effects
- Birth, Development, and Health
- Vitamin D Research Studies
- Infant Development and Preterm Care
- Health disparities and outcomes
- Sleep and related disorders
- Folate and B Vitamins Research
- Anesthesia and Neurotoxicity Research
- Child Nutrition and Feeding Issues
- Toxic Organic Pollutants Impact
- Genetics and Neurodevelopmental Disorders
- Electrochemical Analysis and Applications
Barcelona Institute for Global Health
2021-2025
Universitat Pompeu Fabra
2021-2025
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2021-2025
Instituto de Salud Carlos III
2021-2025
Comunidad de Madrid
2024
Inserm
2018-2022
Institut de Recherche en Santé, Environnement et Travail
2018-2022
Université de Rennes
2018-2022
École des Hautes Études en Santé Publique
2019-2022
New York University
2022
Air pollution exposure during early-life is associated with altered brain development, but the precise periods of susceptibility are unknown. We aimed to investigate whether there air between conception and preadolescence in relation white matter microstructure volumes at 9-12 years old. used data 3515 children from Generation R Study, a population-based birth cohort Rotterdam, Netherlands (2002-2006). estimated daily levels nitrogen dioxide (NO2), particulate (PM2.5 PM2.5absorbance)...
The urban environment may influence neurodevelopment from conception onwards, but there is no evaluation of the impact multiple groups exposures simultaneously. We investigated association between early-life and cognitive motor function in children. used data 5403 mother–child pairs four population-based birth-cohorts (UK, France, Spain, Greece). estimated thirteen home during pregnancy childhood, including: built environment, natural spaces, air pollution. Verbal, non-verbal, gross motor,...
Prenatal exposure to air pollution, even at low levels, has been associated with negative effects on a child's neuropsychological functioning. The present work aimed investigate the associations between prenatal pollution cognitive, language, and motor function 40 days of age in highly exposed area Spain. From ECLIPSES study population, counted 473 mother-child pairs. Traffic-related levels home addresses during whole pregnancy were estimated including particulate matter (PM) an aerodynamic...
Recent evidence suggests an association of air pollution exposure with brain development, but on white matter microstructure in children is scarce. We investigated how during pregnancy and childhood impacts longitudinal development throughout adolescence. Our study population consisted 4108 participants Generation R, a large population-based birth cohort from Rotterdam, the Netherlands. Residential to 14 pollutants was estimated land-use regression models. Diffusion tensor images were...
Traffic-related exposures, such as air pollution and noise, show long-term associations with brain alterations in children adolescents. The functional connectivity have been studied using static approaches of resting-state magnetic resonance imaging (rs-fMRI) (i.e., average between regions across the scanning session).
Air pollution exposure is associated with impaired neurodevelopment, altered structural brain morphology in children, and neurodegenerative disorders. Differential susceptibility to air may be influenced by genetic features.To evaluate whether the apolipoprotein E (APOE) genotype or polygenic risk score (PRS) for Alzheimer's Disease (AD) modify association between during pregnancy childhood preadolescents.We included 1186 children from Generation R Study. Concentrations of fourteen...
Growing evidence suggests that urban environment may influence cognition and behavior in children, but the underlying pollutant neurobiological mechanisms are unclear. We evaluated association of built natural space indicators during pregnancy childhood with brain white matter microstructure preadolescents, examined potential mediating role air pollution road-traffic noise. used data Generation R Study, a population-based birth cohort Rotterdam, Netherlands (n = 2725; 2002-2006) for primary...
Air pollution exposure during pregnancy and childhood has been linked to executive function impairment in children, however, very few studies have assessed these two periods jointly identify susceptible of exposure. We sought potential susceptibility nitrogen dioxide (NO
Introduction The European Environment Agency estimates that 75% of the population lives in cities. Despite many advantages city life, risks and challenges to health arising from urbanisation need be addressed order tackle growing burden disease inequalities This study, Urban environment health: a cross-sectional multiregional project based on surveys Spain (DAS-EP project), aims investigate complex association between urban environmental exposures (UrbEEs) health. Methods analysis DAS-EP is...
Abstract Context Maternal vitamin D level is an important determinant of pregnancy and child health outcomes. Exposure to air pollution suspected increase the risk deficiency, but evidence scarce. Objective We investigated association between during maternal levels. Methods A total 15 935 pregnant women from 5 birth cohorts in Europe United States were included. Averaged concentrations nitrogen oxides, fine coarse particles, composition particles conception until measurement estimated at...
Lower fine motor performance in childhood has been associated with poorer cognitive development and neurodevelopmental conditions such as autism spectrum disorder, yet, biological underpinnings remain unclear. DNA methylation (DNAm), an essential process for healthy neurodevelopment, is a key molecular system of interest. In this study, we conducted the first epigenome-wide association study neonatal DNAm ability further examined replicability epigenetic markers independent cohort. The...
Pregnant women are ubiquitously exposed to organic solvents, such as glycol ethers. Several studies suggest potential developmental neurotoxicity following exposure ethers with a lack of clarity possible brain mechanisms. We investigated the association between urinary levels during early pregnancy and motor inhibition function their 10- 12-year-old children by behavioral assessment imaging. Exposure was assessed measuring six metabolites in urine (<19 weeks gestation) 73 pregnant PELAGIE...
Glycol ethers are part of organic solvents. They used in industry and at home during manufacturing or usage products such as paints, cleaning agents cosmetics. The specific detection subtle, low-dose effects early-life exposure to these solvents on neuropsychological performance children is a trendy subject investigation. Neuroimaging allows looking into brain function identifying different cerebral connections that may be affected by neurotoxicants. In this paper, we investigated the...
OPS 55: Pesticides and neurological outcomes, Room 412, Floor 4, August 26, 2019, 1:30 PM - 3:00 Organophosphate insecticides (OP) are widely used for agricultural purposes because of their acute toxicity non-persistence. Epidemiological studies suggest a neurotoxicity in children, after exposure at low levels but possible pathways remain unclear. The present study aims investigating effects prenatal to OP on inhibition control 10-12 year-old children assessed by motor task during functional...
<title>Abstract</title> Background The European Environment Agency estimates that 75% of the population lives in cities. Despite many advantages city life, risks and challenges to health arising from urbanization need be addressed tackle growing burden disease inequalities This article presents study protocol <italic>Urban Health: a cross-sectional multiregional project based on Population Health Surveys Spain</italic> (DAS-EP project), aims investigate complex association between urban...