A5082658403- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dermatology and Skin Diseases
- Congenital Diaphragmatic Hernia Studies
- Gestational Diabetes Research and Management
- Breastfeeding Practices and Influences
- Cytomegalovirus and herpesvirus research
- Child Nutrition and Feeding Issues
- Pregnancy and preeclampsia studies
- Delphi Technique in Research
- Respiratory viral infections research
- IL-33, ST2, and ILC Pathways
- Epigenetics and DNA Methylation
- Electrolyte and hormonal disorders
- Gastroesophageal reflux and treatments
- Immune Cell Function and Interaction
- Pregnancy and Medication Impact
- Food Allergy and Anaphylaxis Research
- Neuroendocrine regulation and behavior
- Reproductive tract infections research
- Human-Animal Interaction Studies
- Air Quality and Health Impacts
- Vitamin D Research Studies
Erasmus MC
2017-2025
Erasmus University Rotterdam
2017-2018
The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into as a risk factor for asthma. However, little is known regarding role in incidence. We examined whether early-onset related phenotypes are associated with developing childhood. This study includes 21 130 children born from 1990 to 2008 Denmark, France, Germany, Greece, Italy, Netherlands, Spain, Sweden UK. followed non-obese at 3–4 years age incident up 8 age. Physician-diagnosed...
Infants with less diverse gut microbiota seem to have higher risks of atopic diseases in early life, but any associations at school age are unclear.This study sought examine the diversity, relative abundance, and functional pathways stool school-age children.We performed a cross-sectional within an existing population-based prospective cohort among 1440 children 10 years age. On samples, 16S ribosomal RNA gene sequencing was performed, taxonomic tables were produced. Physician-diagnosed...
Background Early-life respiratory tract infections could affect airway obstruction and increase asthma risk in later life. However, results from previous studies are inconsistent. Objective We examined the associations of early-life with lung function school-aged children. Methods This study among 5197 children born between April 2002 January 2006 was embedded a population-based prospective cohort study. Information on physician-attended upper lower until age 6 years (categorised into ≤ 3...
Epigenetic mechanisms integrate both genetic variability and environmental exposures. However, comprehensive epigenome-wide analysis has not been performed across major childhood allergic phenotypes. We examined the association of DNA methylation in mid-childhood peripheral blood (Illumina HumanMethyl450K) with atopic sensitization, environmental/inhalant food allergen sensitization 739 children two birth cohorts (Project Viva–Boston, Generation R Study–Rotterdam). covariate-adjusted...
Abstract Background New insights into immune cells could contribute to treatment and monitoring of atopic disease. Because nongenetic factors shape the human system, we here studied these in a large cohort with children adjustment for prenatal postnatal confounders. Methods Information on dermatitis, inhalant‐ food‐allergic sensitization, asthma lung function scores was obtained from 855 10‐year‐old within Generation R cohort. 11‐color flow cytometry performed determine CD27 + − IgG , IgE...
Breastfeeding may have immune modulatory effects that influence the development of childhood allergic sensitization and atopic diseases. We aimed to examine associations breastfeeding with sensitization, inhalant or food allergy eczema, whether any association was affected by disease-related modification exposure modified maternal history allergy, asthma.This study among 5828 children performed in a population-based prospective cohort from fetal life onwards. collected information on...
Atopic diseases, including atopic dermatitis (AD), asthma and allergic rhinoconjunctivitis (AR), are common childhood conditions [1-3]. Although studies in open populations (via general population-based surveys) suggest varying prevalence trends, physician-diagnosed rates primary care remain underexplored. Recent literature questions the assumption of an increase disease prevalence, emphasising shifts increased awareness rather than true epidemiological changes [2, 4, 5]. This study examines...
Rationale: Obesity has been implicated as a pathogenic factor in asthma, but the underlying role of general and organ fat is unclear.Objectives: We hypothesized that fat, rather than total mass, increases risk asthma.Methods: In population-based prospective cohort study among 5,421 children aged 10 years, we measured including body mass index by dual-energy X-ray absorptiometry, subcutaneous index, visceral pericardial liver fraction magnetic resonance imaging. Lung function was spirometry....
Eczema phenotypes based on eczema onset and persistence might better identify groups prone to allergic respiratory conditions than a binary definition of eczema. We examined the associations childhood with sensitization, allergy, asthma lung function at school age. This study among 4277 children was embedded in multi-ethnic population-based prospective cohort study. Five (never, early transient, mid-transient, late persistent) parental-reported physician-diagnosed from age 6 months until 10...
Abstract Background Prenatal inflammation has been proposed as an important mediating factor in several adverse pregnancy outcomes. C-reactive protein (CRP) is inflammatory cytokine easily measured blood. It clinical value due to its reliability a biomarker for systemic and can indicate cellular injury disease severity. Elevated levels of CRP adulthood are associated with alterations DNA methylation. However, no studies have prospectively investigated the relationship between maternal...
Vitamin D deficiency in early life might affect the developing lung and immune system, subsequently influence risk of asthma allergy later life.We examined associations 25-hydroxyvitamin concentrations mid-gestation at birth with function, asthma, inhalant allergic sensitization school-age.This study among 4951 children their mothers was embedded a population-based prospective cohort Rotterdam, Netherlands. Maternal venous blood samples umbilical cord were used to determine concentrations....
Fetal growth restriction is associated with higher risks of childhood respiratory morbidity. blood flow adaptations might contribute to these associations. We examined the associations fetal umbilical, cerebral, and pulmonary wheezing patterns, lung function, asthma in childhood.
Although maternal psychological distress during pregnancy is associated with increased risks of respiratory morbidity in preschool children, it unknown whether this association persists into later childhood.To examine the between parental and lung function asthma children school age.This study 4231 was embedded a population-based prospective cohort. Parental assessed by Brief Symptom Inventory 3 years after pregnancy, mothers also at 2 6 months pregnancy. At age 10 years, obtained spirometry...
Abstract Background We aimed to assess which sociodemographic factors are associated with current asthma and indicators of lung function in 10‐year‐old children. Methods analysed data 5237 children (Mean age: 9.7, SD: 0.3) from the Generation R Study (2012‐2016), a population‐based cohort study Netherlands. Indicators included parental educational level, net household income, financial difficulties, employment status child ethnic background. Current (yes/no) was defined as ever...
Abstract Background Airway bacterial carriage might play a role in respiratory disease. We hypothesize that nasal with Staphylococcus aureus or nasopharyngeal Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae predisposes individuals to adverse health. Objective To examine the association of early‐life airway tract infections vice versa, wheezing, lung function, asthma later childhood. Methods collected upper swabs for culturing S aureus, H M influenzae at six...
<b>Background:</b> Preterm birth and lower weight increase the risk of asthma in childhood. The underlying mechanism might be lung function. <b>Aim:</b> To examine association early growth characteristics with childhood function measured by magnetic resolution imaging (MRI) spirometry. <b>Methods:</b> This study was embedded a population-based prospective cohort among 640 children. Gestational age were obtained from hospital or midwife records. At 10 years, inspiratory total capacity (TLC)...
Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infection are common in early childhood. CMV favours a T-helper-1 EBV T-helper-2 cell response, possibly leading to disbalanced T-helper subsequent risk of asthma or atopy.To study the associations with lung function, inhalant allergic sensitization at school age.This among 3546 children was embedded population-based prospective cohort. At age 6 years, serum IgG levels against were measured by ELISA. 10 function spirometry, questionnaire...
Abstract Background An association has been reported between early life Staphylococcus aureus nasal carriage and higher risk of childhood eczema, but it is unclear whether this relationship causal associations with other bacterial species are unclear. Objective To examine the nasopharyngeal eczema phenotypes, direction any identified. Methods Among 996 subjects a population‐based prospective cohort study, swabs for , Streptococcus pneumoniae Moraxella catarrhalis Haemophilus influenzae were...
<b>Background</b> Early-life respiratory tract infections could affect airway obstruction and increase the risk of asthma in later life. <b>Objective</b> We examined associations early-life with lung function children. <b>Methods</b> used individual participant data 154,492 children from 37 birth cohorts to examine upper (URTI) lower (LRTI) by age 6 months, 1, 2, 3, 4 5 years forced expiratory volume 1 second (FEV<sub>1</sub>), vital capacity (FVC) FEV<sub>1</sub>/FVC, flow at 75% FVC...