A5087283726- Birth, Development, and Health
- Ovarian function and disorders
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Contraception
- Reproductive Health and Technologies
- Reproductive Biology and Fertility
- Endometriosis Research and Treatment
- Pregnancy and Medication Impact
- Reproductive System and Pregnancy
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Menstrual Health and Disorders
- Maternal and fetal healthcare
- Effects and risks of endocrine disrupting chemicals
- Nutrition and Health in Aging
- Epigenetics and DNA Methylation
- Cancer Risks and Factors
- Maternal and Perinatal Health Interventions
- Prenatal Screening and Diagnostics
- Bariatric Surgery and Outcomes
- Cardiovascular Issues in Pregnancy
- Sperm and Testicular Function
- Ectopic Pregnancy Diagnosis and Management
University of Pennsylvania
2021-2025
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2016-2025
National Institutes of Health
2015-2025
Cohort (United Kingdom)
2024-2025
Institute for Medical Informatics and Biostatistics
2025
University of Michigan
2023
Office of Extramural Research
2013-2022
Eunice Kennedy Shriver Center
2011-2022
California University of Pennsylvania
2022
University of Utah
2014-2021
<h3>Importance</h3> Dietary supplements marketed for male fertility commonly contain folic acid and zinc based on limited prior evidence improving semen quality. However, no large-scale trial has examined the efficacy of this therapy quality or live birth. <h3>Objective</h3> To determine effect daily supplementation <h3>Design, Setting, Participants</h3> The Folic Acid Zinc Supplementation Trial was a multicenter randomized clinical trial. Couples (n = 2370; men aged ≥18 years women 18-45...
It is common practice in perinatal epidemiology to calculate gestational-age-specific or birth-weight-specific associations between an exposure and a outcome. Gestational age birth weight, for example, might lie on pathway from the This of conditioning potential intermediate has come under critique various reasons. First, if one interested assessing overall effect outcome, it not necessary stratify, indeed, important intermediate. Second, does condition intermediate, try obtain what...
C-reactive protein (CRP) is one of the most commonly used markers acute phase reaction in clinical settings and predictors cardiovascular risk healthy women; however, data on its physiologic regulation premenopausal women are sparse. The objective this study was to evaluate association between endogenous reproductive hormones CRP BioCycle Study (2005–2007). Women aged 18–44 years from western New York were followed prospectively for up 2 menstrual cycles (n = 259). Serum levels CRP,...
What are the pain characteristics among women, with no prior endometriosis diagnosis, undergoing laparoscopy or laparotomy regardless of clinical indication? Women surgically visualized reported highest chronic/cyclic and significantly greater dyspareunia, dysmenorrhea, dyschezia compared women other gynecologic pathology (including uterine fibroids, pelvic adhesions, benign ovarian cysts, neoplasms congenital Müllerian anomalies) a normal pelvis. Prior research has shown that various...
Do uric acid levels across the menstrual cycle show associations with endogenous estradiol (E2) and reproductive hormone concentrations in regularly menstruating women? Mean were highest during follicular phase, inversely associated E2 progesterone, positively FSH. may decrease serum of post-menopausal women; however, interplay between hormones among women has not been elucidated. The BioCycle study was a prospective cohort conducted at University Buffalo research centre from 2005 to 2007,...
Prior studies examining associations between subclinical hypothyroidism and antithyroid antibodies with early pregnancy loss live birth suggest mixed results time to (TTP) has not been studied in this patient population.This study sought examine of prepregnancy TSH concentrations thyroid autoimmunity TTP, loss, among women proven fecundity a history loss.This was prospective cohort from large, randomized controlled trial that took place at four medical centers the United States.Healthy...
Abstract Background Low‐dose aspirin ( LDA ) has been proposed to improve pregnancy outcomes in couples experiencing recurrent loss. However, results from studies of on have inconsistent, perhaps because most evaluated ‐initiated post‐conception. The purpose the Effects Aspirin Gestation and Reproduction EAGeR trial was determine whether preconception‐initiated improves livebirth rates women with one two prior losses. Methods We performed a multicentre, block randomised, double‐blind,...
Background: Stress has been shown to suppress ovulation in experimental models, but its effect on human reproduction at the population level is unclear. Methods: Healthy women (n = 259), aged 18–44 years from Western New York, were followed for 2 menstrual cycles (2005–2007). Women completed daily perceived stress assessments, a 4-item Perceived Scale (PSS-4) up 4 times each cycle, and 14-item PSS baseline. Mixed model analyses used assess effects of log reproductive hormone concentrations...
Pregnancy complications are associated with increased risk of development cardiometabolic diseases and earlier mortality. However, much the previous research has been limited to White pregnant participants. We aimed investigate pregnancy in association total cause-specific mortality a racially diverse cohort evaluate whether associations differ between Black
ABSTRACT Background Postpartum haemorrhage (PPH) is associated with significant short‐term morbidity and mortality. Whether PPH confers long‐term all‐cause mortality risk unknown. Objective To examine the of PPH. Methods The Collaborative Perinatal Project (CPP) Mortality Linkage Study a prospective cohort study pregnant persons (1959–1966) linked vital status from National Death Index Social Security Master File for through 2016. was defined based on documentation within or after 24 hours...
Conflicting findings have been reported regarding the effect of menstrual cycle phase and sex hormones on insulin sensitivity.The aim was to determine pattern resistance over whether variations in explain these patterns.The BioCycle study is a longitudinal that measured at different phases cycle. Participants had up eight visits per cycle; each visit timed using fertility monitors capture sensitive windows hormonal changes.The conducted general community University Buffalo (Buffalo, NY).A...
Menstrual bleeding patterns are considered relevant indicators of reproductive health, though few studies have evaluated among regularly menstruating premenopausal women. The authors self-reported patterns, incidence spotting, and associations with hormones 201 women in the BioCycle Study (2005–2007) 2 consecutive cycles. Bleeding were assessed by using daily questionnaires pictograms. Marginal structural models used to evaluate between endogenous hormone concentrations subsequent total...
Metals can interfere with hormonal functioning by binding at the receptor site and through indirect mechanisms; thus, they may be associated changes in premenopausal women.We examined associations between cadmium, lead, mercury, anovulation patterns of reproductive hormones [estradiol, progesterone, follicle-stimulating hormone (FSH), luteinizing hormone] among 252 women 18-44 years age who were enrolled BioCycle Study Buffalo, New York.Women followed for up to two menstrual cycles, serum...
Associations between menstrual cycle length and chronic diseases are hypothesized to be due differences in underlying hormonal patterns.The aim of the study was evaluate association profile anovulation.We conducted a prospective cohort at University Buffalo from 2005 2007.We recruited 259 healthy, regularly menstruating women aged 18-44 yr.Cycle observed for up two cycles. Serum estradiol, progesterone, LH, FSH were measured eight times per cycles.Women with short cycles (<26 d) had higher...