A5057672552- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Atrial Fibrillation Management and Outcomes
- Reproductive Health and Contraception
- Diagnosis and Treatment of Venous Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hemophilia Treatment and Research
- Genetic Associations and Epidemiology
- Platelet Disorders and Treatments
- Blood properties and coagulation
- Metabolomics and Mass Spectrometry Studies
- Vascular anomalies and interventions
- Hormonal and reproductive studies
- Maternal and fetal healthcare
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Blood groups and transfusion
- Antiplatelet Therapy and Cardiovascular Diseases
- Ovarian function and disorders
- Peripheral Artery Disease Management
- Cancer-related gene regulation
- Cerebral Venous Sinus Thrombosis
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Air Quality and Health Impacts
Leiden University Medical Center
2016-2025
Loyola University Medical Center
2020
Addenbrooke's Hospital
2005-2018
Cambridge University Hospitals NHS Foundation Trust
2008-2018
Unité de recherche sur les maladies cardiovasculaires et métaboliques
2018
Inserm
2018
Sorbonne Université
2018
National Health Service
2018
Fondation pour l’innovation en Cadiométabolisme et Nutrition
2018
Leiden University
2003-2010
<b>Objective</b> To assess the thrombotic risk associated with oral contraceptive use a focus on dose of oestrogen and type progestogen contraceptives available in Netherlands. <b>Design</b> Population based case-control study. <b>Setting</b> Six participating anticoagulation clinics Netherlands (Amersfoort, Amsterdam, The Hague, Leiden, Rotterdam, Utrecht). <b>Participants</b> Premenopausal women <50 years old who were not pregnant, within four weeks postpartum, using hormone excreting...
To assess the risk of venous thrombosis associated with nonoral contraceptives (ie, injectable depot-medroxyprogesterone acetate contraceptives, hormone [levonorgestrel]-releasing intrauterine devices, a contraceptive patch, or implant).Analyses were performed in Multiple Environmental and Genetic Assessment study, large case-control study on factors for thrombosis. For current analyses, we selected premenopausal women, aged 18 to 50 years, who not pregnant nor within 4 weeks postpartum...
Measurement of the thrombin generating potential could provide a method for quantifying composite effect multiple risk factors. This study assessed first as well recurrent venous thrombotic event associated with an increased endogenous (ETP). Analyses were performed in 360 patients and 404 control subjects Leiden Thrombophilia Study. The ETP was measured directly using fluorogenic assay (Thrombinoscope). Individuals ETP, i.e. above 90th percentile (>2109.0 nM x min) had 1.5-fold [95%...
Linda Flinterman and colleagues report on the long-term mortality rate for individuals who have experienced a first venous thrombosis or pulmonary embolism. They describe an ongoing elevated risk of death had embolism as compared to controls, up eight years after event.
Background: Venous thromboembolism (VTE) is a life-threatening vascular event with environmental and genetic determinants. Recent VTE genome-wide association studies (GWAS) meta-analyses involved nearly 30 000 cases identified up to 40 loci associated risk, including not previously suspected play role in hemostasis. The aim of our research was expand discovery new by using cross-ancestry genomic resources. Methods: We present meta-analyzed GWAS results involving 81 669 from studies,...
Summary. Activated protein C (APC) resistance, determined with a thrombin‐generation‐based APC resistance test, may explain risk differences of venous thrombosis in users second‐ and third‐generation oral contraceptives (OC). To clinically validate this we analysed the Leiden thrombophilia case–control study (474 patients first episode deep vein 474 age‐ sex‐matched control subjects). Data for men women were separately. As hormonal status is known to strongly influence sensitivity ratio...
The aim of this study was to investigate (potential) research participants' (a) information preferences with regard receiving biobanks' genetic results, and (b) attitudes towards the duties researchers communicate results. A total group 1,678 analyzed, consisting a sample general Dutch population (N=1,163) patients asthma, rhinitis, thrombosis (N=515) who completed survey including six fictitious results each presented as aggregate individual result, varied for treatability kind disease....