A5022217648- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Ultrasound in Clinical Applications
- Acute Ischemic Stroke Management
- Central Venous Catheters and Hemodialysis
- Blood Coagulation and Thrombosis Mechanisms
- Acute Myocardial Infarction Research
- Diagnosis and Treatment of Venous Diseases
- Radiation Dose and Imaging
- Cardiac Imaging and Diagnostics
- Meta-analysis and systematic reviews
- Patient-Provider Communication in Healthcare
- Peripheral Artery Disease Management
- Health Systems, Economic Evaluations, Quality of Life
- Patient Satisfaction in Healthcare
- Heparin-Induced Thrombocytopenia and Thrombosis
- COVID-19 Clinical Research Studies
- Reliability and Agreement in Measurement
- Hematological disorders and diagnostics
- Social Media in Health Education
- Cardiac Arrhythmias and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Sepsis Diagnosis and Treatment
- Dermatological and COVID-19 studies
- COVID-19 and healthcare impacts
University Medical Center Utrecht
2017-2025
Radboud University Nijmegen
2024
Radboud University Medical Center
2024
University Hospital Heidelberg
2019-2023
Heidelberg University
2019-2023
Utrecht University
2019-2020
Leiden University Medical Center
2003-2019
Université Paris Cité
2019
Centre National de la Recherche Scientifique
2019
Université de Bretagne Occidentale
2019
ContextPrevious studies have evaluated the safety of relatively complex combinations clinical decision rules and diagnostic tests in patients with suspected pulmonary embolism.ObjectiveTo assess effectiveness a simplified algorithm using dichotomized rule, D-dimer testing, computed tomography (CT) embolism.Design, Setting, PatientsProspective cohort study consecutive clinically acute embolism, conducted 12 centers Netherlands from November 2002 through December 2004. The population 3306...
The revised Geneva score is a fully standardized clinical decision rule (CDR) in the diagnostic workup of patients with suspected pulmonary embolism (PE). variables have different weights, which could lead to miscalculations an acute setting. We validated simplified version score.Data from 1049 2 large prospective trials that included PE were used and combined validate score. constructed CDR by attributing 1 point each item original compared accuracy versions receiver operating...
Pulmonary embolism is one of the leading causes maternal death in Western world. Because low specificity and sensitivity d-dimer test, all pregnant women with suspected pulmonary undergo computed tomographic (CT) angiography or ventilation-perfusion scanning, both which involve radiation exposure to mother fetus. Whether a pregnancy-adapted algorithm could be used safely avoid diagnostic imaging unknown.In prospective study involving embolism, we assessed three criteria from YEARS (clinical...
Abstract Aims Deciding to stop or continue anticoagulation for venous thromboembolism (VTE) after initial treatment is challenging, as individual risks of recurrence and bleeding are heterogeneous. The present study aimed develop externally validate models predicting 5-year in patients with VTE without cancer who completed at least 3 months treatment, which can be used estimate absolute benefits harms extended anticoagulation. Methods results Competing risk-adjusted were derived predict...
Bleeding risk is highly relevant for treatment decisions in cancer-associated thrombosis (CAT). Several scores exist, but have never been validated patients with CAT and are not recommended practice. To compare methods of estimating clinically (major nonmajor) bleeding CAT: (1) existing venous thromboembolism, (2) pragmatic classification based on cancer type, (3) new prediction model. In a posthoc analysis the Hokusai VTE Cancer study, randomized trial comparing edoxaban dalteparin CAT,...
Summary High D‐dimer levels are predictors of death in patients with pulmonary embolism (PE), as more proximally located, larger emboli. The direct link between these three has not yet been described. A cohort 674 consecutive confirmed PE was studied. Patients were followed up for 3 months. measured only an unlikely clinical probability ( n = 262). odds ratio (OR) all variables calculated. Multivariate analysis performed to identify independent risk factors mortality. best predictive cut‐off...
Abstract. Objectives. Diagnostic strategies in patients with suspected pulmonary embolism have been extensively studied outpatients; their value hospitalized has not well established. Our aim was to determine the safety and clinical utility of a simple diagnostic strategy embolism. Design. Prospective management study. Setting. Twelve teaching hospitals (five academic, seven general hospitals). Subject. A total 605 clinically All completed Interventions. First decision rule (CDR)‐score...
Objective. To determine the utility of high quantitative D-dimer levels in diagnosis pulmonary embolism. Methods. testing was performed consecutive patients with suspected We included embolism a risk for venous thromboembolism, i.e. hospitalized patients, older than 80 years, malignancy or previous surgery. Presence based on diagnostic management strategy using clinical decision rule (CDR), and computed tomography. Results. A total 1515 were an overall prevalence 21%. The strongly associated...