A5018470042- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Imaging and Diagnostics
- ECG Monitoring and Analysis
- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Cardiomyopathy and Myosin Studies
- Vascular anomalies and interventions
- Ion channel regulation and function
- Cardiac Structural Anomalies and Repair
- Cardiac tumors and thrombi
- RNA and protein synthesis mechanisms
- Coronary Artery Anomalies
- COVID-19 Clinical Research Studies
- Viral Infections and Immunology Research
- Radiation Dose and Imaging
- Protein Tyrosine Phosphatases
- Infective Endocarditis Diagnosis and Management
- Heat shock proteins research
- Botulinum Toxin and Related Neurological Disorders
Sri Jayadeva Institute of Cardiovascular Sciences and Research
2016-2025
Sree Balaji Dental College and Hospital
2024
St. Luke's Hospital
2020
The Royal Melbourne Hospital
1997-2000
The University of Melbourne
1998-2000
Background —Atrial electrical remodeling may be important for the initiation and perpetuation of atrial arrhythmias. Whether paroxysmal flutter (AFL) chronic AFL cause atria has not been conclusively determined. Methods Results —Before radiofrequency ablation AFL, 15 patients in sinus rhythm were evaluated under autonomic blockade. Lateral right (LRA) effective refractory periods (ERPs) at 600 450 ms measured before 1-minute intervals 10 minutes after spontaneous or pace termination a 5- to...
Background —Evidence suggests that an increased incidence of atrial fibrillation occurs in patients undergoing single-chamber ventricular pacing (VVI) when compared with those (AAI) or having dual-chamber atrioventricular (DDD). The mechanism for this is unknown. We hypothesized long-term loss (AV) synchrony leads to electrical remodeling: a potential explanation difference. Methods and Results —The study was prospective, randomized comparison between 18 paced VVI mode 12 DDD 3 months. Under...
Cardiomyopathy (CMP) is a heritable disorder. Over 50% of cases are gene-elusive on clinical gene panel testing. The contribution variants in non-coding DNA elements that result cryptic splicing and regulate expression has not been explored. We analyzed whole-genome sequencing (WGS) data discovery cohort 209 pediatric CMP patients 1953 independent replication genomes exomes. searched for protein-coding variants, predicted to affect the function or genes. Thirty-nine percent harbored...
Cardiac tumors are a rare cause of arrhythmias in clinical practice. They can broad spectrum arrhythmias, from low-grade ectopics to incessant ventricular tachycardias, including sudden cardiac arrest. Both primary and secondary produce but not all arrhythmias. Although fetuses older adults alike, only specific the underlying arrhythmia different age groups. This article reviews various that associated with their presentations, diagnostic features, management.
Background: Primary hypertrophic cardiomyopathy (HCM) is predominantly a genetic disease causing left ventricular hypertrophy in the absence of other cardiac and systemic metabolic diseases. Currently, limited data exists on prevalence clinically actionable gene variants for primary HCM South Asian Indians (SAI), that necessary minimizing disparities interpreting ancestry-specific variants. Objectives: The ClinGen Hereditary Cardiovascular Disorders (HCVD) Gene Curation Expert Panel...
Magnetic resonance imaging (MRI) can be safely performed in patients with magnetic (MR)-conditional pacemaker systems but remains relatively contraindicated non-MR-conditional systems.The purpose of this study was to evaluate the safety MRI without positioning restrictions an MR-conditional and currently a Medtronic CapSureFix Novus 5076 lead(s).The randomized 266 2:1 ratio group (177 patients) or control (89 patients). At 9-12 weeks postimplant, underwent at 1.5 T. Primary end points were...
Incessant focal atrial tachycardia (FAT), if untreated, can lead to ventricular dysfunction and heart failure (tachycardia-induced cardiomyopathy). Drug therapy of FAT is often difficult ineffective. The efficacy ivabradine has not been systematically evaluated in the treatment FAT.The study group consisted patients with incessant (lasting >24 hours) structurally normal hearts. Patients as a consequence were excluded. All antiarrhythmic drugs discontinued at least 5 half-lives before...
Abstract Aims Vasovagal syncope (VVS) is a common cardiovascular dysautonomic disorder that significantly impacts health and quality of life (QoL). Yoga has been shown to have positive influence on autonomics. This study assessed the effectiveness yoga therapy recurrence VVS QoL. Methods results We randomized subjects with recurrent reflex (>3 episodes in past 1 year) head-up tilt test guideline-directed (Group 1) or 2). Patients Group were advised treatment 2 was taught by certified...
There is limited data regarding the demographics and type of cardiac implantable electronic device (CIED) in India. The aim this survey was to define trends CIED implants, which included permanent pacemakers (PM), intracardiac defibrillators (ICD), resynchronization therapy (CRT-P/D) devices initiative Indian Society Electrocardiology Heart Rhythm Society. used, their indications, demographic characteristics, clinical status co-morbidities were collected using a form over period 1 year. 2117...
To define the incidence, presentation, and outcomes of drug-induced Torsades de Pointes (TdP) with intravenous (IV) amiodarone.From January 2014 to August 2016 a total 268 patients received IV amiodarone, 142 for ventricular tachycardia, 104 atrial flutter/fibrillation, 22 incessant tachycardia. A uniform dosing amiodarone yield 1gm/day was used in all patients.Four (M:F 1:3) mean age 51.25+9.17years developed pause dependent TdP degenerating VF, after dose 690+176.63mg, infused over...
Gene variants in adiponectin receptor 1 cause pathological enlarged hearts.