A5048715234- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Cardiac Ischemia and Reperfusion
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Effects of Exercise
- ECG Monitoring and Analysis
- Mechanical Circulatory Support Devices
- COVID-19 Clinical Research Studies
- Congenital Heart Disease Studies
- Ion channel regulation and function
- Parathyroid Disorders and Treatments
- Acute Myocardial Infarction Research
- Electrolyte and hormonal disorders
- Venous Thromboembolism Diagnosis and Management
- Heart Rate Variability and Autonomic Control
Mayo Clinic
2014-2024
Advocate Illinois Masonic Medical Center
2020-2024
Al-Sabah Hospital
2023
Mayo Clinic in Arizona
2008-2022
Advocate Health Care
2022
Weatherford College
2022
WinnMed
2005-2021
Mayo Clinic in Florida
2011-2021
Advocate Heart Institute
2021
Iowa Orthopaedic Center
2019
Voltage-gated sodium channels drive the initial depolarization phase of cardiac action potential and therefore critically determine conduction excitation through heart. In patients, deletions or loss-of-function mutations channel gene, SCN5A , have been associated with a wide range arrhythmias including bradycardia (heart rate slowing), atrioventricular delay, ventricular fibrillation. The pathophysiological basis these clinical conditions is unresolved. Here we show that disruption mouse...
Long‐Term Outcome of AF Ablation. Introduction: Ablation eliminates atrial fibrillation (AF) in studies with 1 year follow‐up, but very late recurrences may compromise long‐term efficacy. In a large cohort, we sought to describe the determinants delayed recurrence after ablation. Methods and Results : Seven hundred seventy‐four patients (428 paroxysmal [PAF, 55%] 346 persistent or longstanding [PersAF, 45%]) underwent wide area circumferential ablation (WACA, 62%) pulmonary vein isolation...
Cardiac amyloidosis (CA) is associated with increased risk of sudden cardiac arrest. Although ICD therapy improves survival in patients cardiomyopathy due to other etiologies, the benefit CA unclear large part limited data on precise mechanism arrest and selection for therapy.The objective was determine amyloidosis.We reviewed all implant indications, procedures, therapies, evaluated at Mayo Clinic between 2000 2009.A total 53 (33 AL, 10 senile, 9 familial, 1 AA) who underwent implantation...
Although the benefit of implantable cardioverter defibrillator (ICD) therapy in patients with hypertrophic cardiomyopathy (HCM) at risk for sudden cardiac arrest is well established, there may be a higher device complications and inappropriate shocks.To determine incidence ICD shocks HCM impact young age implant atrial fibrillation.HCM who underwent implantation between January 1988 December 2005 were included. The frequency complications, including pneumothorax, pericardial effusion,...
Hypertrophic cardiomyopathy (HCM) is often accompanied by atrial fibrillation (AF) due to diastolic dysfunction, elevated left pressure, and enlargement. Although catheter ablation for drug-refractory AF an effective treatment, the efficacy in HCM remains be established.Thirty-three consecutive patients (25 male, age 51 +/- 11 years) with underwent pulmonary vein (PV) isolation (n = 8) or wide area circumferential additional linear 25) AF. Twelve-lead 24-hour ambulating ECGs,...
Background— Obesity is a risk factor for atrial fibrillation and other cardiovascular conditions. Our objective was to determine whether catheter-based ablation effectively treated in obese patients. Methods Results— Five hundred twenty-three consecutive patients with symptomatic, medication-refractory underwent catheter ablation. Patients were grouped by body mass index (lean, <25 kg/m 2 ; overweight, 25 29.9 obese, ≥30 ). Outcome quality of life measured general health survey (Medical...
Ventricular tachycardia and premature ventricular complexes (PVCs) most frequently occur in the context of structural heart disease. However, burden idiopathic arrhythmias (IVA) general population is unknown.We identified incident cases IVA between 2005 2013 from Olmsted County, Minnesota, using Rochester Epidemiology Project database. For PVC cohorts, we included those with frequent (defined as ≥100 PVC/24 hours) symptomatic PVCs. We defined IVA-associated cardiomyopathy a drop ejection...
Removal of an entire cardiovascular implantable electronic device is associated with morbidity and mortality. We sought to establish a risk classification scheme according the outcomes transvenous lead removal in single center, goal using that guide electrophysiology lab versus operating room extraction.Consecutive patients undergoing from January 2001 October 2012 at Mayo Clinic were retrospectively reviewed.A total 1,378 leads removed 652 (age 64 ± 17 years, M 68%) 702 procedures. Mean...
Background— Outflow tract ventricular tachycardia originating above the semilunar valves has been reported in a small number of studies. Discrete potentials great arteries (above valves) have rarely described patients undergoing electrophysiology evaluation and radiofrequency ablation for arrhythmias. The mechanisms these discrete utility such guiding are unknown. Methods Results— Twelve with outflow arrhythmia arterial were studied. clinical characteristics, properties potentials,...
Right ventricular apical (RVA) pacing creates dyssynchrony and may compromise left ejection fraction (LVEF). The impact of RVA in patients who have undergone atrioventricular junction (AVJ) ablation for atrial fibrillation (AF) is unclear. We sought to determine whether after AVJ with AF compromises LVEF the short- or long-term.We studied 286 underwent at our institution between 1990 2002. Patients were stratified into a short-term follow-up group (LVEF reassessed by echocardiography within...