A5034864627- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- Infective Endocarditis Diagnosis and Management
- Diabetes Treatment and Management
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Antimicrobial Resistance in Staphylococcus
- Acute Myocardial Infarction Research
- GDF15 and Related Biomarkers
- Potassium and Related Disorders
- Inflammatory Biomarkers in Disease Prognosis
- Pulmonary Hypertension Research and Treatments
- Advanced MRI Techniques and Applications
- Metabolism, Diabetes, and Cancer
- Neuroendocrine Tumor Research Advances
- Pregnancy and preeclampsia studies
- Gout, Hyperuricemia, Uric Acid
- Birth, Development, and Health
- Cardiovascular Disease and Adiposity
- Cardiovascular Issues in Pregnancy
- Gestational Diabetes Research and Management
- Liver Disease Diagnosis and Treatment
Queen Mary Hospital
2020-2025
University of Hong Kong
2020-2025
University of Hong Kong - Shenzhen Hospital
2020-2025
Chinese University of Hong Kong
2020-2024
Shanxi Medical University
2020-2022
Hong Kong Metropolitan University
2021
Patients with heart failure (HF) have an increased risk of incident cancer. Data relating to the association statin use cancer and cancer-related mortality among patients HF are sparse.Using a previously validated territory-wide clinical information registry, was ascertained all eligible (n = 87 102) from 2003 2015. Inverse probability treatment weighting used balance baseline covariates between nonusers 50 926) users 36 176). Competing regression Cox proportional-hazard models performed...
BackgroundHeart failure (HF) and dementia frequently co-exist with shared pathological mechanisms risk factors. Our study aims to investigate the association between statin therapy risks of its subtypes among patients HF.MethodsThe Hong Kong Clinical Data Analysis Reporting System database was interrogated identify incident HF diagnosis from 2004 2018, using ICD 9/ICD 10 codes. Inverse probability treatment weighting (IPTW) used balance baseline covariates users (N = 54,004) non-users...
The characteristics of infective endocarditis (IE) in Asians are poorly understood. Therefore, we aim to describe the epidemiological trends and clinical features IE Hong Kong.All patients with incident from 2002-2019 a territory-wide database Kong were identified. We studied age- sex-adjusted one-year mortality between 2002 2019 identified significant contributors 1-year all-cause death using attributable fraction. used propensity score inverse treatment weighting study association surgery...
Patients with heart failure (HF) often suffered from concomitant insomnia. Non-benzodiazepine GABA receptor agonists (Z-drugs) are hypnotics commonly used for treating The effect of Z-drugs on the outcomes patients HF is nonetheless sparse. Our study aims to investigate association and risks adverse cardiovascular in population. A total 202 585 (mean age 73.24, 47.8% male) diagnosed between 2001 2020 were identified Hong Kong Clinical Data Analysis Reporting System. Propensity score matching...
Objective Our study explored the association between depressive symptoms and non-fatal cardiovascular disease, as well other significant risk factors for in middle-aged elderly patients with hypertension China. Design Prospective cohort study. Setting Data were sourced from China Health Retirement Longitudinal Study (CHARLS) database over a 9-year period (2011–2020). Participants Middle-aged aged 45 above Outcome measures Non-fatal disease was ascertained based on self-reported,...
Individuals with type 2 diabetes mellitus (DM) have an increased risk of pneumonia and septic shock. Traditional glucose-lowering drugs recently been found to be associated a higher infections. It remains unclear whether sodium-glucose cotransporter inhibitors (SGLT2is), which pleiotropic/anti-inflammatory effects, may reduce the shock in DM.
Heart failure with preserved ejection fraction (HFpEF) continues to be a diagnostic challenge. Cardiac magnetic resonance atrial measurement, feature tracking (CMR-FT), tagging has long been suggested diagnose HFpEF and potentially complement echocardiography especially when is indeterminate. Data supporting the use of CMR measurements, CMR-FT or tagging, are absent. Our aim conduct prospective case-control study assessing accuracy volume/area, CMR-FT, amongst patients suspected having...
Abstract An increased risk of target organ damage (TOD) has been reported in patients with primary aldosteronism (PA). However, there is relatively little related research on the correlation between degree TOD and those without PA newly diagnosed hypertensive patients. The aim this study was to assess association among hypertension. Newly were consecutively recruited from January 2015 June 2020 at University Hong Kong‐Shenzhen Hospital. Patients stratified into PA. Data for left ventricular...
Background Evidence suggests that chronic obstructive pulmonary disease (COPD) is associated with a higher risk of lung carcinoma. Using territory-wide clinical electronic medical records system, we investigated the association between low-dose aspirin use (≤160 mg) among patients COPD and incidence carcinoma corresponding bleeding. Methods findings This retrospective cohort study conducted utilizing Clinical Data Analysis Reporting System (CDARS), database developed by Hong Kong Hospital...
Heart failure (HF) may increase the risk of dementia via shared factors.The authors investigated incidence, types, clinical correlates, and prognostic impact in a population-based cohort patients with index HF.The previously territory-wide database was interrogated to identify eligible HF (N = 202,121) from 1995 2018. Clinical correlates incident their associations all-cause mortality were assessed using multivariable Cox/competing regression models where appropriate.Among total aged ≥18...
OBJECTIVE To evaluate the association between prediabetes and heart failure (HF) of HF with changes in glycemic status. RESEARCH DESIGN AND METHODS Patients newly diagnosed atrial fibrillation (AF) 2015 2018 were divided into three groups (normoglycemia, prediabetes, type 2 diabetes) according to their baseline The primary outcome was incident HF. Fine Gray competing risks model applied, death defined as event. RESULTS Among 17,943 patients AF (mean age 75.5 years, 47% female), 3,711 (20.7%)...
Whether statin use can reduce the risk of heart failure (HF) remains controversial. The present study evaluates association between and HF in patients with atrial fibrillation.
Abstract Background The relationship between adipocyte fatty acid-binding protein (AFABP) and cardiac remodelling has been reported in cross-sectional studies, although with conflicting results. Type 2 diabetes mellitus (T2DM) is associated left ventricular (LV) hypertrophy diastolic dysfunction, as well elevated circulating AFABP levels. Here we investigated prospectively the association longitudinal changes of dysfunction T2DM. Methods Circulating levels were measured 176 T2DM patients...
Prediabetes, which is a precedent of overt diabetes, known risk factor for adverse cardiovascular outcomes. Its impact on outcomes in patients with cancer who are prescribed anthracycline-containing chemotherapy (ACT) uncertain. The objective this study was to evaluate the association prediabetes events ACT.
Background The effect of glycated hemoglobin (HbA 1c ) variability on adverse outcomes in patients with heart failure (HF) is unclear. We aim to investigate the predictive value HbA risks all‐cause death and HF rehospitalization irrespective their diabetic status. Methods Results Using a previously validated territory‐wide clinical data registry, was assessed by average successive (ASV) or SD all measurements after diagnosis. Multivariable Cox proportional hazards models were used estimate...
Background Macrolide maintenance therapy (MMT) has demonstrated notable efficacy in reducing exacerbation patients with bronchiectasis, which is a major risk factor for cardiovascular events. However, comprehensive assessment of the benefits and safety profile MMT this population lacking. Methods This territory-wide cohort study analyzed diagnosed bronchiectasis Hong Kong between 2001 2018. Patients were classified as receivers or macrolide non-receivers based on administration MMT....
COVID-19 can increase the long-term risk of multiorgan dysfunction. Few studies investigated in Asian populations or association between viral load and risk. We aimed to investigate post-discharge rates hospitalization with baseline all patients Hong Kong. This was a population-based cohort study included positive RT-PCR test for SARS-CoV-2 Kong January 1st 2020 August 30th 2020, routinely admitted public health care facilities isolation treatment. Viral Ct values were available 3433 (85%)...
Abstract Aims To investigate the risk of hyperkalaemia in new users sodium–glucose cotransporter 2 (SGLT2) inhibitors vs. dipeptidyl peptidase-4 (DPP-4) among patients with type diabetes mellitus (T2DM). Methods and results Patients T2DM who commenced treatment an SGLT2 or a DPP-4 inhibitor between 2015 2019 were collected. A multivariable Cox proportional hazards analysis was applied to compare central laboratory-determined severe hyperkalaemia, hypokalaemia (serum potassium ≥6.0, ≥5.5,...
Abstract Aim To investigate the interplay of incident chronic kidney disease (CKD) and/or heart failure (HF) and their associations with prognosis in a large, population‐based cohort type 2 diabetes (T2DM). Methods Patients aged ≥18 years new‐onset T2DM, without renal or HF at baseline, were identified from territory‐wide Clinical Data Analysis Reporting System between 2000 2015. followed up until December 31, 2020 for CKD all‐cause mortality. Results Among 102 488 patients (median age 66...