A5037475709- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Acute Ischemic Stroke Management
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Lipoproteins and Cardiovascular Health
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Vitamin D Research Studies
- Cardiovascular Effects of Exercise
- Cardiovascular Health and Disease Prevention
- Cardiac Valve Diseases and Treatments
- Heart rate and cardiovascular health
- Heart Rate Variability and Autonomic Control
- Venous Thromboembolism Diagnosis and Management
- Cardiomyopathy and Myosin Studies
- Cardiac Fibrosis and Remodeling
- Obstructive Sleep Apnea Research
- Cardiac Health and Mental Health
- Cardiac Ischemia and Reperfusion
University of Hong Kong
2015-2024
Queen Mary Hospital
2015-2024
Chinese University of Hong Kong
2014-2022
University of Hong Kong - Shenzhen Hospital
2018-2021
National Taiwan University Hospital
2019
Kyungpook National University Hospital
2019
China Medical University
2019
China Medical University Hospital
2019
Royal Brompton Hospital
2019
Ramathibodi Hospital
2019
Background and Purpose— Little is known about the impact of quality anticoagulation control, as reflected by time in therapeutic range (TTR), on effectiveness safety warfarin therapy Chinese patients with atrial fibrillation. We investigated risks ischemic stroke intracranial hemorrhage (ICH) relation to at various TTRs a real-world cohort fibrillation receiving compared those dabigatran, aspirin, no therapy. Methods— This an observational study. Results— Of 8754 CHA 2 DS -VASc ≥1 (79.5±9.2...
AimsLittle is known about the ischaemic stroke risk and benefit of warfarin therapy for prevention in chronic kidney disease (CKD) patients on peritoneal dialysis (PD) with concomitant atrial fibrillation (AF). Our objective was to determine a 'real-world' cohort PD AF, clinical or harm aspirin warfarin.
The efficacy and safety of warfarin therapy for stroke prevention in atrial fibrillation (AF) depends on the time therapeutic range (TTR). We aimed to assess predictive ability SAMe-TT2R2 score Chinese AF patients warfarin, whose TTR is notoriously poor.This a single-centre retrospective study. Patients with non-valvular diagnosed between 1997 2011 were stratified according score, was calculated using Rosendaal method. power scores good i.e. >70% assessed. included 1,428 (mean age 76.2±8.7...
Dabigatran, an oral direct thrombin inhibitor, possesses several advantages over warfarin that can in principle simplify the management of stroke prevention atrial fibrillation (AF). Nonetheless it remains unclear whether these translate to clinical practice and encourage long-term therapy. The objective was describe dabigatran therapy for AF identify risk factors discontinuation therapy.We studied 467 consecutive Chinese patients (72 ± 11 years, male: 53.8%) with a mean CHA2DS2-VASc score...
Arrhythmogenic Substrate of Ventricular Arrhythmias at the AMC Introduction Catheter ablation ventricular arrhythmia (VA) fibrous aortic mitral continuity (AMC) has been described, yet nature arrhythmogenic substrate remains unknown. Methods Procedural records 528 consecutive patients undergoing VA Mayo Clinic, Rochester, MN, were reviewed. The electrocardiographic and electrophysiologic characteristics with successful analyzed to characterize underlying substrate. Results Of 21 (mean age...
Blockade of the binding between neonatal Fc receptor and IgG-Fc reduces circulating IgG, thus emerges as a potential therapy for IgG-mediated autoimmune conditions. This was double blind, randomized, single ascending dose study to evaluate safety, pharmacokinetics, pharmacodynamics HBM9161 (a fully humanized monoclonal antibody) in healthy Chinese volunteers. Subjects were randomized receive s.c. or placebo 3:1 ratio 3 dosing cohorts (340 mg, 510 680 respectively), then followed up 85 days....
Heart failure with preserved ejection fraction (HFpEF) continues to be a diagnostic challenge. Cardiac magnetic resonance atrial measurement, feature tracking (CMR-FT), tagging has long been suggested diagnose HFpEF and potentially complement echocardiography especially when is indeterminate. Data supporting the use of CMR measurements, CMR-FT or tagging, are absent. Our aim conduct prospective case-control study assessing accuracy volume/area, CMR-FT, amongst patients suspected having...
ABSTRACT Background Existing data on the risk of ischemic stroke in hyperthyroidism‐related atrial fibrillation ( AF ) and impact long‐term anticoagulation these patients, particularly those with self‐limiting , remain inconclusive. Hypothesis Risk is same as nonhyperthyroid counterparts. Methods This was a single‐center observational study 9727 Chinese patients nonvalvular from July 1997 to December 2011. Patients diagnosed concomitantly hyperthyroidism were identified. Primary secondary...
Little is known about the impact of provision handheld point-of-care ultrasound (POCUS) devices on physical examination skills medical students.We describe an educational initiative that comprised a POCUS workshop followed by allocation device to students for use over subsequent 8 weeks. They were encouraged scan patients and correlate their findings. A mobile instant messaging group discussion platform was set provide feedback from instructors. Physical assessed means clinical...
Underutilization of guideline-directed heart failure with reduced ejection fraction (HFrEF) medications contributes to poor outcomes.
Among international cardiologists it is unclear whether equipoise exists regarding the benefit of diagnosing and managing obstructive sleep apnea (OSA) to improve atrial fibrillation (AF) outcomes clinical practice are linked.Between January 2019 June 2020 we distributed a web-based 12-question survey OSA AF management practicing in 16 countries.The United States, Japan, Sweden, Turkey accounted for two-thirds responses. 863 responded; half were general cardiologists, quarter...
Population-based studies have demonstrated differences in intima-media thickness (IMT) measured from the left and right common carotid arteries (CCAs). However, its prognostic implications among patients with established coronary artery disease (CAD) remain unknown. Correlations between CCAs composite end point of cardiac death or nonfatal acute syndrome 149 angiographically confirmed stable CAD were studied. A total 22 had cardiovascular events during 32.1 ± 10.9 months follow-up....
Catheter ablation is an increasingly used and successful treatment choice for right ventricular outflow tract (RVOT) arrhythmias. While the role of endocavitary structures regional morphology inflow atrium as a cause difficulty with are well described, similar issues within RVOT not understood. It also commonly appreciated that one papillary muscles located proximal RVOT. We report 3 patients in which arrhythmia was targeted ablated conus muscle. The anatomic features, potential fascicular...
Whether PR prolongation independently predicts new-onset ischemic events of myocardial infarction and stroke was unclear. Underlying pathophysiological mechanisms leading to adverse cardiovascular were poorly understood. We investigated the role in pathophysiologically-related underlying mechanisms.We prospectively 597 high-risk outpatients (mean age 66 ± 11 yrs.; male 67%; coronary disease 55%, 22%, diabetes 52%) for stroke, (MI), congestive heart failure (CHF), death. Vascular phenotype...
Outflow tract ventricular arrhythmia (OTVA) can be complicated to target for ablation when originating from either the periaortic or pulmonary valve (PV) region. Both sites may present with a small R wave in lead V1. However, utility of I distinguishing these locations is unknown.Thirty-six consecutive patients (mean age 41 ± 14 years, 13 male) underwent catheter OTVA. OTVA origin was determined intracardiac electrogram tracings and electroanatomic maps. Observers blinded results measured...