A5035254232- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- MicroRNA in disease regulation
- Cardiomyopathy and Myosin Studies
- Ion channel regulation and function
- Sports injuries and prevention
- Circular RNAs in diseases
- Acute Myocardial Infarction Research
- Heart Rate Variability and Autonomic Control
- Antiplatelet Therapy and Cardiovascular Diseases
- Numerical methods for differential equations
- Cardiac Health and Mental Health
- Receptor Mechanisms and Signaling
- Cardiovascular Function and Risk Factors
- Matrix Theory and Algorithms
- Neuroscience and Neural Engineering
- Ion Channels and Receptors
- Macrophage Migration Inhibitory Factor
- Cardiovascular Health and Risk Factors
- Blood Pressure and Hypertension Studies
- Renin-Angiotensin System Studies
Guangdong Provincial People's Hospital
1999-2025
Guangdong Academy of Medical Sciences
2016-2025
Southern Medical University
2023-2025
Guangdong General Hospital
2014-2024
South China University of Technology
2017-2024
Northeast Normal University
2024
Chinese Medical Association
2024
Chongqing University of Posts and Telecommunications
2022
Shanghai East Hospital
2022
Jiangxi Provincial People's Hospital
2022
Abstract Circular RNAs (circRNAs) participate in regulating gene expression diverse biological and pathological processes. The present study aimed to investigate the mechanism underlying modulation of circRNA_000203 on expressions fibrosis-associated genes cardiac fibroblasts. CircRNA_000203 was shown upregulated diabetic mouse myocardium Ang-II-induced Enforced-expression could increase Col1a2, Col3a1 α-SMA RNA pull-down RT-qPCR assay indicated that specifically sponge miR-26b-5p. Dual...
Objective To determine AF prevalence and gaps in atrial fibrillation (AF) awareness management China. Methods We conducted a community-based survey of 47 841 adults (age ≥45 years) seven geographic regions China between 2014 2016. Participants underwent structured questionnaire, standard 12-lead ECG, physical examination blood sampling. prevalence, defined by either ECG detection or self-report, was estimated according to sampling weights, non-response age sex distribution the population....
Despite improvements in diagnostic and therapeutic interventions to combat cardiovascular disease (CVD) recent decades, there are significant ongoing access gaps sex disparities prevention that have not been adequately quantified China. A representative, cross-sectional, community-based survey of adults (aged ≥45 years) was conducted 7 geographic regions China between 2014 2016. Logistic regression models were used determine differences primary secondary CVD prevention, any interaction by...
The molecular mechanisms underlying anthracyclines-induced cardiotoxicity have not been well elucidated. MiRNAs were revealed dysregulated in the myocardium and plasma of rats received Dox treatment. MicroRNA-34a-5p (miR-34a-5p) was verified increased Dox-treated rats, but reversed plus DEX treatments. Human miR-34a-5p also observed patients with diffuse large B-cell lymphoma after 9- 16-week epirubicin therapy. Up-regulation Dox-induced rat cardiomyocyte H9c2 cells. MiR-34a-5p could augment...
The angiotensin-converting enzyme 2-angiotensin-(1–7)-MAS axis (ACE2-Ang-[1–7]-MAS axis) plays an important role in the control of blood pressure. Some previous studies indicated that genetic variants ACE2 may have a potential to influence this axis. Therefore, present study aimed at examining association polymorphisms with circulating and Ang-(1–7) levels patients essential hypertension. Hypertensive who met inclusion criteria were enrolled study. Three Tag single-nucleotide (rs2106809,...
Limited evidence was available on the association of integrated effect multidimensional lifestyle factors with AF incidence among Chinese old adults. This cohort study to examine combined risk older A total 3,253 adults aged 60 years or more from Guangzhou Heart Study were successfully followed up. The healthy score (HLS) established using a weighted approach seven dimensions lifestyles, including diet quality, leisure-time physical activity, sleep alcohol drinking, smoking, mental status,...
The role of microRNA-214-3p (miR-214-3p) in cardiac fibrosis was not well illustrated. present study aimed to investigate the expression and potential target miR-214-3p angiotensin II (Ang-II)-induced fibrosis. MiR-214-3p markedly decreased fibrotic myocardium a mouse Ang-II infusion model, but upregulated Ang-II-treated myofibroblasts. Cardiac shown attenuated Ang-II-infused mice received tail vein injection agomir. Consistently, inhibited Col1a1 Col3a1 myofibroblasts vitro. could bind...
Despite the prognostic importance of mitotic count as one components Bloom-Richardson grade, several studies have found that pathologists' agreement on grade is fairly modest. Collecting a set more than 4,200 candidate figures, we evaluate individual and train computerized system for mitosis detection, comparing its performance to classifications three pathologists. The system's are based evaluation digital micrographs hematoxylin eosin stained breast tissue. On figures where majority...
Desmosomes and gap junctions are situated in the intercalated disks of cardiac muscle maintain integrity mechanical coupling electrical impulse conduction between cells. The desmosomal plakin protein, desmoplakin (DSP), also plays a crucial role stability these interconnected components as well junction connexin proteins. In addition to cell‑to‑cell junctions, other molecules, including voltage‑gated sodium channels (Nav1.5) present disk support contraction muscle. Mutations genes encoding...
Cerebrovascular complications are relatively uncommon, but severe adverse events associated with catheter ablation of atrial fibrillation (AF). This study aimed to investigate the incidence, risk factors, and hospital outcomes cerebrovascular complicating AF ablation.Cerebrovascular occurring during procedure or hospitalization after were assessed. occurred in 9 1946 consecutive procedures (0.46%). Seven patients (0.36% per procedure) diagnosed ischaemic stroke two (0.1% intracranial...
Abstract The role of microRNA-214-3p (miR-214-3p) in cardiac hypertrophy was not well illustrated. present study aimed to investigate the expression and potential target miR-214-3p angiotensin II (Ang-II)-induced mouse hypertrophy. In mice with either Ang-II infusion or transverse aortic constriction (TAC) model, markedly decreased hypertrophic myocardium. Down-regulation observed myocardium patients Expression upregulated Ang-II-induced neonatal ventricular cardiomyocytes. Cardiac...
BackgroundAlthough 21 causative mutations have been associated with PRKAG2 syndrome, our understanding of the syndrome remains incomplete. The aim this project is to further investigate its unique genetic background, clinical manifestations, and underlying structural changes.MethodsWe recruited 885 hypertrophic cardiomyopathy (HCM) probands their families internationally. Targeted next-generation sequencing sudden cardiac death (SCD) genes was performed. role identified variants assessed...
Feature selection is an important preprocessing step in data mining and pattern recognition. The neighborhood rough set (NRS) model a widely-used for feature on continuous data. All currently known NRS models are defined distance metric — mostly the euclidean which invalidates scenarios wherein ineffective, example, while considering differing attribute weights. We first introduce concept of space division granular-rectangular, then construct radius our method by describing relationship...
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, significantly impacting patients' quality of life and increasing risk death, stroke, heart failure, dementia. Over past two decades, there have been significant breakthroughs in AF prediction screening, stroke prevention, rhythm control, catheter ablation, integrated management. During this period, scale, quality, experience management China greatly improved, providing a solid foundation for development guidelines...
This study was designed to identify the pathogenic mutation in a Chinese family with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) using whole genome sequencing (WGS).Probands II:1 and II:2 underwent routine examinations for diagnosis. Genomic DNA extracted from peripheral blood of members analyzed WGS. A total 60,285 single-nucleotide polymorphisms (SNP) 13,918 insertions/deletions (InDel) occurring exonic regions genes predisposing cardiomyopathies arrhythmias were...
Abstract Background Cardiac involvement in Danon disease typically manifests as left ventricular hypertrophy (LVH) and preexcitation. This study aimed to identify patients with among LVH concurrent electrocardiographic Methods Electrocardiographic preexcitation was identified 10 of 197 unexplained whom genetic testing performed using next‐generation sequencing. Results Three (3/10, 30%) were found association different mutations the gene lysosome‐associated membrane protein 2 ( LAMP2 )....
Abstract Background The safety and efficacy of superior vena cava (SVC) isolation using second‐generation cryoballoon (CB) ablation remain unknown. Methods A total 26 (3.2%) patients with SVC‐related paroxysmal atrial fibrillation (AF) from a consecutive series 806 who underwent CB were included. Pulmonary vein was initially achieved by ablation. If the SVC trigger determined, electrical performed CB. Results Real‐time potential observed in all patients. Isolation successfully accomplished...