A5029923411- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Venous Thromboembolism Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Health, Environment, Cognitive Aging
- Cardiovascular Effects of Exercise
- Blood Pressure and Hypertension Studies
- Immune Response and Inflammation
- Heart Rate Variability and Autonomic Control
- Cancer-related molecular mechanisms research
- Obstructive Sleep Apnea Research
- Central Venous Catheters and Hemodialysis
- Sulfur Compounds in Biology
- Enhanced Recovery After Surgery
- Cardiovascular and Diving-Related Complications
- Muscle activation and electromyography studies
- Ion channel regulation and function
- Fluid Dynamics and Mixing
- Cardiac tumors and thrombi
- Ultrasound and Hyperthermia Applications
Guangdong Academy of Medical Sciences
2015-2025
Southern Medical University
2023-2025
Guangdong Provincial People's Hospital
2019-2025
Second Hospital of Hebei Medical University
2013-2022
Hebei Medical University
2013-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2021
Guangdong General Hospital
2015-2018
General Hospital of Shenyang Military Region
2014
Background Atrial fibrillation (AF) significantly increases the ischemic stroke risk. However, relationship between age at diagnosis of AF and subsequent risk remains poorly understood. Methods Results We analyzed data from 5 prospective cohorts: ARIC (Atherosclerosis Risk in Communities) study, CHS (Cardiovascular Health Study), CARDIA (Coronary Artery Development Young Adults), MESA (Multi‐Ethnic Study Atherosclerosis), Framingham Heart (including Offspring cohort Third‐Generation...
Abstract Objective Acute lung injury (ALI) increases sepsis morbidity and mortality. LncRNA H19 plays a critical role in sepsis. miR-107 is highly-expressed TGFβ type III receptor (TGFBR3) poorly-expressed sepsis, yet their roles development require further investigation. This study aimed to investigate the mechanism of alleviating sepsis-induced ALI through miR-107/TGFBR3 axis. Methods Mice were intravenously injected with Ad-H19 adenovirus vector or control one week before establishing...
The study sought to evaluate the procedural and biophysical factors related acute pulmonary vein isolation (PVI) guided by real-time (PV) potential recordings.A total of 180 consecutive patients with drug-resistant atrial fibrillation (AF) undergoing CB2 (second-generation version cryoballoon) ablation were enrolled. Real-time monitoring PV potentials was obtained using an inner lumen spiral mapping catheter.Acute achieved in all PVs without touch-up ablation. assessment disconnection...
Abstract Background The safety and efficacy of superior vena cava (SVC) isolation using second‐generation cryoballoon (CB) ablation remain unknown. Methods A total 26 (3.2%) patients with SVC‐related paroxysmal atrial fibrillation (AF) from a consecutive series 806 who underwent CB were included. Pulmonary vein was initially achieved by ablation. If the SVC trigger determined, electrical performed CB. Results Real‐time potential observed in all patients. Isolation successfully accomplished...
Active-fixation pacing leads allow the use of selective sites. We evaluated their long-term performance versus passive-fixation in 199 newly implanted patients (n = 100 active and n 99 passive). Postoperative thresholds group were higher than passive (0.85 ± 0.31 V vs. 0.53 0.21 at baseline, P < 0.001). The fell to 0.72 0.23 5 years with a significant drop one month (0.68 V, 0.003). slightly increased five years. Differences between groups until three (all 0.05). Active impedances generally...
The aim of this study was to investigate the electrophysiological characteristics and long-term outcome patients undergoing substrate-based ablation left posterior fascicular ventricular tachycardia (LPF-VT) guided by targeting fragmented antegrade Purkinje potentials (FAPs) during sinus rhythm.This retrospectively analysed 50 consecutive referred for ablation. Substrate mapping rhythm performed identify FAP that targeted FAPs were recorded in 48 (96%) rhythm. distribution located at...
Right ventricular outflow tract (RVOT) septal pacing is commonly performed under the standard fluoroscopic positions during procedure. The aim of prospective, randomized study was to evaluate accuracy combination and left lateral (LL) views for determination RVOT position compared with alone. We prospectively enrolled patients who had indications implantation a permanent pacemaker. Patients were randomly assigned into two groups based on intraoperative as follows: LL group (three + view) or...
Abstract Introduction The procedural findings and clinical outcome of second‐generation cryoballoon (CB2) ablation in patients with variant pulmonary vein (PV) anatomy have not been fully investigated. Methods A total 424 consecutive who underwent PV isolation CB2 were included. Computed tomographic (CT) scan was performed all before the procedure. study population divided into common PV, accessory nonvariant groups according to CT scan. Procedural between three compared. Results Variant...
Abstract Introduction To assess the predictors of hemoptysis using second‐generation cryoballoon (CB). Methods Thirty patients with after CB ablation and 60 age‐, gender‐, body mass index‐matched controls were recruited. Anatomic parameters obtained from preprocedural cardiac computed tomography (CT). Pulmonary vein isolation was performed 28‐mm balloon single 3‐minute freeze technique. Results Clinical procedural characteristics similar between groups. A shorter distance left superior PV...
Background: The feasibility and safety of left bundle branch pacing (LBBP) in patients with conduction diseases following prosthetic valves (PVs) have not been well described. Methods: Permanent LBBP was attempted PVs. Procedural success intracardiac electrical measurements were recorded at implant. Pacing threshold, complications, echocardiographic data assessed implant follow-up visit. Results: Twenty-two consecutive atrioventricular (AV) disturbances (10 AV nodal block 12 infranodal...
This study describes the electrophysiologic characteristics of para-hisian accessory pathway (AP), outcome different ablation approaches, and safety at sites.A total 120 patients diagnosed as AP were included in this study. The outcomes sites analyzed.In total, 107 APs 13 right anteroseptal (RAS) midseptal (RMS), respectively. significant ECG difference between RAS RMS was lead III, which mainly manifested positive negative delta waves, Catheter trauma to recorded 21 (17.5%) patients....
Abstract Background Radiofrequency (RF) catheter ablation of para‐Hisian accessory pathways (APs) can be challenging due to proximity the conduction system. Methods A total 30 consecutive patients with AP were enrolled for in three centers, 12 (40%) whom had previously failed attempted from inferior vena cava (IVC) approach. Ablation was preferentially performed using a superior approach (SVC) all patients. Results The eliminated SVC 28 (93.3%) In remaining two patients, additional IVC...
Background Electrocardiographic (ECG) characteristics of true right ventricular outflow tract (RVOT) septal pacing have not been clearly demonstrated. Hypothesis We hypothesized that ECG parameters would help operators differentiate RVOT septum from non‐septal septum. Methods analyzed 151 patients who underwent pacemaker implantation with a lead in the RVOT. Transthoracic echocardiographic (TTE) determination sites was applied all after implantation. A 12‐lead recorded during forced pacing....
We aimed to examine the electrocardiographic and electrophysiologic characteristics of anterograde-conducting decremental accessory pathways (DAP) identify surrogate criteria distinguish short atrioventricular (SAV) DAP from atriofascicular (AF) AP long (LAV) DAP.We identified all patients with DAPs analysed characteristics. Distal insertion sites were examined using existing criteria, including V-H interval, ventricular activation at right apex, around tricuspid annulus during antidromic...
Abstract Introduction The “Crosstalk” technique: if pulmonary vein isolation (PVI) of the superior one is not achieved due to a gap in inferior part, it could be done during cryoablation. This maneuver minimizes total energy delivery time and number lesions. We aimed correlate likelihood crosstalk phenomenon with certain anatomic characteristics. Methods A 676 patients undergoing first ablation procedure for paroxysmal or persistent atrial fibrillation (470 first‐generation cryoballoon [CB]...
Focal atrial tachycardias (AT) originating from the left appendage (LAA) constitute a minor part of all ATs. However, successful catheter ablation in these foci remains challenging owing to complexity LAA anatomy, and sometimes even surgical excision or epicardial are required eliminate AT.1,2 Cryoballoon (CB) is safe effective tool achieve pulmonary vein isolation. Recently, second-generation CB (CB2) has been used perform isolation addition during fibrillation (AF) ablation.
Both genetic and environmental factors contribute to the development of ventricular arrhythmias (VAs). However, extent which susceptibility modifies effects air pollutants on risk VAs remains poorly understood.