A5101959725- Acute Myeloid Leukemia Research
- Tuberculosis Research and Epidemiology
- Pregnancy and preeclampsia studies
- Cardiomyopathy and Myosin Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- COVID-19 and healthcare impacts
- Congenital heart defects research
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Acute Ischemic Stroke Management
- Prenatal Screening and Diagnostics
- Colorectal and Anal Carcinomas
- Lymphoma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Diagnosis and treatment of tuberculosis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chemotherapy-induced cardiotoxicity and mitigation
- Phagocytosis and Immune Regulation
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- Neurological Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- NF-κB Signaling Pathways
Jiangsu University
2024-2025
First People's Hospital of Kunshan
2024-2025
Ningxia Medical University
2025
Nanjing Medical University
2015-2024
Wuhan University
2024
Renmin Hospital of Wuhan University
2024
Qingdao Municipal Center for Disease Control and Prevention
2024
Hubei Cancer Hospital
2024
Chinese Center For Disease Control and Prevention
2015-2023
Huazhong University of Science and Technology
2013-2022
Coronavirus disease 2019 (COVID-19) broke out in Wuhan, the People's Republic of China, December and now is a pandemic all around world. Some orthopaedic surgeons Wuhan were infected with COVID-19.We conducted survey to identify who COVID-19 Wuhan. A self-administered questionnaire was distributed collect information such as social demographic variables, clinical manifestations, exposure history, awareness outbreak, infection control training provided by hospitals, individual protection...
Despite extensive studies on post-stroke depression (PSD), the role of total burden cerebral small-vessel disease (cSVD) in its pathogenesis remains unclear.We conducted a magnetic resonance imaging (MRI)-based cohort study to investigate relationship between MRI cSVD and PSD among patients with first-ever lacunar stroke. From June 2013 January 2016, 374 were consecutively recruited. was identified using Chinese version Structured Clinical Interview for DSM-IV. Brain presence silent...
Background: This randomized controlled trial aimed to investigate the potential benefits of local application triamcinolone acetonide combined with topical recombinant bovine basic fibroblast growth factor in promoting wound healing and reducing scar formation after circumcision using a stapler device. Methods: A total 192 patients phimosis or redundant prepuce were randomly assigned either observation group (n = 96) control 96). Both groups underwent Postoperatively, received wet dressings...
Corticosteroids (CSs) are the initial therapy for immune thrombocytopenia (ITP); however, their efficacy is not adequately predicted. As a novel biomarker, composition of gut microbiota non-invasively tested and altered in patients with ITP. This study aims to develop predictive model that leverages microbiome data predict CS response ITP within four weeks treatment. Metagenomic sequencing performed on fecal samples from 212 ITP, 152 whom underwent treatment follow-up. Predictive models...
A nationwide survey of hepatitis B virus (HBV)-associated economic burden has not previously been performed in China. The purpose this study was to examine the direct, indirect, and intangible costs HBV-related diseases within span one year. random sample taken from specialty general hospitals across 12 cities six provinces Intangible were estimated based on willingness pay or open-ended answers provided by patients. results showed that 27 enrolled, with a population 4726 patients (77.7%...
Abstract Background CXCR4 chemokine receptors play an important role in leukemia proliferation, extramedullary migration, infiltration, adhesion, and resistance to chemotherapy drugs. Methods The expression by flow cytometry 122 acute myeloid (AML) patients between 2010 2014 was analyzed. Results of AML‐M4/M5 found be significantly higher than that other subtypes according both FAB subtype WHO classification. FLT3‐ITD mutant high group ( P = .0086). Our data also showed correlated with CD64...
BackgroundAlthough 21 causative mutations have been associated with PRKAG2 syndrome, our understanding of the syndrome remains incomplete. The aim this project is to further investigate its unique genetic background, clinical manifestations, and underlying structural changes.MethodsWe recruited 885 hypertrophic cardiomyopathy (HCM) probands their families internationally. Targeted next-generation sequencing sudden cardiac death (SCD) genes was performed. role identified variants assessed...
To estimate the prevalence, awareness, treatment and control of diabetes in rural areas Shandong Province, China.The Luxemburg-WHO-Shandong Project on Rural Health Personnel Training Chronic Disease Control, a cross-sectional study, examined 16 375 residents aged 25 years over using multistage cluster sampling April 2007. An overnight fasting blood specimen was collected to measure plasma glucose 2-h 75-g oral tolerance test conducted among people with ≥ 6.1 mmol/l. Information history...
Elevated protein expressions of CD markers such as IL2RA/CD25, CXCR4/CD184, CD34 and CD56 are associated with adverse prognosis in acute myeloid leukemia (AML). However, the prognostic value mRNA these AML remains unclear. Through our pilot evaluation, IL2RA expression appeared to be best candidate a biomarker. Therefore, aim this study is characterize evaluate its potential refine prognostification AML.
cCRT is the standard of care in LS-SCLC, but LS-SCLC still represents a significant unmet medical need with median survival 25 to 30 mo. Addition anti-PD-L1 antibody adebrelimab carboplatin and etoposide has demonstrated benefits extensive-stage SCLC phase 3 CAPSTONE-1 trial. This ongoing, 2-stage, study aims evaluate LS-SCLC. In safety run-in stage, patients pathologically confirmed, unresectable were enrolled. Treatment consisted four 3-week cycles (20 mg/kg, iv, d1, Q3W) plus (AUC 5, (100...
Background: Mutations in the TTN gene are most common causes of dilated cardiomyopathy (DCM). The clinical significance variants remains inadequately understood. Methods: Whole-exome sequencing and phenotypic characterisation were performed, patients followed up for a median 44 months. Results: We analyzed association with outcomes prospective study 1,041 sporadic DCM. truncating (tTTN) detected 120 (11.5%) as compared 2.4/10,000 East Asian populations Genome Aggregation Database (GnomAD; p...
OBJECTIVE: We used the Semmes-Weinstein 5.07 monofilament to assess prevalence of foot insensitivity and its relationship potential risk factors. RESEARCH DESIGN AND METHODS: There were 3,638 American Indian participants from Arizona, North South Dakota, Oklahoma who attended a study clinic on two occasions: baseline follow-up, 4 years later. Oral glucose tolerance tests performed at visits for those had not previously been diagnosed as having diabetes. A total 2,051 with diabetes before or...
OBJECTIVE: To describe glycemic control and identify correlates of elevated HbA1c levels in diabetic American Indians participating the Strong Heart Study, which is a longitudinal study cardiovascular disease Arizona, Oklahoma, South Dakota, North Dakota. RESEARCH DESIGN AND METHODS: This analysis based on data from baseline (1989-1992) first follow-up (1994-1995) examinations Study. The 1,581 participants included this were aged 45-74 years at baseline, diagnosed with diabetes before had...
Summary Introduction Detection of leukemogenic fusion transcripts in acute myeloid leukemia ( AML ) is critical for diagnosis. NanoString nC ounter system a novel probe‐based gene expression platform capable measuring up to 800 targets with advantages reproducibility, accuracy, and sample type flexibility. To study the potential application at clinic, we used this technology detect compared performances clinical molecular assays. Methods We developed assay seven transcripts, namely RUNX 1‐...
Coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been associated with cardiovascular features, which may be deteriorated in patients cancer. However, cardiac outcomes of cancer COVID-19 have not closely examined. We retrospectively assessed 1,244 from February 1 August 31, 2020 (140 and 1,104 noncancer patients). Demographic clinical data were obtained compared between groups. Including the biomarkers, we also analyzed laboratory...