A5028810172- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Heart Rate Variability and Autonomic Control
- Ion channel regulation and function
- Atrial Fibrillation Management and Outcomes
- Cardiac Health and Mental Health
- Pharmacological Receptor Mechanisms and Effects
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Cardiovascular Function and Risk Factors
- Neuroscience and Neuropharmacology Research
- COVID-19 Clinical Research Studies
- Food Safety and Hygiene
- Multiple Sclerosis Research Studies
- Vibrio bacteria research studies
- Asthma and respiratory diseases
- Innovations in Medical Education
- Climate Change and Health Impacts
- Fungal Plant Pathogen Control
- Gastric Cancer Management and Outcomes
- Cardiomyopathy and Myosin Studies
- COVID-19 and healthcare impacts
- Protein Kinase Regulation and GTPase Signaling
- Nicotinic Acetylcholine Receptors Study
Hunan Provincial Center for Disease Control and Prevention
2017-2025
Panyu Hospital of Chinese Medicine
2024
Renmin Hospital of Wuhan University
2014-2023
Wuhan University
2014-2023
Guangzhou Medical University
2021
First Affiliated Hospital of Jinan University
2021
Cardiovascular Institute Hospital
2018-2021
Mayo Clinic
2017-2019
Mayo Clinic in Arizona
2017-2019
Guangzhou University of Chinese Medicine
2019
<h3>Importance</h3> Coronavirus disease 2019 (COVID-19) has resulted in considerable morbidity and mortality worldwide since December 2019. However, information on cardiac injury patients affected by COVID-19 is limited. <h3>Objective</h3> To explore the association between with COVID-19. <h3>Design, Setting, Participants</h3> This cohort study was conducted from January 20, 2020, to February 10, a single center at Renmin Hospital of Wuhan University, Wuhan, China; final date follow-up 15,...
It is recognized that monoamine reuptake inhibitors (MARIs) exert beneficial effects in the treatment of major depression and general anxiety disorder. The aim this study was to identify proteins regulated by class antidepressant using a proteome differential profiling approach. Either venlafaxine or fluoxetine administered systemically adult rats for 2 weeks, protein patterns from rat hippocampal cytosolic extracts were compared two-dimensional gel electrophoresis. Silver-stained spots...
<h3>Objective:</h3> To report safety and efficacy outcomes from up to 9 years of treatment with teriflunomide in an extension (NCT00803049) the pivotal phase 3 Teriflunomide Multiple Sclerosis Oral (TEMSO) trial (NCT00134563). <h3>Methods:</h3> A total 742 patients entered extension. Teriflunomide-treated continued original dose; those previously receiving placebo were randomized 1:1 14 mg or 7 mg. <h3>Results:</h3> By June 2013, median (maximum) exposure exceeded 190 (325) weeks per...
All nonmammalian vertebrates studied can regenerate inner ear mechanosensory receptors (i.e., hair cells) (Corwin and Cotanche, 1988; Lombarte et al., 1993; Baird 1996), but mammals possess only a very limited capacity for regeneration after birth (Roberson Rubel, 1994). As result, experience permanent deficiencies in hearing balance once their cells are lost. The mechanisms of cell poorly understood. Because the sensory epithelium is highly conserved all (Fritzsch 2007), we chose to study...
<sec> <b>Introduction</b> : Mushroom poisoning was the leading cause of foodborne disease outbreaks and outbreak-associated deaths in China. outbreak surveillance can provide insight into epidemiological characteristics mushroom poisonings guide policymaking health education to reduce illnesses deaths. </sec><sec> <b>Methods</b> Foodborne Disease Outbreak Surveillance System upgraded 2011 collect during 2010–2020 were selected analyze geographical distribution, seasonal setting food...
Sepsis-induced heart injury is one of the leading causes circulation disorders worldwide. Dapagliflozin, a sodium-glucose cotransporter 2 inhibitor mainly used for controlling blood glucose, has been shown to exert protective effect on cardiomyocytes. However, dapagliflozin against sepsis-induced cardiac and underlying mechanism needs be studied.This study aims investigate cardiomyopathy potential mechanisms involved.The rat model sepsis was constructed by intraperitoneal injection...
Depression is an independent risk factor for cardiovascular events and mortality in patients with myocardial infarction (MI). Excessive sympathetic activation serious remodeling may contribute to this association. The aim of study was discuss the effect depression on activity after MI. Wild-type (WT) rats were divided into a sham group (Sham), (MI), (D), plus (MI+D). Compared controls, MI+D animals displayed depression-like behaviors attenuated body weight gain. evaluation showed increased...
Background: Nontyphoidal Salmonella (NTS) infection is the most commonly reported foodborne gastrointestinal and among top three pathogenic factors of bacterial outbreaks in China.
<title>Abstract</title> Background Nontyphoidal <italic>Salmonella</italic> (NTS) is the most commonly reported foodborne gastrointestinal infection and ranks among top three causes of bacterial outbreaks in China. Methods This study analyzed NTS data from Foodborne Disease Surveillance System China (2013–2022) to summarize epidemiological trends, assess reporting rate changes, examine rural-urban variations. Results During this period, 55,266 cases were reported, with rates increasing...
Coronavirus disease 2019 (COVID-19) has become a global public health crisis. Reduced low-density lipoprotein cholesterol (LDL-C) levels were observed in COVID-19 patients. The present study aimed to explore the relationship between LDL-C and prognosis of severe critical A total 211 patients enrolled divided into four groups according levels, including 53 Group (LDL-C ≥ 2.71 mmol/L), B (2.28 ≤ &lt; C (1.83 2.28 mmol/L) 52 D 1.83 mmol/L). lower critically ill than main symptoms before...
The present study aimed to assess the effect of sigma-1 receptor (S1R) stimulation on autonomic nerve dysfunction and susceptibility atrial fibrillation (AF) in a rat depression model. Male rats were randomly divided into one following four treatment groups: saline [control (CTL)]; + intragastric administration SA4503, an agonist S1R (CTS); chronic unpredictable mild stress (CUMS) produce (MDD); CUMS SA4503 (MDS). Depression-like behaviors, such as reduced sucrose preference, decreased body...
The goal of this study was to assess the effects N-methyl-d-aspartate (NMDA) receptors activation on heart rate variability (HRV) and susceptibility atrial fibrillation (AF).Rats were randomized for treatment with saline, NMDA (agonist receptors), or plus MK-801 (antagonist receptors) 2 weeks. Heart evaluated by using implantable electrocardiogram telemeters. Atrial assessed programmed stimulation in isolated hearts. Compared controls, NMDA-treated rats displayed a decrease standard...
Foodborne diseases have become a serious public health problem worldwide, and foodborne disease outbreaks placed heavy burden on China. occur most frequently among families in The objectives of this study were to analyze the cause household China from 2010 2020 identify where preventive measures could be targeted. All data obtained Disease Surveillance System Report. A total 17,985 outbreaks, which resulted 73,252 illnesses, 38,829 hospitalizations, 1269 deaths, reported period. Most...
Background N‐Methyl‐ d ‐aspartate receptors, also known as NMDA Receptors or NMDAR, are glutamate receptors that control calcium ion channels and regulate synaptic plasticity. Acute NMDAR activation can induce ventricular arrhythmias (VAs). However, the influence of chronic on cardiac electrophysiology remains unknown. Methods Results Wistar rats were randomly administered 0.9% saline (CTL group), (N plus MK801 (N+M group) for 14 days. Compared with CTL group, N group displayed elevated...
Ventricular arrhythmias (VAs) are a common complication of chronic ischaemic heart failure (CIHF). The purpose this study is to investigate the efficacy pinocembrin in rat model VAs induced by CIHF and further examine possible mechanism.Rats were subjected ligation left anterior descending coronary artery mimic then received treatment daily for 2 months. vivo electrophysiology performed determine effect on ventricular electrical activity. expression Cav1.2, Kv4.2, NGF was determined Western...
Wuhan was the first large city where initial breakout of COVID-19 took numerous lives. A group social workers and mental health specialists coordinated "Be Together Program" (BTP), a psychosocial grief intervention program to help bereaved people. Under Dual-process model framework, BTP used internet media as main tools, combined with individual intervention. Additionally, it employed "Supermarket Mode" abundant themes approaches for participants choose according their special needs. Chinese...
Intervertebral disc degeneration (IDD) is one of the major leading causes back pain affecting patient's quality life. However, roles circular RNA (circRNA) in IDD remains unclear. This study aimed to explore function and underlying mechanism circ_0036763 IDD. In this study, expressions circ_0036763, U2 small nuclear auxiliary factor 2 (U2AF2), miR-583 aggrecan (ACAN) primary human nucleus pulposus cells (HNPCs) derived from patients healthy controls were detected by quantitative real-time...
Abstract: The regional distributions of the G protein β subunits (Gβ1–β5) and Gγ3 subunit were examined by immunohistochemical methods in adult rat brain. In general, Gβ widely distributed throughout brain, with most regions containing several within their neuronal networks. olfactory bulb, neocortex, hippocampus, striatum, thalamus, cerebellum, brainstem exhibited light to intense immunostaining. Negative immunostaining was observed cortical layer I for Gβ1 IV Gβ4. hippocampal dentate...
Bacillary dysentery remains a public health concern in the world. Hunan Province is one of provinces having highest risk bacillary China, however, spatial-temporal distribution, variation and sensitivity to meteorological factors there are unclear. In this paper, Bayesian space-time hierarchical model (BSTHM) was used detect variation, effects between 2010 2015. The showed apparent heterogeneity. occurred summer season. Economically undeveloped mountainous areas west south province had...
Background: Depression is associated with the increased risk of mortality and morbidity an independent factor for many cardiovascular diseases. may promote cardiac arrhythmias, but little known about mechanisms. Pinocembrin mitigated depressive-like behaviors exhibited cardioprotective effects in several models; however, whether pinocembrin benefits ventricular arrhythmias depression models has not been elucidated. Thus, this study was to evaluate on fibrillation susceptibility rat...