A5100650787- Obstructive Sleep Apnea Research
- Acute Myocardial Infarction Research
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular and Diving-Related Complications
- Cardiovascular Disease and Adiposity
- Coronary Interventions and Diagnostics
- COVID-19 Clinical Research Studies
- Cardiac Fibrosis and Remodeling
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrest and Resuscitation
- Heart Failure Treatment and Management
- Tracheal and airway disorders
- Cardiac Valve Diseases and Treatments
- Acute Ischemic Stroke Management
- Neuroscience of respiration and sleep
- Heart Rate Variability and Autonomic Control
- Cardiac Ischemia and Reperfusion
- Cardiovascular Syncope and Autonomic Disorders
- Signaling Pathways in Disease
- COVID-19 diagnosis using AI
- MicroRNA in disease regulation
Beijing Anzhen Hospital
2017-2025
Capital Medical University
2009-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Beijing Institute of Water
2018-2024
National Clinical Research Center for Digestive Diseases
2022-2024
Wuhan University
2019-2024
Renmin Hospital of Wuhan University
2019-2024
First Hospital of Jilin University
2024
Jilin University
2024
Fudan University
2010-2023
<h3>Importance</h3> Coronavirus disease 2019 (COVID-19) has resulted in considerable morbidity and mortality worldwide since December 2019. However, information on cardiac injury patients affected by COVID-19 is limited. <h3>Objective</h3> To explore the association between with COVID-19. <h3>Design, Setting, Participants</h3> This cohort study was conducted from January 20, 2020, to February 10, a single center at Renmin Hospital of Wuhan University, Wuhan, China; final date follow-up 15,...
Coronavirus disease 2019 (COVID-19) has spread globally, and medical resources become insufficient in many regions. Fast diagnosis of COVID-19 finding high-risk patients with worse prognosis for early prevention resource optimisation is important. Here, we proposed a fully automatic deep learning system diagnostic prognostic analysis by routinely used computed tomography. We retrospectively collected 5372 tomography images from seven cities or provinces. Firstly, 4106 were to pre-train the...
This retrospective study was designed to explore whether neutrophil lymphocyte ratio (NLR) is a prognostic factor in patients with coronavirus disease 2019 (COVID-19). A cohort of COVID-19 admitted the Tongren Hospital Wuhan University from 11 January 2020 3 March retrospectively analyzed. Patients hematologic malignancy were excluded. The NLR calculated by dividing count count. values measured at time admission. primary outcome all-cause in-hospital mortality. multivariate logistic analysis...
Circulating miRNAs have been shown as promising biomarkers for various pathologic conditions.The aim of this study was to clarify that circulating miR-1 and miR-126 in human plasma might be useful acute myocardial infarction (AMI).In our study, after pre-test, two candidate were detected by using real-time RT-PCR.Cardiac troponin I (cTnI) concentrations measured ELISA assay from patients with AMI (n=17) healthy subjects (n=25), simultaneously.Increased decreased the onset symptoms compared...
Background MicroRNAs (miRNAs) play key roles in diverse biological and pathological processes, including the regulation of proliferation, apoptosis, angiogenesis cellular differentiation. Recently, circulating miRNAs have been reported as potential biomarkers for various pathologic conditions. This study investigated miR-30a, miR-195 let-7b biomarker acute myocardial infarction (AMI). Methods Results Plasma samples from 18 patients with AMI 30 healthy adults were collected. Total RNA was...
The impact of sex on the association obstructive sleep apnoea (OSA) with recurrent cardiovascular events following acute coronary syndrome (ACS) remains uncertain. This study sought to examine between OSA and long-term outcomes in women men ACS.In this prospective cohort study, we recruited 2160 ACS patients undergoing portable monitoring June 2015 January 2020. primary end-point was major adverse cerebrovascular event (MACCE), including death, myocardial infarction, stroke, ischaemia-driven...
Serum lipids and the ratios are known to be associated with cardiovascular diseases (CVD). However, associations of serum related arterial stiffness unclear. We sought compare strength these assessing by brachial-ankle pulse wave velocity (baPWV) in middle-aged elderly Chinese subjects. A total number 1133 aged from 50 90 years old were recruited Shanghai downtown district. The lipids, baPWV major risk factors participants measured. Participants high exhibited higher levels non-HDL-c,...
BACKGROUND: Postprocedural anticoagulation (PPA) is frequently administered after primary percutaneous coronary intervention in ST-segment–elevation myocardial infarction, although no conclusive data support this practice. METHODS: The RIGHT trial (Comparison of Anticoagulation Prolongation vs STEMI Patients After Primary PCI) was an investigator-initiated, multicenter, randomized, double-blind, placebo-controlled, superiority conducted at 53 centers China. with infarction undergoing were...
Aortic valve (AV) calcification occurs via a pathophysiological process that includes lipoprotein deposition, inflammation, and osteoblastic differentiation of valvular interstitial cells. Here, we investigated the association between endoplasmic reticulum (ER) stress AV calcification.We identified ER activation in patients with calcified stenosis. We generated an model hypercholesterolemic rabbits mice, respectively, found marked induction. Classical inhibitor, tauroursodeoxycholic acid,...
Multiple factors have been shown to promote the progression of diabetic cardiomyopathy. A link has previously found between Mir30 and autophagy in cancer cells heart, but role heart not studied. Using vitro vivo approaches, we that depletion Mir30c induction BECN1 enhanced (db/db) hearts cardiomyocytes treated with fatty acid palmitate. We verified repressed expression by direct binding 3' UTRs. overexpression inhibited subsequent improved cardiac function structure mice. However, these...
Abstract Aims This study sought to evaluate the association of coronary angiography-derived index microcirculatory resistance (angio-IMR) measured after primary percutaneous intervention (PPCI) with evolution infarct pathology during 3-month follow-up ST-segment-elevation myocardial infarction (STEMI). Methods and Results Patients STEMI undergoing PPCI were prospectively enrolled between October 2019 August 2021. Angio-IMR was calculated using computational flow pressure simulation...
Background The circadian rhythm of myocardial infarction (MI) in patients with obstructive sleep apnea (OSA) remains disputable and no studies have directly evaluated the relationship between nocturnal hypoxemia MI. aim current study was to evaluate association OSA MI onset during night. Methods Patients OSA‐acute coronary syndrome (ACS) project (NCT03362385) were recruited. time identified by patient's report chest pain that prompted hospital admission. All underwent an overnight using a...
Spironolactone (SPR) has been shown to protect diabetic cardiomyopathy (DCM), but the specific mechanisms are not fully understood. Here, we determined cardioprotective role of SPR in mice and further explored potential both vivo vitro models. Streptozotocin- (STZ-) induced rats were used as model. After onset diabetes, treated with either (STZ + SPR) or saline NS) for 12 weeks; nondiabetic controls (NDCs). In vitro, H9C2 cells exposed aldosterone, without SPR. Cardiac structure was...
// Yanru Zhao 1, * , Mengwen Yan 2, Chen Wei Gong 3 Zhongwei Yin 1 Huaping Li Jiahui Fan Xin A. Zhang 4 Dao Wen Wang and Houjuan Zuo Division of Cardiology Hubei Key Laboratory Genetics Molecular Mechanisms Cardiological Disorders, Tongji Hospital, Medical College, Huazhong University Science Technology, Wuhan, People's Republic China 2 Department Cardiology, China-Japan Friendship Beijing, Emergency Critical Care Center, Beijing Anzhen Capital University, Stephenson Cancer Center...
Objective: To investigate the predictive value of prognosis primary GBM patients using TMT on three-dimensional (3D) MR images brain. Methods: Data 130 with from TCGA-GBM database were analyzed retrospectively. was measured axial plane by multi-planar reformation (MPR) T1WI perpendicular to long axis temporal muscle at level orbital roof. The oriented parallel anterior commissure-posterior commissure line. Student᾽s t-test or Mann-Whitney U test utilized determine whether there significant...
Lymphatic malformation (LM) in the abdomen is uncommon children, and standard treatment surgical excision. The present study aimed to evaluate safety efficacy of laparoscopic surgery intra‑abdominal LM a pediatric population. medical records 10 children with treated by resection from March 2017 June 2021 Second Affiliated Hospital Xi'an Jiaotong University (Xi'an, China) were retrospectively reviewed. Equal numbers female male patients included underwent at median age 55 months (range, 40...
Summary Background/Aims Cardiac rupture ( CR ) is a catastrophic complication of acute myocardial infarction MI ). At present, there are no effective pharmacological strategies for preventing post‐ rupture. Here we investigated the effect trimetazidine TMZ on . Methods models were induced by left coronary artery ligation in male C57 BL /6 mice. Animals allocated to incidence closely monitored 7 days; autopsy was performed once animals found dead determine reason death. Heart function...