A5062629713- Cardiac Ischemia and Reperfusion
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- Cardiovascular Disease and Adiposity
- Atrial Fibrillation Management and Outcomes
- Sepsis Diagnosis and Treatment
- Genomics, phytochemicals, and oxidative stress
- Angiogenesis and VEGF in Cancer
- Tryptophan and brain disorders
- Cardiac Fibrosis and Remodeling
- GDF15 and Related Biomarkers
- Coronary Interventions and Diagnostics
- Pharmacological Receptor Mechanisms and Effects
- Renin-Angiotensin System Studies
- Cardiac Health and Mental Health
- Sirtuins and Resveratrol in Medicine
- Gout, Hyperuricemia, Uric Acid
- Metabolism, Diabetes, and Cancer
- Anesthesia and Neurotoxicity Research
- Medicinal Plants and Bioactive Compounds
- Cardiac Imaging and Diagnostics
- FOXO transcription factor regulation
Wuhan University
2012-2022
Renmin Hospital of Wuhan University
2012-2022
Northeast Ohio Medical University
2017-2019
University of Pennsylvania
2016
Virginia Commonwealth University Medical Center
2014
Previous studies indicate resveratrol pretreatment can protect cardiomyocytes. However, it is largely unknown whether protects cardiomyocytes when applied at reperfusion. The purpose of this study was to investigate given reoxygenation could under the anoxia/reoxygenation (A/R) condition and examine underlying mechanism. In study, primary cultures neonatal rat were randomly distributed into three groups: control group, A/R group (cultured subjected 3 h anoxia followed by 2 reoxygenation),...
Oxidative stress is an important factor involved in the progress of heart failure. The current study was performed to investigate whether pinocembrin able ameliorate post-infarct failure (PIHF) and underlying mechanisms.Rats were carried out left anterior descending artery ligation induce myocardial infarction subsequently raised for 6 weeks produce chronic Then administrated every other day 2 weeks. effects evaluated by echocardiography, western blot, Masson's staining, biochemical...
Cardiac fibroblast (CF) proliferation and transformation into myofibroblasts play important roles in cardiac fibrosis during pathological myocardial remodeling. In this study, we demonstrate that hepatocyte growth factor (HGF), an antifibrotic the process of pulmonary, renal liver fibrosis, is a negative regulator response to transforming factor‑β1 (TGF‑β1). HGF expression levels were significantly reduced CFs following treatment with 5 ng/ml TGF‑β1 for 48 h. The overexpression suppressed...
Abstract Control of the malaria vector An. gambiae is still largely obtained through chemical intervention using pyrethroids, such as permethrin. However, strains that are resistant to toxic effects pyrethroids have become widespread in several endemic areas over last decade. The objective this study was assess differences five life-history traits (larval developmental time and body weight, fecundity, hatch rate, longevity adult females) energy metabolism between a strain permethrin (RSP),...
Oxidative stress and cardiomyocytes apoptosis were closely involved in the pathological process of doxorubicin- (Dox-) induced cardiac injury. MicroRNA-451 (miR-451) was mainly expressed cardiomyocytes. However, role miR-451 Dox-induced injury remained unclear. Our study aimed to investigate effect on cardiotoxicity mice. We established a model mice manipulated expression heart using inhibitor, which injected every other day beginning at one before Dox injection. hearts evaluated. levels...
Basic fibroblast growth factor (bFGF), a known angiogenic factor, may provide potential strategy for the treatment of myocardial infarction (MI), but it is limited by relatively short half-life. Dex-PCL-HEMA/PNIPAAm hydrogel provides reservoir controlled release factors. The aim current study was to evaluate effects bFGF incorporated into on angiogenesis and cardiac health in rat model acute MI, induced coronary artery ligation. Phosphate-buffered solution (PBS group), (Gel...
Background: Depression is associated with the increased risk of mortality and morbidity an independent factor for many cardiovascular diseases. may promote cardiac arrhythmias, but little known about mechanisms. Pinocembrin mitigated depressive-like behaviors exhibited cardioprotective effects in several models; however, whether pinocembrin benefits ventricular arrhythmias depression models has not been elucidated. Thus, this study was to evaluate on fibrillation susceptibility rat...
The expression of foreign gene was enhanced and prolonged by sustained releasing a target to cells from biodegradable dextran-poly(e-caprolactone)-2-hydroxylethylmethacrylate-poly(N-isopropylacrylamide) (Dex-PCL-HEMA/PNIPAAm) hydrogel in vitro. Moreover, we have demonstrated that injection the same improved post-infarct ventricular remodeling. Therefore, hypothesized intramyocardial plasmid containing short-hairpin RNA (shRNA) angiotensin converting enzyme (ACE) with enhances...
Objective: To evaluate the quality of life (QoL), health‐care resource utilization, and cost for patients with premature ventricular contractions (PVCs) by radiofrequency catheter ablation (RFCA). Methods: RFCA was performed in 58 symptomatic PVCs that were refractory/easy to medication. A 24‐hour ambulatory electrocardiographic monitoring, QoL, resources assessed at a screening visit 3 12 months after RFCA. Results: successfully 56 (96.6%). This resulted significant improvement QoL...
Although ginkgo biloba extract (GBE) was shown to have antioxidant effects, little has been reported on the ability GBE help endothelial progenitor cells (EPCs) resist oxidative stress. The present study evaluated influence of different concentrations superoxide dismutase (SOD) and apoptosis diabetic peripheral blood EPCs. Twenty-five patients without any vascular complications were included in experimental group, while 15 healthy adults made up control group. Peripheral mononuclear isolated...
Sigma 1 receptor (S1R) has shown a preferable protective effect on left ventricular function, but whether it protects right (RV) function is still elusive.This study aimed to determine the effects of S1R RV dysfunction secondary pulmonary arterial hypertension.Sixty wild-type male Sprague-Dawley rats were randomly divided into control group, fluvoxamine hypertension group and combined with group. Monocrotaline (60 mg/kg) was administered induce hypertension, given for 21 consecutive days...
Inhibition of the angiotensin‑converting enzyme (ACE) attenuated apoptotic cardiomyocytes induced by ischemic reperfusion (I/R). However, it is difficult to evaluate effects inhibition intracellular ACE in vivo. The objective this study was determine whether apoptosis H9c2 following anoxia/reoxygenation (A/R) would be improved silencing RNA interference (RNAi). were subjected A/R 48 h transfection with ACE-shRNA plasmid. results showed that gene significantly inhibited decrease cell...
Background Depression is often comorbid with cardiovascular diseases and contributes to the development maintenance of atrial fibrillation (AF). Ample research demonstrated that pinocembrin had protective effects on neuropsychiatric systems via its pharmacological properties. However, whether protects from AF in depression models not known. The present investigated antiarrhythmic underlying mechanisms depressed rats. Methods One hundred ten male Sprague Dawley rats were randomly divided into...
What is the central question of this study? The enzyme system that responsible for extracellular matrix (ECM) turnover metalloproteinases (MMPs), which can be blocked by tissue inhibitors MMPs (TIMPs). Whether renal sympathetic denervation (RSD) able to ameliorate post-myocardial infarction left ventricular remodelling through attenuation ECM via regulation MMP activity and/or MMP-TIMP complex remains unknown. main finding and its importance? Renal has therapeutic effects on remodelling,...
BACKGROUND:The role of renal sympathetic denervation (RSD) in ameliorating post-myocardial infarction (MI) left ventricular (LV) fibrosis via microRNA-dependent regulation connective tissue growth factor (CTGF) remains unknown. MATERIAL AND METHODS:MI and RSD were induced Sprague–Dawley rats by ligating the coronary artery denervating bilateral nerves, respectively. Norepinephrine, renin, angiotensin II aldosterone plasma, collagen, microRNA21, microRNA 101a, 133a CTGF heart tissue, as well...
Background: Anxiety disorder (AD) is the most common mental disorder, which closely related to atrial fibrillation (AF) and considered be a trigger of AF. Pinocembrin has been demonstrated perform variety neurological cardiac protective effects through its anti-inflammatory antioxidant activities. The current research aims explore antiarrhythmic effect pinocembrin in anxiety rats underlying mechanisms. Methods: 60 male Sprague-Dawley were distributed into four groups: CTL group: control +...