A5036296381- Multiple Sclerosis Research Studies
- Migraine and Headache Studies
- Pain Mechanisms and Treatments
- Peripheral Neuropathies and Disorders
- Trigeminal Neuralgia and Treatments
- Musculoskeletal pain and rehabilitation
- Dermatology and Skin Diseases
- Ophthalmology and Eye Disorders
- Polyomavirus and related diseases
- Systemic Lupus Erythematosus Research
- Pain Management and Placebo Effect
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience of respiration and sleep
- Allergic Rhinitis and Sensitization
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Urticaria and Related Conditions
- Genetic Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- Pharmacological Effects of Natural Compounds
- Long-Term Effects of COVID-19
- Systemic Sclerosis and Related Diseases
- Neurological disorders and treatments
- Olfactory and Sensory Function Studies
- Cell Adhesion Molecules Research
- Reproductive System and Pregnancy
Isar-Amper-Klinikum München-Ost
2014-2024
Medizinische Hochschule Hannover
2009-2024
Ludwig-Maximilians-Universität München
2024
Jena University Hospital
2022
Centre Hospitalier Universitaire de Lille
2022
Hospital Arnau de Vilanova
2022
AB Science (France)
2022
Hospital Universitari de Girona Doctor Josep Trueta
2022
University of Girona
2022
Inserm
2022
Abstract Background The diagnostic and pathophysiological relevance of antibodies to aquaporin-4 (AQP4-Ab) in patients with neuromyelitis optica spectrum disorders (NMOSD) has been intensively studied. However, little is known so far about the clinical impact AQP4-Ab seropositivity. Objective To analyse systematically paraclinical features associated NMO Caucasians a stratified fashion according patients' serostatus. Methods Retrospective study 175 Caucasian (AQP4-Ab positive 78.3%). Results...
Experimental determination of pain sensitivity has received increasing attention because emerging clinical applications (including prediction postoperative and treatment response) scientific implications (e.g. it been proposed that above-average is a risk factor for the development chronic disorders). However, use experimental assessment on broad scale hampered by its requirements time, equipment human resources fact painful tested subject. Alternatives to testing are currently lacking. Here...
To analyze whether 1 of the 2 apheresis techniques, therapeutic plasma exchange (PE) or immunoadsorption (IA), is superior in treating neuromyelitis optica spectrum disorder (NMOSD) attacks and to identify predictive factors for complete remission (CR).This retrospective cohort study was based on registry German Neuromyelitis Optica Study Group, a nationwide network established 2008. It recruited patients with diagnosed according 2006 Wingerchuk criteria aquaporin-4...
Recently, a self-rating measure for pain perception based on imagined painful daily life situations, the Pain Sensitivity Questionnaire (PSQ), has been developed and shown to correlate with experimentally obtained intensity ratings in healthy subjects. Here, we assessed validity of PSQ investigation general (ie, outside site clinical pain) chronic patients. scores were 134 patients compared those 185 control In subgroup 46 patients, performed experimental testing site, including different...
Background Experimental stress has been shown to have analgesic as well allodynic effect in animals. Despite the obvious negative influence of clinical pain conditions, stress-induced alteration sensitivity not tested humans so far. Therefore, we changes using an experimental stressor ten female healthy subjects and 13 patients with fibromyalgia. Methods Multiple sensory aspects were evaluated all participants help quantitative testing protocol before (60 min) after (10 90 inducing...
To analyse predictors for relapses and number of attacks under different immunotherapies in patients with neuromyelitis optica spectrum disorder (NMOSD).This is a retrospective cohort study conducted neurology departments at 21 regional university hospitals Germany. Eligible participants were aquaporin-4-antibody-positive or aquaporin-4-antibody-negative NMOSD. Main outcome measures HRs from Cox proportional hazard regression models adjusted centre effects, important prognostic factors...
Journal Article Reduced intraepidermal nerve fibre density in lesional and nonlesional prurigo nodularis skin as a potential sign of subclinical cutaneous neuropathy Get access B. Schuhknecht, Schuhknecht Departments Dermatology Search for other works by this author on: Oxford Academic Google Scholar M. Marziniak, Marziniak Neurology, Competence Center Chronic Pruritus, University Hospital Münster, Von‐Esmarch‐Str. 58, D‐48149 Germany A. Wissel, Wissel N.Q. Phan, Phan D. Pappai, Pappai J....
<h3>Objective:</h3> To report safety and efficacy outcomes from up to 9 years of treatment with teriflunomide in an extension (NCT00803049) the pivotal phase 3 Teriflunomide Multiple Sclerosis Oral (TEMSO) trial (NCT00134563). <h3>Methods:</h3> A total 742 patients entered extension. Teriflunomide-treated continued original dose; those previously receiving placebo were randomized 1:1 14 mg or 7 mg. <h3>Results:</h3> By June 2013, median (maximum) exposure exceeded 190 (325) weeks per...
Despite recent advances in multiple sclerosis (MS) care, many patients only infrequently access health care services, or are unable to them easily, for reasons such as mobility restrictions, travel costs, consultation and treatment time constraints, a lack of locally available MS expert services. Advances mobile communications have led the introduction electronic (eHealth) technologies, which helping improve both quality As Internet is now readily accessible through smart devices, most...
Environmental conditions (eg, latitude) play a critical role in the susceptibility and severity of many autoimmune disorders, including multiple sclerosis (MS). Here, we investigated mechanisms underlying beneficial effects immune regulatory processes induced skin by moderate ultraviolet B (UVB) radiation on central nervous system (CNS) autoimmunity.Effects UVB light were analyzed murine model CNS autoimmunity (experimental encephalomyelitis). Additionally, patients with relapsing-remitting...
Treatment of neuropathic pain (NP) symptoms associated with multiple sclerosis (MS) is frequently insufficient. Yet, cannabis still rarely offered for treatment pain. This clinical trial aimed at showing the positive benefit-risk ratio dronabinol. Two hundred forty MS patients central NP entered a 16-weeks placebo-controlled phase-III study followed by 32-weeks open-label period. One continued therapy overall up to 119 weeks. Primary endpoint was change intensity on 11-point Numerical Rating...
Masitinib is a selective tyrosine kinase inhibitor, targeting innate immune cells (mast and microglia) that are involved in the pathophysiology of progressive multiple sclerosis (MS). Study AB07002 assessed oral masitinib patients with MS who were progressing but not clinically active.
Tumor necrosis factor alpha (TNF) may be involved in the pathogenic mechanisms of neuropathic pain by affecting endothelial cells and upregulation receptor sensitivity afferent nerve fibers. To test hypothesis that TNF plays a role vascular changes pain-related behavior an experimental painful neuropathy rats produced tying loosely constrictive ligatures around one sciatic nerve, we investigated effect thalidomide, selective blocker TNF-production activated macrophages. In which treatment...
Etanercept, a recombinant tumor necrosis factor receptor (p75)-Fc fusion protein competitively inhibits factor-alpha (TNF). Etanercept has been successfully used in patients with rheumatoid arthritis, where it reduces pain and inflammation. Because locally produced proinflammatory cytokines play role after nerve injury, we investigated whether etanercept can reduce hyperalgesia an animal model of painful neuropathy, the chronic constriction injury sciatic nerve. C57BL/6 mice received or sham...
Thalidomide reduces thermal hyperalgesia and mechanical allodynia in chronic constrictive sciatic nerve injury (CCI). Since thalidomide mainly inhibits tumor necrosis factor alpha (TNF-α) synthesis with less well defined effects on other cytokines, we investigated the effect of drug expression proinflammatory cytokines TNF-α, interleukin-1β (IL-1β) interleukin 6 (IL-6), anti-inflammatory cytokine interleukin-10 (IL-10) lesioned rat nerve. The increase endoneurial TNF-α during first week...
Background In neurological diseases presenting with a plethora of symptoms, the value bodily functions for given patient might be guide clinical management. Multiple sclerosis (MS) is paradigmatic in this respect, and little known about different patients their physicians' perceptions. Methods multicenter study, 171 relapsing-remitting multiple (RRMS), 61% clinically active disease within last 2 years were followed over up to 3 yearly study physician rated on perceived 13 via priority list....
<h3>Objective</h3> To evaluate the efficacy of an evidence-based patient information programme aiming to increase informed choice in patients with early multiple sclerosis (MS). <h3>Background</h3> Patients MS face a number uncertainties concerning diagnosis, prognosis and effectiveness immunotherapy. Prior studies suggest that combined group education can promote patients. <h3>Methods</h3> A 12-month, six-centre, double-blind randomised controlled clinical trial 192 diagnosis confirmed...