A5011832110- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Sympathectomy and Hyperhidrosis Treatments
- Genetic Neurodegenerative Diseases
- Acute Ischemic Stroke Management
- Neurological Disorders and Treatments
- Alzheimer's disease research and treatments
- Pain Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Ophthalmology and Eye Disorders
- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- Sleep and Wakefulness Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Neurological diseases and metabolism
- Advanced Neuroimaging Techniques and Applications
- Restless Legs Syndrome Research
- Cerebrovascular and Carotid Artery Diseases
- Multiple Sclerosis Research Studies
- Functional Brain Connectivity Studies
- Amyotrophic Lateral Sclerosis Research
- Prion Diseases and Protein Misfolding
Medical University of Vienna
2011-2021
University of Vienna
1994-2014
International Neuromodulation Society
2013
Vienna General Hospital
2004-2009
Ludwig Boltzmann Institute for Digital Health and Prevention
2005
Statistics Austria
2003
University Clinic of Traumatology
1993-2001
Klinik und Poliklinik für Psychiatrie und Psychotherapie
1999
Sigmund Freud University Vienna
1991
In multiple sclerosis (MS), iron accumulates inside activated microglia/macrophages at edges of some chronic demyelinated lesions, forming rims. susceptibility-based magnetic resonance imaging 7 T, iron-laden induce a rim decreased signal lesion and have been associated with slowly expanding lesions. We aimed to determine (1) what types stages are accumulation their edges, (2) cells the accumulate is activation status, (3) how reliably can edge be detected by T (MRI), (4) if lesions rims...
Abstract Several randomized placebo‐controlled trials have consistently shown antidyskinetic effects of amantadine in levodopa treated patients with advanced Parkinson's disease (PD). However, all these were short duration and there been claims that the effect on induced dyskinesias (LID's) wear off after about 9 months treatment. This parallel‐group study was performed to assess long‐term 32 PD patients, who having stable therapy for LID over at least one year‐ switched a double blind...
<h3>Objective:</h3> To report safety and efficacy outcomes from up to 9 years of treatment with teriflunomide in an extension (NCT00803049) the pivotal phase 3 Teriflunomide Multiple Sclerosis Oral (TEMSO) trial (NCT00134563). <h3>Methods:</h3> A total 742 patients entered extension. Teriflunomide-treated continued original dose; those previously receiving placebo were randomized 1:1 14 mg or 7 mg. <h3>Results:</h3> By June 2013, median (maximum) exposure exceeded 190 (325) weeks per...
Background: Health related quality of life (HRQOL) is an important issue in the context dementia care. Objectives: The purpose this study was to investigate HRQOL patients with subjective cognitive decline (SCD) and mild impairment (MCI) its relation Activity Daily Li ving (ADL). Methods: In cross sectional study, four experimental groups (each n = 98), controls, SCD, naMCI aMCI, were compared. For data collection, neuropsychological methods (NTBV) psychological questionnaires (SF-36 B-ADL)...
Background: Subjective cognitive decline (SCD) may be an early indicator for increased risk of dementia. The exact definition SCD remains unclear and has recently become a major research interest. Objectives: To determine impairments in activities daily living (ADL) depressive symptoms elderly individuals with SCD, mild impairment (MCI), Alzheimer’s disease (AD). Methods: We included 752 consecutive patients suffering from non-amnestic (naMCI) or amnestic MCI (aMCI), AD, 343 healthy controls...
Background and purpose Impaired dexterity (fine hand movements) is often present in Parkinson's disease ( PD ), even at early to moderate stages. It has a detrimental impact on activities of daily living ADL ) such as buttoning, contributing reduced quality life. Limb‐kinetic apraxia, loss the ability make precise, independent but coordinated finger movements, may contribute impaired more than bradykinesia per se . However, limb‐kinetic apraxia remains controversial. Our aim was identify...
The blocking action of botulinum toxin type A (BTX-A) on cholinergically innervated sweat glands has been used successfully to treat patients with focal hyperhidrosis.To investigate the long-term efficacy and safety intradermal injections BTX-A.We performed an open-label study in 61 treated over a period 3 years for axillary or palmar hyperhidrosis. total dose 400 mU BTX-A (Dysport) was injected into both axillae 460 palms. were repeated after relapse. Objective quantification production...
Mutations in the valosin-containing protein (VCP) on chromosome 9p13-p12 were recently found to be associated with hereditary inclusion body myopathy, Paget disease of bone, and frontotemporal dementia (IBMPFD). We identified a novel missense mutation VCP gene (R159H; 688G>A) segregating this an Austrian family four affected siblings, who exhibited progressive proximal myopathy bone but without clinical signs dementia.
<b><i>Objective:</i></b> Botulinum toxin type A (BTXA) is used to treat neurologic disorders associated with increased muscle tone. Its use often pain relief. <b><i>Methods:</i></b> possible direct analgesic effect of BTXA on C and Aδ fibers was studied 16 healthy volunteers receiving 30 U into one forearm pure saline the other. To exclude secondary due muscular tone reduction, injected intradermally. Thermal sensory testing heat (threshold tolerance) neuroselective current...
Compared with a group of age matched controls, patients Parkinson9s disease scored significantly lower in testing for ideomotor apraxia. Imitation movement sequences was affected more severely than performance single movements. The degree impairment not related to severity motor disability, but correlated strongly the results tests that measured visuospatial and visuoperceptive abilities. It is suggested defective encoding central processing information impairs memory which necessary correct...
The goals of this study were to establish prevalence subjective memory complaints (SMC) and depressive symptoms (DS) their relation cognitive functioning status in an outpatient clinic cohort.Two hundred forty-eight cognitively healthy controls 581 consecutive patients with who fulfilled the inclusion criteria included study.A statistically significant difference (p < 0.001) between control group patient regarding mean SMC was detected. 7.7% reported a considerable degree SMC, whereas 35.8%...
Antonovsky's salutogenic model of the "Sense Coherence" (SOC) is an important resource in dealing with chronic diseases. The aim this study was to investigate SOC as a psychological factor and its correlation illness, subjective well-being, health-related quality life (QoL) patients Parkinson disease (PD) compared other diseases.Fifty-one suffering from PD 59 participants non-neurological diseases took part study. were assessed through medical routine examinations all asked complete several...
The goal of this study was to establish the prevalence subjective memory complaints (SMCs) and depressive symptoms (DS)s their relation cognitive functioning in patients with Parkinson's disease (PD).In all, 248 controls 104 PD were included study. group subdivided into three subtypes mild impairment (MCI) according Petersen criteria MCI Litvan criteria.Substantial SMCs reported by 7.7% 16.3% (P < 0.001). A clinically relevant degree DSs evident 16.6% compared 40.4% An analysis variance...
Abstract Theory of Mind (ToM) is the ability to represent and attribute mental states oneself others. So far, research regarding ToM processing across adolescence scarce. Existing studies either yield inconsistent results or did not thoroughly investigate aspects like higher order associated neuropsychological variables which current study tried address. 643 typically developing early, middle, late adolescents (age groups 13–14; 15–16; 17–18) performed cognitive affective tasks as well...
Abstract Subjective emotional arousal in typically developing adults was investigated an explorative study. 177 participants (20–70 years) rated facial expressions and words for self-experienced perceived intensity, completed the Difficulties Emotion Regulation scale Hospital Anxiety Depression (HADS-D). Exclusion criteria were psychiatric or neurological diseases, clinically relevant scores HADS-D. Arousal regarding faces significantly predicted by clarity. Separate analyses showed...