A5062370645- Child and Adolescent Psychosocial and Emotional Development
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child Abuse and Trauma
- Mental Health Research Topics
- Thyroid Disorders and Treatments
- Mental Health Treatment and Access
- Aging, Health, and Disability
- Maternal Mental Health During Pregnancy and Postpartum
- Psychological Treatments and Disorders
- Psychosomatic Disorders and Their Treatments
- Dementia and Cognitive Impairment Research
- Attachment and Relationship Dynamics
- Cardiac Health and Mental Health
- Intergenerational Family Dynamics and Caregiving
- Stress Responses and Cortisol
- Genetic Associations and Epidemiology
- Personality Disorders and Psychopathology
- Thyroid Cancer Diagnosis and Treatment
- Mind wandering and attention
- Digital Mental Health Interventions
- Family Caregiving in Mental Illness
- Stress and Burnout Research
- Prenatal Substance Exposure Effects
- Fungal Plant Pathogen Control
- Elder Abuse and Neglect
University of Chile
1983-2025
Centro de Estudios Científicos
2023
OncoMed (United States)
2007-2021
Millennium Institute for Research in Depression and Personality
2017-2021
Millennium Science Initiative
2021
Pontificia Universidad Católica de Chile
1997-2002
Instituto Nacional del Tórax
2000-2001
Endocrinology Research Center
1999
Stanford University
1981
Hadassah Medical Center
1981
Immediate-release memantine (10 mg, twice daily) is approved in the USA for moderate-to-severe Alzheimer's disease (AD). This study evaluated efficacy, safety, and tolerability of a higher-dose, once-daily, extended-release formulation patients with AD concurrently taking cholinesterase inhibitors. In this 24-week, double-blind, multinational (NCT00322153), outpatients (Mini-Mental State Examination scores 3–14) were randomized to receive 28-mg, or placebo. Co-primary efficacy parameters...
<h3>Objective:</h3> To report safety and efficacy outcomes from up to 9 years of treatment with teriflunomide in an extension (NCT00803049) the pivotal phase 3 Teriflunomide Multiple Sclerosis Oral (TEMSO) trial (NCT00134563). <h3>Methods:</h3> A total 742 patients entered extension. Teriflunomide-treated continued original dose; those previously receiving placebo were randomized 1:1 14 mg or 7 mg. <h3>Results:</h3> By June 2013, median (maximum) exposure exceeded 190 (325) weeks per...
Recurrent spontaneous panic attacks are psychophysiological symptoms present in disorder and agoraphobia with attacks. Effective pharmacological treatment for is essential to any plan these conditions. The authors administered chlomipramine 20 patients who had or attacks, after 8 weeks of 75% the each diagnosis were asymptomatic. These results support claim that highly effective preventing recurrence
Background: Population-attributable risk (PAR) may help estimate the potential contribution of adverse childhood experiences (ACEs) to serious clinical presentations depression, characterized by suicidality, previous psychiatric admissions, and episode recurrence. Objective: To determine PAR ACEs for depression (high suicide risk, recurrent depression) in outpatients with ICD-10 depression. Method: Systematic chart review 1,013 adults who were assessed and/or treated a mental health clinic...
Background: Caring for a person with dementia is associated well-documented increases in burden and distress decreases mental health wellbeing. Studies assessing caregivers of patients its determinants are
The purpose of this study is to improve the current understanding relation between depression and attachment through evaluation role personality styles (dependent vs self-critical) social support in association. These variables were studied a clinical sample 70 depressed outpatients (83% women; M=41.47 years, SD=12.91). Depressive symptomatology was assessed Beck Depression Inventory, adult Experiences Close Relationships Scale, Social Support Questionnaire dependency self-criticism...
Major depression is a highly prevalent and severe mental disease. Despite the effective treatment options available, risk of relapse high. Interventions based on information communication technologies generate innovative opportunities to provide support patients after they completed for depression.This acceptability study evaluated Internet-based program Apoyo, Seguimiento y Cuidado de Enfermedades partir Sistemas Operativos (ASCENSO) in terms its feasibility sample 35 Chile.The reveals high...
In the psychiatric literature, panic attacks have been considered as part of clinical manifestations anxiety neurosis, agoraphobia, functional cardiovascular disturbances, and phobic depersonalization syndrome. Even though recurrent spontaneous are described in these entities, importance ascribed to them has minor one. Therefore, poorly understood from a psycho-physio pathological point view. past years, new trends nosology disorders grouped under heading "panic disorder agoraphobia with...
Childhood Trauma Questionnaire-Short Form (CTQ-SF) is an instrument to assess child abuse and neglect Aim: adapt confirm the psychometric properties of Spanish version CTQ-SF in Chile.The was applied 89 clinically depressed subjects (77.5% women) who consulted at outpatient mental health clinic. Confirmatory factor analysis (CFA), reliability (Cronbach's α) tests, convergent validity analyses with clinical markers complex depression were carried out.The Chilean demonstrated acceptable fit a...
Clinically-evaluated nutraceuticals are candidates for Alzheimer's disease (AD) prevention and treatment. Phase I studies showed biological safety of the nutraceutical BrainUp-10®, while a pilot trial demonstrated efficacy Cell neuroprotection. BrainUp-10® blocks tau self-assembly. Apathy is most common behavioral alterations.The aim was to explore in mitigating cognitive symptoms providing life quality, cohort Chilean patients with mild moderate AD.The multicenter, randomized, double blind,...
Internet-based interventions promise to enhance the accessibility of mental health care for a greater number people and in more remote places. Their effectiveness has been shown prevention treatment various disorders. However, their potential when delivered as add-on conventional (ie, blended care) is less clear.The aim this study an internet intervention (ASCENSO) implemented addition face-to-face usual (TAU) depression.A 2-arm, parallel-group, randomized controlled trial was conducted...
Seventeen outpatients with panic anxiety and agoraphobia were treated a low, flexible dose of clomipramine in an 8-week open trial. Panic attacks ceased completely 13 patients markedly decreased the other four without additional therapeutic measures. Avoidance behavior disappeared five seven agoraphobic patients. Overall mean dosage was 45 mg/day, eight receiving 25 mg or less. Higher doses needed when present. These results are discussed conjunction previous findings lend support to...
This study describes the psychometric properties of a Spanish version Shortened Outcome Questionnaire (OQ-30.2, Lambert et al., 2004), made for Chilean population. The questionnaire was administered to 546 patients in an outpatient mental health clinic and 100 non-clinical adults. Results indicated that measure has good internal consistency (α=0.90) sensitivity change. Furthermore, results were similar those obtained its original version, making possible use context.
ResumenEsta investigación tiene por objetivo estudiar los Indicadores de Cambio Genéricos (ICG) en psicoterapias con adolescentes, realizadas contexto natural.Específicamente focaliza la evolución ICG al interior etapa inicial terapia y su relación adherencia tratamiento.Participaron 19 diferentes diagnósticos, modalidad individual orientaciones teóricas.Evaluadores entrenados identificaron las tres sesiones iniciales.Los resultados indican que se observa una terapia, el sentido un...
La presente investigacion tuvo por objetivo estandarizar el cuestionario Parental Bonding Instrument, P.B.I (2), a la poblacion de entre 16 y 64 anos eda d del Gran Santiago. Este instrumento medicion psicologica esta basado en Teoria Vinculo mide percepcion sujeto sobre las conductas actitudes sus cuidadores, para conocer contribucion parental apego establecer tipo vinculo sujeto. Se aplico una muestra 542 personas, controlando variables sexo, edad nivel socioeconomico (N.S.E.). realizo un...
We report on a 39-year-old woman suffering from deep venous thrombosis due to heterozygous factor-V-Leiden mutation with resistance activated protein C. Four months after beginning oral anticoagulation, generalized jaundice appeared. Subsequently, subacute liver failure developed necessitating an orthotopic transplantation. Histopathology showed features of extensive cell necrosis without evidence substantial inflammatory infiltrate. Based histopathology and exclusion other diseases,...